BCRP
E241383
ATP-binding cassette transporter
drug transporter
efflux transporter
membrane protein
multidrug resistance protein
BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.
All labels observed (6)
| Label | Occurrences |
|---|---|
| BCRP canonical | 4 |
| breast cancer resistance protein | 3 |
| ABCG2 | 1 |
| ATP-binding cassette sub-family G member 2 | 1 |
| ATP-binding cassette transporter family | 1 |
| Breast Cancer Resistance Protein | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2190671 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: BCRP Context triple: [Xarelto, isSubstrateOf, BCRP]
-
A.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
B.
BRC
BRC is the commonly used abbreviation for Black Rock City, the temporary city built annually in Nevada’s Black Rock Desert for the Burning Man festival.
-
C.
BRC
BRC is the IATA airport code for San Carlos de Bariloche’s main international airport in Argentina.
-
D.
BCRI
BCRI is a cultural and educational institution in Birmingham, Alabama that documents and promotes understanding of the American civil rights movement and ongoing struggles for human rights.
-
E.
BCH
BCH is a leading pediatric medical center and teaching hospital in Boston renowned for its specialized care for children and groundbreaking research.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: BCRP Target entity description: BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.
-
A.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
B.
BRC
BRC is the commonly used abbreviation for Black Rock City, the temporary city built annually in Nevada’s Black Rock Desert for the Burning Man festival.
-
C.
BRC
BRC is the IATA airport code for San Carlos de Bariloche’s main international airport in Argentina.
-
D.
BCRI
BCRI is a cultural and educational institution in Birmingham, Alabama that documents and promotes understanding of the American civil rights movement and ongoing struggles for human rights.
-
E.
BCH
BCH is a leading pediatric medical center and teaching hospital in Boston renowned for its specialized care for children and groundbreaking research.
- F. None of above. chosen
Statements (52)
| Predicate | Object |
|---|---|
| instanceOf |
ATP-binding cassette transporter
ⓘ
drug transporter ⓘ efflux transporter ⓘ membrane protein ⓘ multidrug resistance protein ⓘ |
| alsoKnownAs |
ABCG2
ⓘ
linked to:
BCRP
ATP-binding cassette sub-family G member 2 ⓘ
linked to:
BCRP
Breast Cancer Resistance Protein ⓘ
linked to:
BCRP
|
| associatedWith |
chemotherapy resistance
ⓘ
gout susceptibility via urate transport ⓘ reduced intracellular drug accumulation ⓘ |
| belongsToFamily |
ATP-binding cassette transporter family
ⓘ
linked to:
BCRP
|
| belongsToSubfamily | ABC subfamily G ⓘ |
| biologicalRole |
contribution to pharmacokinetic variability
ⓘ
efflux of drugs ⓘ efflux of xenobiotics ⓘ limitation of oral drug absorption ⓘ modulation of drug disposition ⓘ multidrug resistance in cancer cells ⓘ protection of tissues from toxic compounds ⓘ |
| containsDomain | nucleotide-binding domain ⓘ |
| effectOfPolymorphism |
altered drug pharmacokinetics
ⓘ
altered transporter expression ⓘ |
| encodedBy | ABCG2 gene ⓘ |
| inhibitedBy |
Ko143
ⓘ
cyclosporine A ⓘ elacridar ⓘ tyrosine kinase inhibitors ⓘ |
| localization |
apical membrane of epithelial cells
ⓘ
blood–brain barrier endothelial cells ⓘ hematopoietic stem cells ⓘ intestinal epithelium ⓘ kidney proximal tubule epithelium ⓘ liver canalicular membrane ⓘ placental syncytiotrophoblast ⓘ plasma membrane ⓘ |
| organism | Homo sapiens ⓘ |
| polymorphism | ABCG2 c.421C>A (Q141K) ⓘ |
| structure | half-transporter requiring homodimerization ⓘ |
| substrateOf |
estrone-3-sulfate
ⓘ
fluoroquinolone antibiotics ⓘ imatinib ⓘ irinotecan and its metabolites ⓘ methotrexate ⓘ mitoxantrone ⓘ rosuvastatin ⓘ sulfasalazine ⓘ topotecan ⓘ uric acid ⓘ |
| topology | six transmembrane helices per monomer ⓘ |
| transportMechanism | ATP-dependent efflux ⓘ |
| usesEnergyFrom | ATP hydrolysis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: BCRP Description of subject: BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.
Referenced by (11)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: BCRP
linked to: BCRP
linked to: BCRP
linked to: BCRP
linked to: BCRP
subject linked to:
ABCG2 gene