warfarin
E241385
Warfarin is a long-established oral anticoagulant used to prevent and treat blood clots, requiring regular blood monitoring and dose adjustments due to its narrow therapeutic range and numerous drug and food interactions.
All labels observed (2)
| Label | Occurrences |
|---|---|
| warfarin canonical | 10 |
| phenprocoumon | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2190690 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: warfarin Context triple: [Xarelto, isComparedWith, warfarin]
-
A.
Xarelto
Xarelto is a widely used prescription anticoagulant (blood thinner) that helps prevent and treat blood clots and reduce the risk of stroke in certain patients.
-
B.
Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
-
C.
Waylivra
Waylivra is a prescription antisense oligonucleotide therapy used to treat familial chylomicronemia syndrome (FCS) by reducing triglyceride levels in the blood.
-
D.
Versonnex
Versonnex is a small commune in the Ain department of eastern France, located near the Swiss border in the Pays de Gex region.
-
E.
Darzalex
Darzalex is a monoclonal antibody drug (daratumumab) used primarily in the treatment of multiple myeloma.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: warfarin Target entity description: Warfarin is a long-established oral anticoagulant used to prevent and treat blood clots, requiring regular blood monitoring and dose adjustments due to its narrow therapeutic range and numerous drug and food interactions.
-
A.
Xarelto
Xarelto is a widely used prescription anticoagulant (blood thinner) that helps prevent and treat blood clots and reduce the risk of stroke in certain patients.
-
B.
Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
-
C.
Waylivra
Waylivra is a prescription antisense oligonucleotide therapy used to treat familial chylomicronemia syndrome (FCS) by reducing triglyceride levels in the blood.
-
D.
Versonnex
Versonnex is a small commune in the Ain department of eastern France, located near the Swiss border in the Pays de Gex region.
-
E.
Darzalex
Darzalex is a monoclonal antibody drug (daratumumab) used primarily in the treatment of multiple myeloma.
- F. None of above. chosen
Statements (63)
| Predicate | Object |
|---|---|
| instanceOf |
anticoagulant drug
ⓘ
coumarin derivative ⓘ small molecule ⓘ vitamin K antagonist ⓘ |
| affects | coagulation cascade ⓘ |
| antidote |
fresh frozen plasma
ⓘ
prothrombin complex concentrate ⓘ vitamin K (phytonadione) ⓘ |
| approvedForMedicalUse | 1950s ⓘ |
| belongsToClass | vitamin K antagonists (VKAs) ⓘ |
| comparedWith | direct oral anticoagulants (DOACs) ⓘ |
| contraindicatedIn | pregnancy ⓘ |
| decreasesSynthesisOf |
coagulation factor II (prothrombin)
ⓘ
coagulation factor IX ⓘ coagulation factor VII ⓘ coagulation factor X ⓘ protein C ⓘ protein S ⓘ |
| discoveredIn | 1940s ⓘ |
| eliminationRoute | hepatic metabolism ⓘ |
| hasAdverseEffect |
gastrointestinal bleeding
ⓘ
intracranial hemorrhage ⓘ teratogenicity ⓘ warfarin-induced skin necrosis ⓘ |
| hasBlackBoxWarning | risk of major or fatal bleeding ⓘ |
| hasChemicalFormula | C19H16O4 ⓘ |
| hasEnantiomer |
R-warfarin
ⓘ
S-warfarin ⓘ |
| hasGenericName | warfarin ⓘ |
| hasHalfLife | approximately 20–60 hours ⓘ |
| hasHigherINRTargetRange | 2.5–3.5 for some mechanical valves ⓘ |
| hasIUPACName | 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one ⓘ |
| hasMajorAdverseEffect | bleeding ⓘ |
| hasMechanismOfAction |
inhibits vitamin K epoxide reductase complex 1 (VKORC1)
ⓘ
reduces synthesis of vitamin K–dependent clotting factors ⓘ |
| hasNarrowTherapeuticIndex | true ⓘ |
| hasPharmacogenomicAssociation |
CYP2C9 polymorphisms
ⓘ
VKORC1 polymorphisms ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
oral ⓘ |
| hasTypicalINRTargetRange | 2.0–3.0 ⓘ |
| interactsWith |
foods rich in vitamin K
ⓘ
herbal supplements ⓘ many over-the-counter drugs ⓘ many prescription drugs ⓘ |
| listedOn | World Health Organization Model List of Essential Medicines ⓘ |
| metabolizedBy |
CYP1A2
ⓘ
CYP2C9 ⓘ CYP3A4 ⓘ |
| originalUse | rodenticide ⓘ |
| proteinBinding | high ⓘ |
| requiresMonitoringOf |
international normalized ratio (INR)
ⓘ
prothrombin time (PT) ⓘ |
| requiresRegularDoseAdjustment | true ⓘ |
| S-warfarinMorePotentThanR-warfarin | true ⓘ |
| targets | VKORC1 ⓘ |
| usedFor |
prevention of stroke in atrial fibrillation
ⓘ
prevention of systemic embolism ⓘ prevention of thromboembolism in mechanical heart valves ⓘ prevention of venous thromboembolism ⓘ treatment of deep vein thrombosis ⓘ treatment of pulmonary embolism ⓘ treatment of venous thromboembolism ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: warfarin Description of subject: Warfarin is a long-established oral anticoagulant used to prevent and treat blood clots, requiring regular blood monitoring and dose adjustments due to its narrow therapeutic range and numerous drug and food interactions.
Referenced by (11)
Full triples — surface form annotated when it differs from this entity's canonical label.