Pgp
E852336
Pgp is a membrane transport protein that functions as an ATP-dependent efflux pump, playing a key role in multidrug resistance by exporting various drugs and xenobiotics out of cells.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Pgp canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T10291798 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Pgp Context triple: [P-glycoprotein, alsoKnownAs, Pgp]
-
A.
PGP
PGP (Pretty Good Privacy) is an encryption program that provides cryptographic privacy and authentication for data communication, most notably for securing emails and files.
-
B.
PGPL
PGPL is the top professional football league in Iran, featuring the country’s leading clubs in the highest tier of its league system.
-
C.
GNU Privacy Guard
GNU Privacy Guard is a free, open-source implementation of the OpenPGP standard used for encrypting and signing data and communications.
-
D.
PGPD
PGPD is the primary law enforcement agency responsible for policing and public safety in Prince George’s County, Maryland.
-
E.
gpgsm
gpgsm is the GNU Privacy Guard component that handles S/MIME public key cryptography, including X.509 certificate management and related operations.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Pgp Target entity description: Pgp is a membrane transport protein that functions as an ATP-dependent efflux pump, playing a key role in multidrug resistance by exporting various drugs and xenobiotics out of cells.
-
A.
PGP
PGP (Pretty Good Privacy) is an encryption program that provides cryptographic privacy and authentication for data communication, most notably for securing emails and files.
-
B.
PGPL
PGPL is the top professional football league in Iran, featuring the country’s leading clubs in the highest tier of its league system.
-
C.
GNU Privacy Guard
GNU Privacy Guard is a free, open-source implementation of the OpenPGP standard used for encrypting and signing data and communications.
-
D.
PGPD
PGPD is the primary law enforcement agency responsible for policing and public safety in Prince George’s County, Maryland.
-
E.
gpgsm
gpgsm is the GNU Privacy Guard component that handles S/MIME public key cryptography, including X.509 certificate management and related operations.
- F. None of above. chosen
Statements (57)
| Predicate | Object |
|---|---|
| instanceOf |
ABC transporter
ⓘ
ATP-dependent efflux pump ⓘ membrane transport protein ⓘ multidrug resistance protein ⓘ |
| affectsPharmacokineticsOf | many clinically used drugs ⓘ |
| alsoKnownAs |
ABCB1
ⓘ
linked to:
P-glycoprotein
MDR1 ⓘ
linked to:
P-glycoprotein
P-gp ⓘ
linked to:
P-glycoprotein
Pgp ⓘ |
| associatedWith |
chemotherapy failure in cancer
ⓘ
drug–drug interactions ⓘ |
| belongsToFamily | ATP-binding cassette transporter family ⓘ |
| confersResistanceTo |
antibiotics
ⓘ
anticancer drugs ⓘ antiviral drugs ⓘ cardiac glycosides ⓘ immunosuppressive drugs ⓘ |
| encodedByGene |
ABCB1
ⓘ
linked to:
P-glycoprotein
|
| foundInOrganism |
Homo sapiens
ⓘ
many mammalian species ⓘ |
| fullName | P-glycoprotein ⓘ |
| hasDomain |
two nucleotide-binding domains
ⓘ
two transmembrane domains ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
ATP-dependent xenobiotic efflux ⓘ ATPase activity coupled to transmembrane movement of substances ⓘ drug transmembrane transporter activity ⓘ |
| hasSubstrate |
HIV protease inhibitors
ⓘ
cyclosporine A ⓘ digoxin ⓘ doxorubicin ⓘ many hydrophobic xenobiotics ⓘ paclitaxel ⓘ vinblastine ⓘ vincristine ⓘ |
| inhibitedBy |
cyclosporine A
ⓘ
elacridar ⓘ tariquidar ⓘ verapamil ⓘ |
| locatedIn |
apical membrane of epithelial cells
ⓘ
blood–brain barrier endothelial cells ⓘ hematopoietic cells ⓘ intestinal epithelium ⓘ kidney proximal tubule epithelium ⓘ liver canalicular membrane ⓘ placental trophoblasts ⓘ plasma membrane ⓘ |
| participatesIn |
biliary excretion of drugs
ⓘ
blood–brain barrier function ⓘ drug efflux ⓘ limitation of oral drug absorption ⓘ multidrug resistance ⓘ protection of tissues from toxic xenobiotics ⓘ renal excretion of drugs ⓘ xenobiotic transport ⓘ |
| transportDirection | from intracellular space to extracellular space ⓘ |
| usesEnergySource | ATP hydrolysis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Pgp Description of subject: Pgp is a membrane transport protein that functions as an ATP-dependent efflux pump, playing a key role in multidrug resistance by exporting various drugs and xenobiotics out of cells.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.