hasContraindication
P23156
predicate
Indicates that one entity (such as a treatment, drug, or procedure) should not be used or performed in the presence of another entity (such as a condition, factor, or co-medication) because it may cause harm or adverse effects.
All labels observed (15)
| Label | Occurrences |
|---|---|
| contraindication | 127 |
| contraindicatedIn | 89 |
| hasContraindication canonical | 58 |
| isContraindicatedIn | 51 |
| contraindicatedWith | 35 |
| isContraindicatedWith | 12 |
| hasContraindicatedDrug | 4 |
| contraindicatedDrug | 3 |
| contraindicationNote | 2 |
| drugInteractionWarning | 2 |
| contraindicatedDrugClass | 1 |
| contraindicationCaution | 1 |
| contraindicationComponent | 1 |
| contraindicationContext | 1 |
| contraindications | 1 |
Description generation (PDg)
The one-sentence description above was generated by prompting gpt-5.1 with the predicate name and this instruction.
Instruction
Given a predicate that represents a relationship or action between entities, generate a one-sentence description explaining its meaning. # Instructions Focus on describing the relationship, not the entities themselves. # Response Format Begin the description with \' Indicates...\'
Input
Predicate: hasContraindication
Generated description
Indicates that one entity (such as a treatment, drug, or procedure) should not be used or performed in the presence of another entity (such as a condition, factor, or co-medication) because it may cause harm or adverse effects.
Sample triples (388)
| Subject | Object |
|---|---|
| Tecfidera | known hypersensitivity to dimethyl fumarate ⓘ |
| Plegridy | severe depression ⓘ |
| Plegridy | history of suicidal ideation ⓘ |
| Plegridy | severe hepatic impairment ⓘ |
| Tysabri | patients with a history of progressive multifocal leukoencephalopathy via predicate surface "contraindicatedIn" ⓘ |
| Tysabri | patients with severely compromised immune systems via predicate surface "contraindicatedIn" ⓘ |
| Vumerity | known hypersensitivity to diroximel fumarate via predicate surface "contraindicatedIn" ⓘ |
| Vumerity | known hypersensitivity to dimethyl fumarate via predicate surface "contraindicatedIn" ⓘ |
| Fampyra | history of seizures via predicate surface "contraindicatedIn" ⓘ |
| Fampyra | moderate or severe renal impairment via predicate surface "contraindicatedIn" ⓘ |
| Lucentis | ocular or periocular infection via predicate surface "contraindicatedIn" ⓘ |
| Lucentis | known hypersensitivity to ranibizumab via predicate surface "contraindicatedIn" ⓘ |
| Tylenol | alcohol increases risk of liver toxicity via predicate surface "drugInteractionWarning" ⓘ |
| Tylenol | other acetaminophen-containing products increase overdose risk via predicate surface "drugInteractionWarning" ⓘ |
| Remicade | severe heart failure via predicate surface "isContraindicatedIn" ⓘ |
| Remicade | patients with active serious infections via predicate surface "isContraindicatedIn" ⓘ |
| Xarelto | active pathological bleeding ⓘ |
| Xarelto | severe hypersensitivity to rivaroxaban ⓘ |
| Xarelto | significant hepatic disease associated with coagulopathy ⓘ |
| Darzalex | severe hypersensitivity to daratumumab via predicate surface "contraindication" ⓘ |
| Janssen COVID-19 Vaccine | severe allergic reaction to a previous dose via predicate surface "contraindication" ⓘ |
| Janssen COVID-19 Vaccine | known severe allergy to a component of the vaccine via predicate surface "contraindication" ⓘ |
| Imbruvica | strong CYP3A4 inhibitors via predicate surface "isContraindicatedWith" ⓘ |
| Avastin | recent major surgery via predicate surface "contraindication" ⓘ |
| Avastin | uncontrolled hypertension via predicate surface "contraindication" ⓘ |
| Herceptin | severe hypersensitivity to trastuzumab via predicate surface "isContraindicatedWith" ⓘ |
| Rituxan | known severe hypersensitivity to rituximab via predicate surface "contraindicatedIn" ⓘ |
| Activase | active internal bleeding via predicate surface "contraindicatedIn" ⓘ |
| Activase | history of recent intracranial hemorrhage via predicate surface "contraindicatedIn" ⓘ |
| Activase | suspected subarachnoid hemorrhage via predicate surface "contraindicatedIn" ⓘ |
| Perjeta | pregnancy via predicate surface "contraindication" ⓘ |
| Stelara | patients with clinically significant hypersensitivity to ustekinumab via predicate surface "isContraindicatedIn" ⓘ |
| oseltamivir | patients with known hypersensitivity to oseltamivir via predicate surface "contraindicatedIn" ⓘ |
| rVSV-ZEBOV | use in certain immunocompromised individuals may be restricted via predicate surface "contraindication" ⓘ |
| rVSV-ZEBOV | use in pregnancy may be restricted via predicate surface "contraindication" ⓘ |
| zanamivir | patients with severe milk protein allergy via predicate surface "contraindicatedIn" ⓘ |
| BCG vaccine | severe immunodeficiency via predicate surface "contraindication" ⓘ |
| BCG vaccine | symptomatic HIV infection in infants via predicate surface "contraindication" ⓘ |
| REGN-EB3 | not recommended for prophylactic use via predicate surface "contraindicationNote" ⓘ |
| rivastigmine | known hypersensitivity to rivastigmine ⓘ |
| rivastigmine | previous allergic dermatitis from rivastigmine patch ⓘ |
|
Memantine
linked to:
memantine
|
hypersensitivity to memantine via predicate surface "contraindication" ⓘ |
| Donepezil | hypersensitivity to donepezil via predicate surface "contraindication" ⓘ |
| Trulicity | patients with personal or family history of medullary thyroid carcinoma via predicate surface "isContraindicatedIn" ⓘ |
| Trulicity | patients with multiple endocrine neoplasia syndrome type 2 via predicate surface "isContraindicatedIn" ⓘ |
| Zepbound | personal or family history of medullary thyroid carcinoma via predicate surface "contraindication" ⓘ |
| Zepbound | multiple endocrine neoplasia syndrome type 2 via predicate surface "contraindication" ⓘ |
| Cymbalta | concomitant use with MAO inhibitors ⓘ |
| Cymbalta | uncontrolled narrow-angle glaucoma ⓘ |
| Alimta | severe renal impairment via predicate surface "isContraindicatedIn" ⓘ |