rosuvastatin
E852341
Rosuvastatin is a statin medication used to lower cholesterol and reduce cardiovascular risk by inhibiting HMG-CoA reductase.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Crestor | 1 |
| rosuvastatin canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10291880 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: rosuvastatin Context triple: [BCRP, substrateOf, rosuvastatin]
-
A.
Lipitor
Lipitor is a widely prescribed statin medication used to lower cholesterol and reduce the risk of cardiovascular disease.
-
B.
Zetia
Zetia is a prescription cholesterol-lowering medication (generic name ezetimibe) that reduces intestinal absorption of cholesterol and is marketed by Merck & Co.
-
C.
Brilinta
Brilinta is a prescription antiplatelet medication (ticagrelor) used to reduce the risk of heart attack, stroke, and cardiovascular death in patients with acute coronary syndrome or a history of myocardial infarction.
-
D.
Entresto
Entresto is a prescription heart failure medication that combines sacubitril and valsartan to reduce the risk of cardiovascular death and hospitalization.
-
E.
Waylivra
Waylivra is a prescription antisense oligonucleotide therapy used to treat familial chylomicronemia syndrome (FCS) by reducing triglyceride levels in the blood.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: rosuvastatin Target entity description: Rosuvastatin is a statin medication used to lower cholesterol and reduce cardiovascular risk by inhibiting HMG-CoA reductase.
-
A.
Lipitor
Lipitor is a widely prescribed statin medication used to lower cholesterol and reduce the risk of cardiovascular disease.
-
B.
Zetia
Zetia is a prescription cholesterol-lowering medication (generic name ezetimibe) that reduces intestinal absorption of cholesterol and is marketed by Merck & Co.
-
C.
Brilinta
Brilinta is a prescription antiplatelet medication (ticagrelor) used to reduce the risk of heart attack, stroke, and cardiovascular death in patients with acute coronary syndrome or a history of myocardial infarction.
-
D.
Entresto
Entresto is a prescription heart failure medication that combines sacubitril and valsartan to reduce the risk of cardiovascular death and hospitalization.
-
E.
Waylivra
Waylivra is a prescription antisense oligonucleotide therapy used to treat familial chylomicronemia syndrome (FCS) by reducing triglyceride levels in the blood.
- F. None of above. chosen
Statements (57)
| Predicate | Object |
|---|---|
| instanceOf |
HMG-CoA reductase inhibitor
ⓘ
lipid-lowering drug ⓘ prescription drug ⓘ small molecule ⓘ statin ⓘ |
| approvedBy |
U.S. Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
| approvedIn | 2003 ⓘ |
| belongsToChemicalClass | pyrimidine-derived statin ⓘ |
| commonAdverseEffect |
abdominal pain
ⓘ
headache ⓘ myalgia ⓘ |
| contraindication |
active liver disease
ⓘ
breastfeeding ⓘ pregnancy ⓘ severe renal impairment without dose adjustment ⓘ |
| developedBy | AstraZeneca ⓘ |
| hasATCCode | C10AA07 ⓘ |
| hasBlackBoxWarning | fetal toxicity risk in pregnancy ⓘ |
| hasBrandName |
Crestor
ⓘ
linked to:
rosuvastatin
Rosulip ⓘ Rosuva ⓘ |
| hasCASNumber | 287714-41-4 ⓘ |
| hasChirality | contains chiral centers ⓘ |
| hasEliminationHalfLife | approximately 19 hours ⓘ |
| hasGenericName | rosuvastatin ⓘ |
| hasINN | rosuvastatin ⓘ |
| hasLegalStatus | prescription only ⓘ |
| hasMolecularFormula | C22H28FN3O6S ⓘ |
| hasPharmacologicalClass |
antihyperlipidemic agent
ⓘ
cardiovascular system agent ⓘ |
| hasPregnancyCategory | contraindicated ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| increasesBiomarker | high-density lipoprotein cholesterol ⓘ |
| isAdministeredAs | oral tablet ⓘ |
| isMetabolizedBy |
CYP2C19
ⓘ
CYP2C9 ⓘ |
| isSubstrateOf |
BCRP
ⓘ
OATP1B1 ⓘ
linked to:
SLCO1B1 (OATP1B1)
|
| isUsedInCombinationWith | ezetimibe ⓘ |
| maximumRecommendedDose | 40 mg once daily ⓘ |
| mechanismOfAction |
inhibition of HMG-CoA reductase
ⓘ
reduction of hepatic cholesterol synthesis ⓘ |
| reducesBiomarker |
low-density lipoprotein cholesterol
ⓘ
total cholesterol ⓘ triglycerides ⓘ |
| seriousAdverseEffect |
hepatic dysfunction
ⓘ
myopathy ⓘ rhabdomyolysis ⓘ |
| therapeuticUse |
increase of HDL cholesterol
ⓘ
prevention of cardiovascular events ⓘ reduction of LDL cholesterol ⓘ reduction of triglycerides ⓘ treatment of homozygous familial hypercholesterolemia ⓘ treatment of mixed dyslipidemia ⓘ treatment of primary hypercholesterolemia ⓘ |
| typicalStartingDose |
10 mg once daily
ⓘ
5 mg once daily ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: rosuvastatin Description of subject: Rosuvastatin is a statin medication used to lower cholesterol and reduce cardiovascular risk by inhibiting HMG-CoA reductase.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: rosuvastatin