quinidine
E852339
antiarrhythmic agent
class IA antiarrhythmic
pharmaceutical drug
quinoline alkaloid
stereoisomer of quinine
Quinidine is an antiarrhythmic medication derived from cinchona bark, primarily used to treat certain types of cardiac arrhythmias.
All labels observed (1)
| Label | Occurrences |
|---|---|
| quinidine canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T10291834 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: quinidine Context triple: [P-glycoprotein, inhibitorOfType, quinidine]
-
A.
Mectizan
Mectizan is the brand name for ivermectin, a medication widely used to prevent and treat river blindness (onchocerciasis) and certain other parasitic infections.
-
B.
Anacostine
Anacostine is an alternate name for the Nacotchtank, an Indigenous people who historically lived along the Anacostia River in what is now Washington, D.C.
-
C.
amantadine
Amantadine is an antiviral and antiparkinsonian medication used to help manage motor symptoms such as tremor and rigidity in people with Parkinson’s disease.
-
D.
Kotramide
Kotramide was a medieval Armenian noblewoman known primarily as the wife of King Ashot I Bagratuni, the first king of the Bagratid Kingdom of Armenia.
-
E.
Kalmit
Kalmit is a prominent mountain in southwestern Germany’s Palatinate region, known for its scenic views, hiking trails, and role as a popular local recreation area.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: quinidine Target entity description: Quinidine is an antiarrhythmic medication derived from cinchona bark, primarily used to treat certain types of cardiac arrhythmias.
-
A.
Mectizan
Mectizan is the brand name for ivermectin, a medication widely used to prevent and treat river blindness (onchocerciasis) and certain other parasitic infections.
-
B.
Anacostine
Anacostine is an alternate name for the Nacotchtank, an Indigenous people who historically lived along the Anacostia River in what is now Washington, D.C.
-
C.
amantadine
Amantadine is an antiviral and antiparkinsonian medication used to help manage motor symptoms such as tremor and rigidity in people with Parkinson’s disease.
-
D.
Kotramide
Kotramide was a medieval Armenian noblewoman known primarily as the wife of King Ashot I Bagratuni, the first king of the Bagratid Kingdom of Armenia.
-
E.
Kalmit
Kalmit is a prominent mountain in southwestern Germany’s Palatinate region, known for its scenic views, hiking trails, and role as a popular local recreation area.
- F. None of above. chosen
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf |
antiarrhythmic agent
ⓘ
class IA antiarrhythmic ⓘ pharmaceutical drug ⓘ quinoline alkaloid ⓘ stereoisomer of quinine ⓘ |
| belongsTo | World Health Organization list of essential medicines (historically for arrhythmias) ⓘ |
| bindsTo | cardiac sodium channels ⓘ |
| derivedFrom | cinchona bark ⓘ |
| discoveredFrom | Cinchona species ⓘ |
| excretedBy | kidney ⓘ |
| hasAdverseEffect |
QT prolongation
ⓘ
cinchonism ⓘ diarrhea ⓘ headache ⓘ hemolytic anemia ⓘ hypotension ⓘ nausea ⓘ thrombocytopenia ⓘ tinnitus ⓘ torsades de pointes ⓘ ventricular tachycardia ⓘ |
| hasATCCode | C01BA01 ⓘ |
| hasBioavailability | high oral bioavailability ⓘ |
| hasCASNumber | 56-54-2 ⓘ |
| hasChEBIID | CHEBI:8639 ⓘ |
| hasChemicalFormula | C20H24N2O2 ⓘ |
| hasContraindication |
complete heart block
ⓘ
history of torsades de pointes ⓘ myasthenia gravis ⓘ |
| hasDrugBankID | DB00908 ⓘ |
| hasHalfLife | approximately 6 to 8 hours ⓘ |
| hasIUPACName | (R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol ⓘ |
| hasMolarMass | 324.42 g/mol ⓘ |
| hasPharmacologicalEffect |
decreases myocardial excitability
ⓘ
slows conduction in the His-Purkinje system ⓘ |
| hasPregnancyCategory | varies by jurisdiction ⓘ |
| hasPubChemCID | 441074 ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
oral ⓘ |
| hasUNII | ITX08688JL ⓘ |
| inhibits |
CYP2D6
ⓘ
P-glycoprotein ⓘ |
| isOpticalIsomerOf | quinine ⓘ |
| mechanismOfAction |
blocks fast inward sodium current in cardiac tissue
ⓘ
prolongs QT interval ⓘ prolongs cardiac action potential duration ⓘ |
| metabolizedBy |
CYP2D6
ⓘ
CYP3A4 ⓘ |
| usedFor |
pharmacologic cardioversion of atrial fibrillation
ⓘ
treatment of atrial fibrillation ⓘ treatment of atrial flutter ⓘ treatment of supraventricular arrhythmias ⓘ treatment of ventricular arrhythmias ⓘ |
| usedWith | digoxin ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: quinidine Description of subject: Quinidine is an antiarrhythmic medication derived from cinchona bark, primarily used to treat certain types of cardiac arrhythmias.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.