Xeloda
E238181
Xeloda is an oral chemotherapy drug (capecitabine) commonly used to treat various cancers, including colorectal and breast cancer.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Xeloda canonical | 1 |
| capecitabine | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2138518 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Xeloda Context triple: [Roche, product, Xeloda]
-
A.
Alimta
Alimta is a chemotherapy drug (pemetrexed) primarily used to treat malignant pleural mesothelioma and non-small cell lung cancer.
-
B.
Avastin
Avastin is a widely used cancer drug (bevacizumab) that inhibits angiogenesis by targeting vascular endothelial growth factor (VEGF).
-
C.
Verzenio
Verzenio is a prescription cancer medication (abemaciclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative breast cancer.
-
D.
Herceptin
Herceptin is a targeted monoclonal antibody drug used primarily to treat HER2-positive breast cancer by blocking the HER2 receptor on cancer cells.
-
E.
Imbruvica
Imbruvica is a targeted cancer therapy (a Bruton's tyrosine kinase inhibitor) used primarily to treat certain types of blood cancers such as mantle cell lymphoma and chronic lymphocytic leukemia.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Xeloda Target entity description: Xeloda is an oral chemotherapy drug (capecitabine) commonly used to treat various cancers, including colorectal and breast cancer.
-
A.
Alimta
Alimta is a chemotherapy drug (pemetrexed) primarily used to treat malignant pleural mesothelioma and non-small cell lung cancer.
-
B.
Avastin
Avastin is a widely used cancer drug (bevacizumab) that inhibits angiogenesis by targeting vascular endothelial growth factor (VEGF).
-
C.
Verzenio
Verzenio is a prescription cancer medication (abemaciclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative breast cancer.
-
D.
Herceptin
Herceptin is a targeted monoclonal antibody drug used primarily to treat HER2-positive breast cancer by blocking the HER2 receptor on cancer cells.
-
E.
Imbruvica
Imbruvica is a targeted cancer therapy (a Bruton's tyrosine kinase inhibitor) used primarily to treat certain types of blood cancers such as mantle cell lymphoma and chronic lymphocytic leukemia.
- F. None of above. chosen
Statements (57)
| Predicate | Object |
|---|---|
| instanceOf |
antimetabolite
ⓘ
chemotherapy drug ⓘ fluoropyrimidine ⓘ pharmaceutical drug ⓘ |
| hasActiveIngredient | capecitabine ⓘ |
| hasApprovalAgency |
European Medicines Agency
ⓘ
U.S. Food and Drug Administration ⓘ
linked to:
Food and Drug Administration
|
| hasATCCode | L01BC06 ⓘ |
| hasBlackBoxWarning | may cause serious and fatal adverse reactions similar to fluorouracil ⓘ |
| hasCommonSideEffect |
abdominal pain
ⓘ
anorexia ⓘ diarrhea ⓘ fatigue ⓘ hand‑foot syndrome ⓘ nausea ⓘ rash ⓘ stomatitis ⓘ vomiting ⓘ |
| hasDosageForm | film‑coated tablet ⓘ |
| hasGenericName | capecitabine ⓘ |
| hasMechanismOfAction |
inhibits DNA synthesis in rapidly dividing cells
ⓘ
interferes with RNA processing and function ⓘ prodrug of 5‑fluorouracil ⓘ |
| hasPregnancyCategory | D (US, historical classification) ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| hasSeriousAdverseEffect |
cardiotoxicity
ⓘ
hepatic dysfunction ⓘ myelosuppression ⓘ severe diarrhea ⓘ severe skin reactions ⓘ |
| hasTypicalDosingSchedule | twice daily for 14 days followed by 7 days rest in 21‑day cycles ⓘ |
| interactsWith |
folinic acid (leucovorin)
ⓘ
phenytoin ⓘ warfarin ⓘ |
| isActivatedPreferentiallyIn | tumor tissue ⓘ |
| isAvailableAs |
brand‑name drug
ⓘ
generic drug ⓘ |
| isContraindicatedIn |
known hypersensitivity to capecitabine
ⓘ
known hypersensitivity to fluorouracil ⓘ severe renal impairment ⓘ |
| isConvertedTo | 5‑fluorouracil ⓘ |
| isIndicatedFor |
adjuvant treatment of colon cancer
ⓘ
breast cancer ⓘ colorectal cancer ⓘ metastatic breast cancer ⓘ metastatic colorectal cancer ⓘ |
| isIndicatedForUseWith | docetaxel in metastatic breast cancer after anthracycline failure ⓘ |
| isManufacturedBy |
Hoffmann‑La Roche
ⓘ
linked to:
Roche
|
| isMetabolizedPrimarilyIn | liver ⓘ |
| isTeratogenic | true ⓘ |
| isUsedAs |
combination therapy in colorectal cancer
ⓘ
monotherapy in colorectal cancer ⓘ monotherapy in metastatic breast cancer ⓘ |
| requiresDoseAdjustmentIn | renal impairment ⓘ |
| shouldBeUsedWithCautionIn |
elderly patients
ⓘ
patients with cardiac disease ⓘ |
| wasFirstApprovedIn | 1998 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Xeloda Description of subject: Xeloda is an oral chemotherapy drug (capecitabine) commonly used to treat various cancers, including colorectal and breast cancer.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.