amphotericin B
E556051
Amphotericin B is a broad-spectrum antifungal medication primarily used to treat severe, systemic fungal infections.
All labels observed (1)
| Label | Occurrences |
|---|---|
| amphotericin B canonical | 4 |
How this entity was disambiguated
This entity first appeared as the object of triple T5931325 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: amphotericin B Context triple: [Sporothrix, alternativeTreatment, amphotericin B]
-
A.
rifampicin
Rifampicin is a broad-spectrum rifamycin antibiotic widely used as a first-line drug in the treatment of tuberculosis and other serious bacterial infections.
-
B.
Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
-
C.
Balemartine
Balemartine is a small coastal village located on the island of Tiree in Scotland’s Inner Hebrides.
-
D.
amantadine
Amantadine is an antiviral and antiparkinsonian medication used to help manage motor symptoms such as tremor and rigidity in people with Parkinson’s disease.
-
E.
Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: amphotericin B Target entity description: Amphotericin B is a broad-spectrum antifungal medication primarily used to treat severe, systemic fungal infections.
-
A.
rifampicin
Rifampicin is a broad-spectrum rifamycin antibiotic widely used as a first-line drug in the treatment of tuberculosis and other serious bacterial infections.
-
B.
Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
-
C.
Balemartine
Balemartine is a small coastal village located on the island of Tiree in Scotland’s Inner Hebrides.
-
D.
amantadine
Amantadine is an antiviral and antiparkinsonian medication used to help manage motor symptoms such as tremor and rigidity in people with Parkinson’s disease.
-
E.
Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
antifungal agent
ⓘ
medication ⓘ polyene antifungal drug ⓘ |
| canBeCombinedWith | flucytosine ⓘ |
| combinedWithFlucytosineUsedFor | induction therapy of cryptococcal meningitis ⓘ |
| derivedFrom |
Streptomyces nodosus
ⓘ
linked to:
Streptomyces
|
| discoveredBy | Squibb Institute for Medical Research ⓘ |
| hasAdverseEffect |
anemia
ⓘ
fever and chills ⓘ hypokalemia ⓘ infusion-related reactions ⓘ nephrotoxicity ⓘ |
| hasATCCode | J02AA01 ⓘ |
| hasBioavailability | very low oral bioavailability ⓘ |
| hasBlackBoxWarning | should be used primarily for progressive, potentially life-threatening fungal infections ⓘ |
| hasCASNumber | 1397-89-3 ⓘ |
| hasChemicalFormula | C47H73NO17 ⓘ |
| hasEffect |
causes leakage of intracellular contents of fungi
ⓘ
fungicidal or fungistatic depending on concentration and organism ⓘ |
| hasMechanismOfAction |
binds to ergosterol in fungal cell membranes
ⓘ
forms pores in fungal cell membranes ⓘ |
| hasMolarMass | 924.08 g/mol ⓘ |
| hasProteinBinding | >90% ⓘ |
| hasRouteOfAdministration |
intrathecal
ⓘ
intravenous ⓘ oral ⓘ topical ⓘ |
| hasSpectrumIncludes |
Aspergillus species
ⓘ
Blastomyces dermatitidis ⓘ Candida species ⓘ
linked to:
Candida albicans
Coccidioides species ⓘ Cryptococcus neoformans ⓘ Histoplasma capsulatum ⓘ Mucorales ⓘ |
| isAdministeredFor | severe systemic mycoses ⓘ |
| isBroadSpectrumAgainst | fungi ⓘ |
| isFormulatedAs |
colloidal dispersion amphotericin B
ⓘ
conventional deoxycholate formulation ⓘ lipid complex amphotericin B ⓘ liposomal amphotericin B ⓘ |
| isListedOn | World Health Organization Model List of Essential Medicines ⓘ |
| isNotAbsorbedFrom | gastrointestinal tract when given orally ⓘ |
| isOftenUsedAs | initial induction therapy for serious fungal infections ⓘ |
| liposomalFormulationsHaveProperty | reduced nephrotoxicity compared with conventional formulation ⓘ |
| usedForTreatmentOf |
aspergillosis
ⓘ
cryptococcal meningitis ⓘ invasive candidiasis ⓘ mucormycosis ⓘ systemic fungal infections ⓘ visceral leishmaniasis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: amphotericin B Description of subject: Amphotericin B is a broad-spectrum antifungal medication primarily used to treat severe, systemic fungal infections.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.