thioridazine
E567199
Thioridazine is an older antipsychotic medication from the phenothiazine class, primarily used in the past to treat schizophrenia but now rarely prescribed due to its risk of serious heart rhythm disturbances.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Mellaril | 1 |
| thioridazine canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6064962 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: thioridazine Context triple: [Prozac, isContraindicatedWith, thioridazine]
-
A.
levodopa
Levodopa is a cornerstone medication for managing Parkinson’s disease symptoms by replenishing the brain’s depleted dopamine levels.
-
B.
Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
-
C.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
-
D.
rivastigmine
Rivastigmine is a cholinesterase inhibitor medication used to manage symptoms of mild to moderate dementia, particularly in Alzheimer's and Parkinson's disease.
-
E.
amantadine
Amantadine is an antiviral and antiparkinsonian medication used to help manage motor symptoms such as tremor and rigidity in people with Parkinson’s disease.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: thioridazine Target entity description: Thioridazine is an older antipsychotic medication from the phenothiazine class, primarily used in the past to treat schizophrenia but now rarely prescribed due to its risk of serious heart rhythm disturbances.
-
A.
levodopa
Levodopa is a cornerstone medication for managing Parkinson’s disease symptoms by replenishing the brain’s depleted dopamine levels.
-
B.
Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
-
C.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
-
D.
rivastigmine
Rivastigmine is a cholinesterase inhibitor medication used to manage symptoms of mild to moderate dementia, particularly in Alzheimer's and Parkinson's disease.
-
E.
amantadine
Amantadine is an antiviral and antiparkinsonian medication used to help manage motor symptoms such as tremor and rigidity in people with Parkinson’s disease.
- F. None of above. chosen
Statements (56)
| Predicate | Object |
|---|---|
| instanceOf |
antipsychotic medication
ⓘ
human drug ⓘ organic compound ⓘ phenothiazine derivative ⓘ typical antipsychotic ⓘ |
| actsOnReceptor |
alpha-1 adrenergic receptor
ⓘ
dopamine D1 receptor ⓘ dopamine D2 receptor ⓘ histamine H1 receptor ⓘ muscarinic acetylcholine receptor ⓘ |
| belongsToDrugClass |
dopamine receptor antagonist
ⓘ
phenothiazine antipsychotic ⓘ |
| hasActiveMetabolite |
mesoridazine
ⓘ
sulforidazine ⓘ |
| hasAdverseEffect |
anticholinergic effects
ⓘ
extrapyramidal symptoms ⓘ orthostatic hypotension ⓘ pigmentary retinopathy ⓘ retinal pigmentation (with high doses, long-term) ⓘ sedation ⓘ tardive dyskinesia ⓘ |
| hasATCCode | N05AC02 ⓘ |
| hasBioavailability | high oral bioavailability ⓘ |
| hasBlackBoxWarningFor | QT interval prolongation ⓘ |
| hasBrandName |
Mellaril
ⓘ
linked to:
thioridazine
Melleril ⓘ |
| hasCASNumber | 50-52-2 ⓘ |
| hasChEMBLID | CHEMBL841 ⓘ |
| hasChemicalFormula | C21H26N2S2 ⓘ |
| hasColor | white to off-white solid ⓘ |
| hasDosageForm |
oral solution
ⓘ
tablet ⓘ |
| hasDrugBankID | DB00679 ⓘ |
| hasHalfLife | approximately 6 to 40 hours (variable) ⓘ |
| hasIUPACName | 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine ⓘ |
| hasLegalStatus | prescription-only (where still available) ⓘ |
| hasMechanismOfAction |
blocks postsynaptic dopamine receptors in the mesolimbic system
ⓘ
exhibits anticholinergic and antihistaminic activity ⓘ |
| hasProteinBinding | high protein binding ⓘ |
| hasPubChemCID | 5452 ⓘ |
| hasRegulatoryStatus | withdrawn or severely restricted in many countries ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| hasSeriousAdverseEffect |
sudden cardiac death
ⓘ
torsades de pointes ⓘ ventricular arrhythmia ⓘ |
| hasTherapeuticUse |
treatment of psychotic disorders
ⓘ
treatment of schizophrenia ⓘ treatment of severe behavioral problems in children (historical) ⓘ |
| hasUNII | 1W32O8JAZA ⓘ |
| isContraindicatedIn |
patients with history of cardiac arrhythmias
ⓘ
patients with prolonged QT interval ⓘ |
| isContraindicatedWith | other QT-prolonging drugs ⓘ |
| isMetabolizedBy | CYP2D6 ⓘ |
| isNowRarelyUsedFor | first-line treatment of schizophrenia ⓘ |
| wasFirstApprovedIn | 1950s ⓘ |
| wasMarketedBy | Sandoz ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: thioridazine Description of subject: Thioridazine is an older antipsychotic medication from the phenothiazine class, primarily used in the past to treat schizophrenia but now rarely prescribed due to its risk of serious heart rhythm disturbances.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: thioridazine