hasProteinBinding
P37224
predicate
Indicates that one entity is capable of physically binding to or interacting specifically with a protein.
All labels observed (10)
| Label | Occurrences |
|---|---|
| hasProteinBinding canonical | 28 |
| proteinBinding | 9 |
| isHighlyProteinBound | 5 |
| affectsProtein | 4 |
| proteinIsoformBindsReceptor | 2 |
| proteinProductInteractsWith | 2 |
| hasEpitope | 1 |
| hasProteinBinding_percent | 1 |
| highlyProteinBound | 1 |
| isProteinBound | 1 |
Description generation (PDg)
The one-sentence description above was generated by prompting gpt-5.1 with the predicate name and this instruction.
Instruction
Given a predicate that represents a relationship or action between entities, generate a one-sentence description explaining its meaning. # Instructions Focus on describing the relationship, not the entities themselves. # Response Format Begin the description with \' Indicates...\'
Input
Predicate: hasProteinBinding
Generated description
Indicates that one entity is capable of physically binding to or interacting specifically with a protein.
Sample triples (54)
| Subject | Object |
|---|---|
| Xarelto | high plasma protein binding ⓘ |
| zanamivir | low protein binding ⓘ |
| rivastigmine | about 40 percent ⓘ |
|
Memantine
linked to:
memantine
|
low ⓘ |
| Donepezil | high via predicate surface "proteinBinding" ⓘ |
| risdiplam |
SMN protein
via predicate surface "affectsProtein"
ⓘ
linked to:
survival motor neuron protein
|
|
Riluzole
linked to:
riluzole
|
about 96 percent ⓘ |
| methotrexate | about 50% ⓘ |
| warfarin | high via predicate surface "proteinBinding" ⓘ |
| apixaban | approximately 87 percent ⓘ |
| bortezomib | high via predicate surface "proteinBinding" ⓘ |
| dabigatran | approximately 35 percent ⓘ |
| Epidiolex | high via predicate surface "proteinBinding" ⓘ |
| Dravet syndrome | Nav1.1 sodium channel via predicate surface "affectsProtein" ⓘ |
| rimonabant | true via predicate surface "isHighlyProteinBound" ⓘ |
| cyclophosphamide | 20–50% ⓘ |
|
Docetaxel
linked to:
docetaxel
|
>94% via predicate surface "proteinBinding" ⓘ |
| Delta variant | Spike protein via predicate surface "affectsProtein" ⓘ |
| Lipitor | high via predicate surface "proteinBinding" ⓘ |
| Zoloft | 98 via predicate surface "hasProteinBinding_percent" ⓘ |
| APOE gene | LDL receptor via predicate surface "proteinProductInteractsWith" ⓘ |
| APOE gene |
LDL receptor–related protein 1
via predicate surface "proteinProductInteractsWith"
ⓘ
linked to:
LRP1
|
| APOE ε3 allele | LDL receptor via predicate surface "proteinIsoformBindsReceptor" ⓘ |
| APOE ε3 allele | LRP1 via predicate surface "proteinIsoformBindsReceptor" ⓘ |
|
Amphotericin B
linked to:
amphotericin B
|
>90% ⓘ |
| posaconazole | true via predicate surface "highlyProteinBound" ⓘ |
| Evrysdi | survival motor neuron protein via predicate surface "affectsProtein" ⓘ |
| fluconazole | low to moderate protein binding ⓘ |
| pimozide | true via predicate surface "isHighlyProteinBound" ⓘ |
| thioridazine | high protein binding ⓘ |
| bapineuzumab | N-terminus of amyloid beta via predicate surface "hasEpitope" ⓘ |
| dihydroartemisinin | moderate protein binding ⓘ |
|
Benserazide
linked to:
benserazide
|
low ⓘ |
| entacapone | high protein binding ⓘ |
| carbidopa | about 36% via predicate surface "proteinBinding" ⓘ |
| phenytoin | >90% ⓘ |
| probenecid | high protein binding via predicate surface "isProteinBound" ⓘ |
| ketoconazole | true via predicate surface "isHighlyProteinBound" ⓘ |
| itraconazole | true via predicate surface "isHighlyProteinBound" ⓘ |
| clarithromycin | about 70% ⓘ |
| carbamazepine | 70–80% ⓘ |
|
Terfenadine
linked to:
terfenadine
|
high ⓘ |
|
Cyclosporine A
linked to:
cyclosporine A
|
>90% ⓘ |
| sulfasalazine | 99% ⓘ |
| pomalidomide | 12–44% ⓘ |
| valproate | high ⓘ |
| topiramate | 13–17% ⓘ |
| lamotrigine | approximately 55 percent ⓘ |
| acalabrutinib | high via predicate surface "proteinBinding" ⓘ |
| zanubrutinib | high via predicate surface "proteinBinding" ⓘ |