Activase
E46090
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
All labels observed (2)
How this entity was disambiguated
This entity first appeared as the object of triple T363285 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Activase Context triple: [Genentech, notableProduct, Activase]
-
A.
Vumerity
Vumerity is an oral prescription medication used to treat relapsing forms of multiple sclerosis in adults.
-
B.
Plegridy
Plegridy is a pegylated interferon beta-1a medication used to treat relapsing forms of multiple sclerosis.
-
C.
Leqembi
Leqembi is an Alzheimer’s disease drug (lecanemab) that targets amyloid-beta plaques to slow cognitive decline in early-stage patients.
-
D.
Philortyx
Philortyx is a genus of New World quails known for their ground-dwelling habits and occurrence in scrub and grassland habitats of the Americas.
-
E.
Abital
Abital is one of the lesser-known wives of the biblical King David, mentioned in the Hebrew Bible as the mother of his son Shephatiah.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Activase Target entity description: Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
-
A.
Vumerity
Vumerity is an oral prescription medication used to treat relapsing forms of multiple sclerosis in adults.
-
B.
Plegridy
Plegridy is a pegylated interferon beta-1a medication used to treat relapsing forms of multiple sclerosis.
-
C.
Leqembi
Leqembi is an Alzheimer’s disease drug (lecanemab) that targets amyloid-beta plaques to slow cognitive decline in early-stage patients.
-
D.
Philortyx
Philortyx is a genus of New World quails known for their ground-dwelling habits and occurrence in scrub and grassland habitats of the Americas.
-
E.
Abital
Abital is one of the lesser-known wives of the biblical King David, mentioned in the Hebrew Bible as the mother of his son Shephatiah.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
brand-name drug
ⓘ
fibrinolytic drug ⓘ prescription medicine ⓘ thrombolytic agent ⓘ |
| affectsBiologicalProcess | fibrinolysis ⓘ |
| contraindicatedIn |
active internal bleeding
ⓘ
history of recent intracranial hemorrhage ⓘ suspected subarachnoid hemorrhage ⓘ |
| developedBy | Genentech ⓘ |
| hasActiveIngredient |
alteplase
ⓘ
linked to:
Activase
|
| hasATCCode | B01AD02 ⓘ |
| hasDosageForm | lyophilized powder for solution ⓘ |
| hasDrugClass |
fibrinolytic
ⓘ
thrombolytic ⓘ tissue plasminogen activator ⓘ |
| hasGenericName |
alteplase
ⓘ
linked to:
Activase
|
| hasManufacturer | Genentech ⓘ |
| hasPregnancyCategory | use only if potential benefit justifies potential risk ⓘ |
| hasRegulatoryStatus | prescription only ⓘ |
| hasTarget | plasminogen ⓘ |
| indicatedFor |
ST-elevation myocardial infarction
ⓘ
acute ischemic stroke ⓘ acute massive pulmonary embolism ⓘ acute myocardial infarction ⓘ pulmonary embolism ⓘ restoration of function to occluded central venous access devices ⓘ |
| isAdministeredBy | healthcare professional ⓘ |
| isApprovedBy |
U.S. Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
| isBrandOf |
alteplase
ⓘ
linked to:
Activase
|
| isGivenAs | intravenous bolus followed by infusion (indication-specific) ⓘ |
| isMarketedIn |
United States
ⓘ
linked to:
United States of America
|
| isReconstitutedWith | sterile water for injection ⓘ |
| isUsedAs |
clot-dissolving drug
ⓘ
thrombolytic treatment ⓘ |
| majorAdverseEffect |
intracranial hemorrhage
ⓘ
major bleeding ⓘ orolingual angioedema ⓘ |
| mechanismOfAction |
converts plasminogen to plasmin
ⓘ
promotes fibrin clot breakdown ⓘ |
| requiresImagingBeforeUse | brain imaging to exclude hemorrhage ⓘ |
| requiresMonitoringOf |
blood pressure
ⓘ
neurological status ⓘ signs of bleeding ⓘ |
| routeOfAdministration | intravenous ⓘ |
| timeWindowForAcuteIschemicStroke | within several hours of symptom onset ⓘ |
| treatsPathophysiologicProcess | thrombus formation ⓘ |
| usedWithinTimeWindowFor | acute ischemic stroke ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Activase Description of subject: Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Activase
linked to: Activase