H2 receptor antagonist cimetidine

E436638

H2 receptor antagonist anti-ulcer medication histamine H2 receptor blocker pharmaceutical drug

H2 receptor antagonist cimetidine is a pioneering anti-ulcer medication that reduces stomach acid production by blocking histamine H2 receptors in the gastric parietal cells.

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All labels observed (2)

Label	Occurrences
Tagamet	2
H2 receptor antagonist cimetidine canonical	1

How this entity was disambiguated

This entity first appeared as the object of triple T4394578 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: H2 receptor antagonist cimetidine
Context triple: [James Black, developed, H2 receptor antagonist cimetidine]

A. Pepcid
Pepcid is a widely used over-the-counter and prescription heartburn and acid reflux medication whose brand is owned by Kenvue.
B. Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
C. Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
D. Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
E. Lamotrek
Lamotrek is a small atoll in the Federated States of Micronesia known for its traditional seafaring culture and navigational expertise.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: H2 receptor antagonist cimetidine
Target entity description: H2 receptor antagonist cimetidine is a pioneering anti-ulcer medication that reduces stomach acid production by blocking histamine H2 receptors in the gastric parietal cells.

A. Pepcid
Pepcid is a widely used over-the-counter and prescription heartburn and acid reflux medication whose brand is owned by Kenvue.
B. Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
C. Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
D. Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
E. Lamotrek
Lamotrek is a small atoll in the Federated States of Micronesia known for its traditional seafaring culture and navigational expertise.
F. None of above. chosen

Statements (53)

Predicate	Object
instanceOf	H2 receptor antagonist ⓘ anti-ulcer medication ⓘ histamine H2 receptor blocker ⓘ pharmaceutical drug ⓘ
actsOn	gastric parietal cell ⓘ histamine H2 receptor ⓘ
belongsToGeneration	first-generation H2 blocker ⓘ
developedBy	Smith, Kline & French ⓘ
eliminatedPrimarilyBy	kidney ⓘ
hasAdverseEffect	confusion in elderly patients ⓘ diarrhea ⓘ elevated serum prolactin ⓘ gynecomastia ⓘ headache ⓘ impotence in males ⓘ rash ⓘ
hasATCCode	A02BA01 ⓘ
hasBioavailability	about 60–70 percent ⓘ
hasCASNumber	51481-61-9 ⓘ
hasDrugClass	H2 receptor antagonist ⓘ anti-secretory agent ⓘ gastric acid secretion inhibitor ⓘ
hasDrugInteractionEffect	increases plasma concentration of diazepam ⓘ increases plasma concentration of phenytoin ⓘ increases plasma concentration of theophylline ⓘ increases plasma concentration of warfarin ⓘ
hasEliminationHalfLife	about 2 hours in adults with normal renal function ⓘ
hasIUPACName	N-cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine ⓘ
hasMechanismOfAction	competitive antagonist at histamine H2 receptors ⓘ reduces gastric acid secretion by blocking H2 receptors on parietal cells ⓘ
hasMolecularFormula	C10H16N6S ⓘ
hasRouteOfAdministration	intramuscular ⓘ intravenous ⓘ oral ⓘ
hasTradeName	Tagamet ⓘ linked to: H2 receptor antagonist cimetidine
indicatedFor	Zollinger–Ellison syndrome ⓘ duodenal ulcer ⓘ gastric ulcer ⓘ gastroesophageal reflux disease ⓘ prevention of stress-related mucosal damage ⓘ
inhibits	CYP1A2 ⓘ CYP2C9 ⓘ CYP2D6 ⓘ CYP3A4 ⓘ cytochrome P450 enzymes ⓘ
reduces	acetylcholine-stimulated gastric acid secretion ⓘ basal gastric acid secretion ⓘ food-stimulated gastric acid secretion ⓘ gastrin-stimulated gastric acid secretion ⓘ histamine-stimulated gastric acid secretion ⓘ nocturnal gastric acid secretion ⓘ
wasFirstApprovedIn	1977 in the United States ⓘ
wasFirstInClass	first marketed H2 receptor antagonist ⓘ

How these facts were elicited

Referenced by (3)

Full triples — surface form annotated when it differs from this entity's canonical label.

James Black → developed → H2 receptor antagonist cimetidine ⓘ

SmithKline Beckman → notableProduct → Tagamet ⓘ

linked to: H2 receptor antagonist cimetidine

cimetidine → hasTradeName → Tagamet ⓘ

subject linked to: H2 receptor antagonist cimetidine