CYP1A2
E561029
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
All labels observed (1)
| Label | Occurrences |
|---|---|
| CYP1A2 canonical | 9 |
How this entity was disambiguated
This entity first appeared as the object of triple T6003459 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CYP1A2 Context triple: [Cymbalta, isMetabolizedBy, CYP1A2]
-
A.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
-
B.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
C.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
D.
P-glycoprotein
P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
-
E.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CYP1A2 Target entity description: CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
A.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
-
B.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
C.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
D.
P-glycoprotein
P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
-
E.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
cytochrome P450 enzyme
ⓘ
drug-metabolizing enzyme ⓘ protein ⓘ |
| affects |
clearance of caffeine
ⓘ
clearance of clozapine ⓘ clearance of theophylline ⓘ |
| biologicalProcess |
drug metabolism
ⓘ
oxidation-reduction process ⓘ xenobiotic metabolic process ⓘ |
| chromosomalLocation | 15q24.1 ⓘ |
| encodes | cytochrome P450 1A2 protein ⓘ |
| expressedIn | liver ⓘ |
| gene | CYP1A2 ⓘ |
| hasMolecularFunction |
monooxygenase activity
ⓘ
oxidoreductase activity ⓘ |
| inducedBy |
cruciferous vegetables
ⓘ
omeprazole ⓘ polycyclic aromatic hydrocarbons ⓘ smoking ⓘ |
| inhibitedBy |
cimetidine
ⓘ
ciprofloxacin ⓘ enoxacin ⓘ fluoroquinolone antibiotics ⓘ fluvoxamine ⓘ oral contraceptives ⓘ |
| locatedIn | endoplasmic reticulum membrane ⓘ |
| memberOf |
CYP1 family
ⓘ
CYP1A subfamily ⓘ
linked to:
CYP1 family
cytochrome P450 superfamily ⓘ |
| organism | Homo sapiens ⓘ |
| polymorphismAssociatedWith |
risk of adverse drug reactions
ⓘ
variation in caffeine metabolism ⓘ variation in drug response ⓘ |
| regulatedBy | aryl hydrocarbon receptor ⓘ |
| substrateOf |
aflatoxin B1
ⓘ
amitriptyline ⓘ caffeine ⓘ clozapine ⓘ duloxetine ⓘ imipramine ⓘ olanzapine ⓘ phenacetin ⓘ polycyclic aromatic hydrocarbons ⓘ rasagiline ⓘ tacrine ⓘ theophylline ⓘ tizanidine ⓘ warfarin ⓘ |
| usesCofactor |
NADPH
ⓘ
heme ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CYP1A2 Description of subject: CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
Referenced by (9)
Full triples — surface form annotated when it differs from this entity's canonical label.