isSubstrateOf
P37222
predicate
Indicates that one entity serves as the material or reactant upon which another entity (typically an enzyme or process) acts in a chemical or biochemical reaction.
All labels observed (7)
| Label | Occurrences |
|---|---|
| substrateOf | 41 |
| isSubstrateOf canonical | 21 |
| substrateOfType | 5 |
| substrateRequirement | 3 |
| substrateMaterial | 2 |
| substrateClass | 1 |
| usedSubstrate | 1 |
Description generation (PDg)
The one-sentence description above was generated by prompting gpt-5.1 with the predicate name and this instruction.
Instruction
Given a predicate that represents a relationship or action between entities, generate a one-sentence description explaining its meaning. # Instructions Focus on describing the relationship, not the entities themselves. # Response Format Begin the description with \' Indicates...\'
Input
Predicate: isSubstrateOf
Generated description
Indicates that one entity serves as the material or reactant upon which another entity (typically an enzyme or process) acts in a chemical or biochemical reaction.
Sample triples (74)
| Subject | Object |
|---|---|
| Xarelto | P-glycoprotein ⓘ |
| Xarelto | BCRP ⓘ |
| Molecular computation of solutions to combinatorial problems | DNA via predicate surface "usedSubstrate" ⓘ |
| P-glycoprotein | many chemotherapeutic agents via predicate surface "substrateOfType" ⓘ |
| P-glycoprotein | cardiac glycosides such as digoxin via predicate surface "substrateOfType" ⓘ |
| P-glycoprotein | HIV protease inhibitors via predicate surface "substrateOfType" ⓘ |
| P-glycoprotein | immunosuppressants such as cyclosporine via predicate surface "substrateOfType" ⓘ |
| P-glycoprotein | various antibiotics via predicate surface "substrateOfType" ⓘ |
| BCRP | topotecan via predicate surface "substrateOf" ⓘ |
| BCRP | mitoxantrone via predicate surface "substrateOf" ⓘ |
| BCRP | methotrexate via predicate surface "substrateOf" ⓘ |
| BCRP | irinotecan and its metabolites via predicate surface "substrateOf" ⓘ |
| BCRP | imatinib via predicate surface "substrateOf" ⓘ |
| BCRP | rosuvastatin via predicate surface "substrateOf" ⓘ |
| BCRP | sulfasalazine via predicate surface "substrateOf" ⓘ |
| BCRP | fluoroquinolone antibiotics via predicate surface "substrateOf" ⓘ |
| BCRP | estrone-3-sulfate via predicate surface "substrateOf" ⓘ |
| BCRP | uric acid via predicate surface "substrateOf" ⓘ |
| apixaban | P-glycoprotein via predicate surface "substrateOf" ⓘ |
| apixaban |
breast cancer resistance protein
via predicate surface "substrateOf"
ⓘ
linked to:
BCRP
|
| dabigatran | P-glycoprotein ⓘ |
| NAD+ | dehydrogenases ⓘ |
| NAD+ | lactate dehydrogenase ⓘ |
| NAD+ | malate dehydrogenase ⓘ |
| NAD+ | glyceraldehyde-3-phosphate dehydrogenase ⓘ |
| NAD+ | isocitrate dehydrogenase (NAD+-dependent) ⓘ |
| NAD+ | sirtuins ⓘ |
| NAD+ | PARP enzymes ⓘ |
| NAD+ | CD38 ⓘ |
| NAD+ | ADP-ribosyltransferases ⓘ |
| Eschenmoser–Tanabe fragmentation | α,β-epoxy carbonyl system via predicate surface "substrateRequirement" ⓘ |
| vincristine | P-glycoprotein via predicate surface "substrateOf" ⓘ |
| Corey–Winter olefin synthesis | neighboring hydroxyl groups via predicate surface "substrateRequirement" ⓘ |
| Corey–Winter olefin synthesis | vicinal diol configuration via predicate surface "substrateRequirement" ⓘ |
| Tagrisso | CYP3A4 ⓘ |
| Tagrisso | CYP3A5 ⓘ |
| CYP1A2 | caffeine via predicate surface "substrateOf" ⓘ |
| CYP1A2 | theophylline via predicate surface "substrateOf" ⓘ |
| CYP1A2 | clozapine via predicate surface "substrateOf" ⓘ |
| CYP1A2 | olanzapine via predicate surface "substrateOf" ⓘ |
| CYP1A2 | tizanidine via predicate surface "substrateOf" ⓘ |
| CYP1A2 | duloxetine via predicate surface "substrateOf" ⓘ |
| CYP1A2 | rasagiline via predicate surface "substrateOf" ⓘ |
| CYP1A2 | tacrine via predicate surface "substrateOf" ⓘ |
| CYP1A2 | imipramine via predicate surface "substrateOf" ⓘ |
| CYP1A2 | amitriptyline via predicate surface "substrateOf" ⓘ |
| CYP1A2 | warfarin via predicate surface "substrateOf" ⓘ |
| CYP1A2 | phenacetin via predicate surface "substrateOf" ⓘ |
| CYP1A2 | aflatoxin B1 via predicate surface "substrateOf" ⓘ |
| CYP1A2 | polycyclic aromatic hydrocarbons via predicate surface "substrateOf" ⓘ |