P-glycoprotein
E241382
ABC transporter
ATP-dependent efflux transporter protein
drug transporter
membrane protein
multidrug resistance protein
xenobiotic transporter
P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
All labels observed (9)
| Label | Occurrences |
|---|---|
| P-glycoprotein canonical | 10 |
| ABCB1 | 3 |
| MDR1 | 2 |
| P-gp | 2 |
| ABCB1 (P-glycoprotein) | 1 |
| ABCB1 gene | 1 |
| MDR1 protein | 1 |
| P-glycoprotein (ABCB1) | 1 |
| multidrug resistance protein 1 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2190670 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: P-glycoprotein Context triple: [Xarelto, isSubstrateOf, P-glycoprotein]
-
A.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
B.
Plegridy
Plegridy is a pegylated interferon beta-1a medication used to treat relapsing forms of multiple sclerosis.
-
C.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
D.
programmed death-ligand 1
Programmed death-ligand 1 (PD-L1) is an immune checkpoint protein expressed on various cells that suppresses T-cell activity by engaging PD-1, enabling tumors to evade immune surveillance.
-
E.
Lipinski
Lipinski is a Polish-origin surname borne by various notable individuals in fields such as sports, music, and politics.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: P-glycoprotein Target entity description: P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
-
A.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
B.
Plegridy
Plegridy is a pegylated interferon beta-1a medication used to treat relapsing forms of multiple sclerosis.
-
C.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
D.
programmed death-ligand 1
Programmed death-ligand 1 (PD-L1) is an immune checkpoint protein expressed on various cells that suppresses T-cell activity by engaging PD-1, enabling tumors to evade immune surveillance.
-
E.
Lipinski
Lipinski is a Polish-origin surname borne by various notable individuals in fields such as sports, music, and politics.
- F. None of above. chosen
Statements (55)
| Predicate | Object |
|---|---|
| instanceOf |
ABC transporter
ⓘ
ATP-dependent efflux transporter protein ⓘ drug transporter ⓘ membrane protein ⓘ multidrug resistance protein ⓘ xenobiotic transporter ⓘ |
| affectsPharmacokineticsProcess |
brain penetration of drugs
ⓘ
drug absorption ⓘ drug distribution ⓘ drug elimination ⓘ oral bioavailability of drugs ⓘ |
| alsoKnownAs |
MDR1 protein
ⓘ
linked to:
P-glycoprotein
P-gp ⓘ
linked to:
P-glycoprotein
Pgp ⓘ multidrug resistance protein 1 ⓘ
linked to:
P-glycoprotein
|
| associatedWith |
drug–drug interactions
ⓘ
interindividual variability in drug response ⓘ multidrug resistance in cancer chemotherapy ⓘ reduced intracellular drug accumulation ⓘ |
| belongsToFamily | ATP-binding cassette transporter family ⓘ |
| belongsToSubfamily | ABC subfamily B ⓘ |
| biologicalProcess |
drug efflux
ⓘ
multidrug resistance ⓘ protection of tissues from xenobiotics ⓘ xenobiotic efflux ⓘ |
| cellularLocation |
apical membrane of epithelial cells
ⓘ
plasma membrane ⓘ |
| conservedIn | many mammalian species ⓘ |
| encodedBy |
ABCB1 gene
ⓘ
linked to:
P-glycoprotein
|
| foundInTissue |
blood–brain barrier endothelial cells
ⓘ
hematopoietic cells ⓘ intestinal epithelium ⓘ kidney proximal tubule epithelium ⓘ liver canalicular membrane ⓘ placental trophoblasts ⓘ |
| geneticVariationEffect | polymorphisms can alter expression or function ⓘ |
| hasMolecularFunction |
ATPase activity
ⓘ
drug efflux transporter activity ⓘ xenobiotic-transporting ATPase activity ⓘ |
| inhibitorOfType |
cyclosporine A
ⓘ
ketoconazole ⓘ quinidine ⓘ verapamil ⓘ |
| localRole |
limits drug entry into the central nervous system
ⓘ
limits fetal exposure to xenobiotics at the placenta ⓘ promotes biliary excretion of drugs ⓘ promotes renal tubular secretion of drugs ⓘ |
| organism | Homo sapiens ⓘ |
| substrateOfType |
HIV protease inhibitors
ⓘ
cardiac glycosides such as digoxin ⓘ immunosuppressants such as cyclosporine ⓘ many chemotherapeutic agents ⓘ various antibiotics ⓘ |
| transportMechanism | primary active transport ⓘ |
| usesEnergySource | ATP hydrolysis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: P-glycoprotein Description of subject: P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
Referenced by (22)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: P-glycoprotein
linked to: P-glycoprotein
linked to: P-glycoprotein
linked to: P-glycoprotein
subject linked to:
pregnane X receptor
linked to: P-glycoprotein
subject linked to:
pregnane X receptor
linked to: P-glycoprotein
linked to: P-glycoprotein
linked to: P-glycoprotein
linked to: P-glycoprotein
linked to: P-glycoprotein
linked to: P-glycoprotein
linked to: P-glycoprotein