Plegridy
E24878
Plegridy is a pegylated interferon beta-1a medication used to treat relapsing forms of multiple sclerosis.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Plegridy canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T195374 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Plegridy Context triple: [Biogen, hasProduct, Plegridy]
-
A.
Philortyx
Philortyx is a genus of New World quails known for their ground-dwelling habits and occurrence in scrub and grassland habitats of the Americas.
-
B.
Golus
Golus is a Yiddish term referring to the Jewish exile and dispersion from their ancestral homeland, encompassing both the physical diaspora and its spiritual-historical implications.
-
C.
Gweru
Gweru is a central Zimbabwean city that serves as the capital of the Midlands Province and an important commercial and transportation hub.
-
D.
Bladon
Bladon is a village in Oxfordshire, England, best known as the burial place of Sir Winston Churchill.
-
E.
Pregny-Chambésy
Pregny-Chambésy is a small, affluent municipality on the shores of Lake Geneva in the canton of Geneva, Switzerland, known for hosting several international organizations and diplomatic missions.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Plegridy Target entity description: Plegridy is a pegylated interferon beta-1a medication used to treat relapsing forms of multiple sclerosis.
-
A.
Philortyx
Philortyx is a genus of New World quails known for their ground-dwelling habits and occurrence in scrub and grassland habitats of the Americas.
-
B.
Golus
Golus is a Yiddish term referring to the Jewish exile and dispersion from their ancestral homeland, encompassing both the physical diaspora and its spiritual-historical implications.
-
C.
Gweru
Gweru is a central Zimbabwean city that serves as the capital of the Midlands Province and an important commercial and transportation hub.
-
D.
Bladon
Bladon is a village in Oxfordshire, England, best known as the burial place of Sir Winston Churchill.
-
E.
Pregny-Chambésy
Pregny-Chambésy is a small, affluent municipality on the shores of Lake Geneva in the canton of Geneva, Switzerland, known for hosting several international organizations and diplomatic missions.
- F. None of above. chosen
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
disease-modifying therapy
ⓘ
medication ⓘ pegylated interferon beta-1a ⓘ |
| activeIngredient | peginterferon beta-1a ⓘ |
| belongsToClass |
immunomodulatory agents
ⓘ
interferon beta-1a ⓘ |
| hasAdministrationFrequency | every 14 days ⓘ |
| hasApprovalAuthority |
European Medicines Agency
ⓘ
U.S. Food and Drug Administration ⓘ
linked to:
Food and Drug Administration
|
| hasATCCode | L03AB13 ⓘ |
| hasBlackBoxWarning |
risk of depression and suicide
ⓘ
risk of hepatotoxicity ⓘ |
| hasCommonSideEffect |
chills
ⓘ
flu-like symptoms ⓘ headache ⓘ injection site reactions ⓘ myalgia ⓘ pyrexia ⓘ |
| hasContraindication |
history of suicidal ideation
ⓘ
severe depression ⓘ severe hepatic impairment ⓘ |
| hasDeveloper | Biogen ⓘ |
| hasDosageForm |
pre-filled pen
ⓘ
pre-filled syringe ⓘ solution for injection ⓘ |
| hasEffect |
reduces MRI lesion activity
ⓘ
reduces relapse rate in multiple sclerosis ⓘ slows disability progression ⓘ |
| hasLegalStatusEU | prescription only ⓘ |
| hasLegalStatusUS | prescription only ⓘ |
| hasManufacturer | Biogen ⓘ |
| hasMechanismOfAction |
immunomodulation
ⓘ
reduction of inflammatory responses in multiple sclerosis ⓘ |
| hasPregnancyCategoryUS | C ⓘ |
| hasRouteOfAdministration |
subcutaneous
ⓘ
subcutaneous injection ⓘ |
| hasSeriousSideEffect |
depression
ⓘ
hepatotoxicity ⓘ pulmonary arterial hypertension ⓘ suicidal ideation ⓘ thrombotic microangiopathy ⓘ |
| hasTradeName | Plegridy ⓘ |
| isAdministeredTo | adults ⓘ |
| isPegylated | true ⓘ |
| isUsedFor | long-term treatment of multiple sclerosis ⓘ |
| treats |
active secondary progressive multiple sclerosis
ⓘ
clinically isolated syndrome ⓘ relapsing forms of multiple sclerosis ⓘ relapsing-remitting multiple sclerosis ⓘ |
| wasApprovedInEU | 2014 ⓘ |
| wasApprovedInUS | 2014 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Plegridy Description of subject: Plegridy is a pegylated interferon beta-1a medication used to treat relapsing forms of multiple sclerosis.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.