pimozide
E567198
diphenylbutylpiperidine derivative
dopamine receptor antagonist
small molecule
typical antipsychotic drug
Pimozide is a typical antipsychotic medication primarily used to treat Tourette’s disorder and severe tics.
All labels observed (1)
| Label | Occurrences |
|---|---|
| pimozide canonical | 3 |
How this entity was disambiguated
This entity first appeared as the object of triple T6064961 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: pimozide Context triple: [Prozac, isContraindicatedWith, pimozide]
-
A.
rivastigmine
Rivastigmine is a cholinesterase inhibitor medication used to manage symptoms of mild to moderate dementia, particularly in Alzheimer's and Parkinson's disease.
-
B.
levodopa
Levodopa is a cornerstone medication for managing Parkinson’s disease symptoms by replenishing the brain’s depleted dopamine levels.
-
C.
Namenda
Namenda is a prescription medication used to treat moderate to severe Alzheimer's disease by regulating the activity of glutamate in the brain.
-
D.
Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
-
E.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: pimozide Target entity description: Pimozide is a typical antipsychotic medication primarily used to treat Tourette’s disorder and severe tics.
-
A.
rivastigmine
Rivastigmine is a cholinesterase inhibitor medication used to manage symptoms of mild to moderate dementia, particularly in Alzheimer's and Parkinson's disease.
-
B.
levodopa
Levodopa is a cornerstone medication for managing Parkinson’s disease symptoms by replenishing the brain’s depleted dopamine levels.
-
C.
Namenda
Namenda is a prescription medication used to treat moderate to severe Alzheimer's disease by regulating the activity of glutamate in the brain.
-
D.
Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
-
E.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
diphenylbutylpiperidine derivative
ⓘ
dopamine receptor antagonist ⓘ small molecule ⓘ typical antipsychotic drug ⓘ |
| actsOn |
dopamine D2 receptor
ⓘ
dopamine D3 receptor ⓘ dopamine D4 receptor ⓘ |
| crossesBloodBrainBarrier | true ⓘ |
| hasAdverseEffect |
QT prolongation
ⓘ
akathisia ⓘ extrapyramidal symptoms ⓘ hyperprolactinemia ⓘ parkinsonism ⓘ sedation ⓘ tardive dyskinesia ⓘ torsades de pointes (rare) ⓘ weight gain ⓘ |
| hasATCCode | N05AG02 ⓘ |
| hasBlackBoxWarning |
risk of QT interval prolongation
ⓘ
risk of serious ventricular arrhythmias ⓘ |
| hasBrandName | Orap ⓘ |
| hasCASNumber | 2062-78-4 ⓘ |
| hasChemicalFormula | C28H29F2N3O ⓘ |
| hasContraindication |
concurrent use of CYP3A4 inhibitors that prolong QT interval
ⓘ
congenital long QT syndrome ⓘ history of cardiac arrhythmias ⓘ |
| hasEffect |
reduces frequency and severity of motor tics
ⓘ
reduces vocal tics ⓘ |
| hasHalfLife | approximately 55 to 66 hours ⓘ |
| hasIndication |
chronic psychotic disorders
ⓘ
delusional disorder (off-label in some regions) ⓘ schizophrenia (second-line) ⓘ |
| hasIUPACName | 1-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one ⓘ |
| hasLegalStatus | prescription only (in many countries) ⓘ |
| hasMechanismOfAction | blocks postsynaptic dopamine receptors in the brain ⓘ |
| hasMolarMass | 461.55 g/mol ⓘ |
| hasPharmacologicalClass |
antidopaminergic agent
ⓘ
neuroleptic ⓘ |
| hasPregnancyCategory | C (US, historical classification) ⓘ |
| hasPrimaryIndication |
Tourette syndrome
ⓘ
severe tics ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| isAvailableAs | oral tablet ⓘ |
| isHighlyProteinBound | true ⓘ |
| isMetabolizedBy |
CYP1A2
ⓘ
CYP2D6 ⓘ CYP3A4 ⓘ |
| wasApprovedBy |
U.S. Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: pimozide Description of subject: Pimozide is a typical antipsychotic medication primarily used to treat Tourette’s disorder and severe tics.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.