CYP2D6
E559472
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
All labels observed (9)
How this entity was disambiguated
This entity first appeared as the object of triple T5981452 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CYP2D6 Context triple: [Donepezil, metabolizedBy, CYP2D6]
-
A.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
B.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
C.
P-glycoprotein
P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
-
D.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
E.
BCRP
BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CYP2D6 Target entity description: CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
-
A.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
B.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
C.
P-glycoprotein
P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
-
D.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
E.
BCRP
BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.
- F. None of above. chosen
Statements (64)
| Predicate | Object |
|---|---|
| instanceOf |
cytochrome P450 enzyme
ⓘ
drug-metabolizing enzyme ⓘ gene ⓘ |
| associatedWith |
adverse drug reactions to CYP2D6 substrates
ⓘ
breast cancer treatment outcome with tamoxifen ⓘ treatment failure with certain antidepressants ⓘ variable analgesic response to codeine ⓘ |
| belongsToFamily | cytochrome P450 family 2 ⓘ |
| belongsToSubfamily | cytochrome P450 subfamily D ⓘ |
| biologicalProcess |
drug metabolic process
ⓘ
oxidation-reduction process ⓘ xenobiotic metabolic process ⓘ |
| cellularComponent | endoplasmic reticulum membrane ⓘ |
| clinicalRelevance |
dose adjustment of CYP2D6 substrates
ⓘ
personalized medicine ⓘ pharmacogenomics ⓘ |
| cofactor |
NADPH
ⓘ
molecular oxygen ⓘ |
| encodes | cytochrome P450 2D6 protein ⓘ |
| enzymeCommissionNumber | EC 1.14.14.1 ⓘ |
| expressedIn |
brain
ⓘ
liver ⓘ small intestine ⓘ |
| fullName | cytochrome P450 family 2 subfamily D member 6 ⓘ |
| geneFamily |
CYP2D gene cluster
ⓘ
linked to:
CYP2D6
|
| hasAllele |
CYP2D6*1
ⓘ
linked to:
CYP2D6
CYP2D6*10 ⓘ
linked to:
CYP2D6
CYP2D6*17 ⓘ
linked to:
CYP2D6
CYP2D6*2 ⓘ CYP2D6*3 ⓘ
linked to:
CYP2D6
CYP2D6*4 ⓘ
linked to:
CYP2D6
CYP2D6*41 ⓘ
linked to:
CYP2D6
CYP2D6*5 ⓘ
linked to:
CYP2D6
|
| hasPhenotype |
extensive metabolizer
ⓘ
intermediate metabolizer ⓘ poor metabolizer ⓘ ultrarapid metabolizer ⓘ |
| highlyPolymorphic | true ⓘ |
| locatedIn | endoplasmic reticulum ⓘ |
| locatedOnChromosome | chromosome 22q13.2 ⓘ |
| metabolizes |
antiarrhythmics
ⓘ
antidepressants ⓘ antipsychotics ⓘ beta blockers ⓘ codeine ⓘ debrisoquine ⓘ dextromethorphan ⓘ metoprolol ⓘ opioid analgesics ⓘ tamoxifen ⓘ tramadol ⓘ |
| molecularFunction |
monooxygenase activity
ⓘ
oxidoreductase activity ⓘ |
| orthologIn |
Mus musculus
ⓘ
linked to:
house mouse (Mus musculus)
Rattus norvegicus ⓘ
linked to:
Norway rat (Rattus norvegicus)
|
| pathway |
drug metabolism via cytochrome P450
ⓘ
phase I xenobiotic metabolism ⓘ |
| polymorphismConsequence |
interindividual variability in drug response
ⓘ
variable drug clearance ⓘ variable drug efficacy ⓘ variable risk of adverse drug reactions ⓘ |
| species | Homo sapiens ⓘ |
| substrateType |
clinically used drugs
ⓘ
xenobiotics ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CYP2D6 Description of subject: CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
Referenced by (18)
Full triples — surface form annotated when it differs from this entity's canonical label.