Donepezil
E133125
Donepezil is a cholinesterase inhibitor medication primarily used to treat cognitive symptoms of Alzheimer's disease.
All labels observed (5)
| Label | Occurrences |
|---|---|
| Aricept | 3 |
| Donepezil canonical | 2 |
| Aricept ODT | 1 |
| Donepezil – Alzheimer’s disease | 1 |
| donepezil | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T1172267 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Donepezil Context triple: [Eisai, hasProduct, Donepezil]
-
A.
rivastigmine
Rivastigmine is a cholinesterase inhibitor medication used to manage symptoms of mild to moderate dementia, particularly in Alzheimer's and Parkinson's disease.
-
B.
memantine
Memantine is a medication that helps manage symptoms of moderate to severe Alzheimer's disease by modulating glutamate activity in the brain.
-
C.
Aduhelm
Aduhelm is an Alzheimer’s disease drug developed by Biogen that targets amyloid-beta plaques in the brain.
-
D.
Darzalex
Darzalex is a monoclonal antibody drug (daratumumab) used primarily in the treatment of multiple myeloma.
-
E.
Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Donepezil Target entity description: Donepezil is a cholinesterase inhibitor medication primarily used to treat cognitive symptoms of Alzheimer's disease.
-
A.
rivastigmine
Rivastigmine is a cholinesterase inhibitor medication used to manage symptoms of mild to moderate dementia, particularly in Alzheimer's and Parkinson's disease.
-
B.
memantine
Memantine is a medication that helps manage symptoms of moderate to severe Alzheimer's disease by modulating glutamate activity in the brain.
-
C.
Aduhelm
Aduhelm is an Alzheimer’s disease drug developed by Biogen that targets amyloid-beta plaques in the brain.
-
D.
Darzalex
Darzalex is a monoclonal antibody drug (daratumumab) used primarily in the treatment of multiple myeloma.
-
E.
Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
- F. None of above. chosen
Statements (62)
| Predicate | Object |
|---|---|
| instanceOf |
acetylcholinesterase inhibitor
ⓘ
cholinesterase inhibitor ⓘ medication ⓘ piperidine derivative ⓘ |
| approvedBy |
U.S. Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
| ATCCode | N06DA02 ⓘ |
| canBeUsedWith | memantine ⓘ |
| cautionIn |
patients with COPD
ⓘ
patients with asthma ⓘ patients with bradycardia ⓘ patients with cardiac conduction abnormalities ⓘ patients with peptic ulcer disease ⓘ |
| chemicalFormula | C24H29NO3 ⓘ |
| coMarketedBy | Pfizer ⓘ |
| commonSideEffect |
anorexia
ⓘ
diarrhea ⓘ fatigue ⓘ insomnia ⓘ muscle cramps ⓘ nausea ⓘ vomiting ⓘ |
| contraindication | hypersensitivity to donepezil ⓘ |
| crosses | blood–brain barrier ⓘ |
| developedBy | Eisai ⓘ |
| doesNotCure | Alzheimer's disease ⓘ |
| dosageForm |
oral tablet
ⓘ
orally disintegrating tablet ⓘ |
| effect | slows cognitive decline in Alzheimer's disease ⓘ |
| eliminationHalfLife | about 70 hours ⓘ |
| FDAApprovalYear | 1996 ⓘ |
| hasBrandName |
Aricept
ⓘ
linked to:
Donepezil
Aricept ODT ⓘ
linked to:
Donepezil
|
| hasGenericName | donepezil ⓘ |
| hasHigherDoseStrength | 23 mg once daily ⓘ |
| hasINN |
donepezil
ⓘ
linked to:
Donepezil
|
| hasMolecularWeight | 379.50 g/mol ⓘ |
| hasUSAN | donepezil ⓘ |
| increasesLevelOf | acetylcholine in the brain ⓘ |
| isListedOn | World Health Organization Model List of Essential Medicines ⓘ |
| isSelectiveFor | central nervous system acetylcholinesterase ⓘ |
| legalStatusEU | prescription only ⓘ |
| legalStatusUS | prescription only ⓘ |
| mechanismOfAction | reversible inhibition of acetylcholinesterase ⓘ |
| metabolizedBy |
CYP2D6
ⓘ
CYP3A4 ⓘ |
| pregnancyCategoryUS | C ⓘ |
| proteinBinding | high ⓘ |
| routeOfAdministration | oral ⓘ |
| seriousSideEffect |
bradycardia
ⓘ
gastrointestinal bleeding ⓘ seizures ⓘ syncope ⓘ |
| taken |
once daily
ⓘ
usually at bedtime ⓘ |
| treats |
Alzheimer's disease
ⓘ
mild Alzheimer's disease ⓘ moderate Alzheimer's disease ⓘ severe Alzheimer's disease ⓘ |
| typicalMaintenanceDose | 5–10 mg once daily ⓘ |
| typicalStartingDose | 5 mg once daily ⓘ |
| usedFor |
cognitive symptoms of Alzheimer's disease
ⓘ
dementia associated with Alzheimer's disease ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Donepezil Description of subject: Donepezil is a cholinesterase inhibitor medication primarily used to treat cognitive symptoms of Alzheimer's disease.
Referenced by (8)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Donepezil
linked to: Donepezil
linked to: Donepezil
linked to: Donepezil