APOE ε3 allele
E494101
The APOE ε3 allele is the most common and generally considered the “neutral” variant of the apolipoprotein E gene, associated with average risk for Alzheimer’s disease and typical lipid metabolism compared to other APOE alleles.
All labels observed (3)
| Label | Occurrences |
|---|---|
| APOE ε3 | 2 |
| APOE ε3 allele canonical | 1 |
| apolipoprotein E3 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T5114823 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: APOE ε3 allele Context triple: [APOE ε4 allele, differsFrom, APOE ε3 allele]
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A.
APOE ε4 allele
The APOE ε4 allele is a genetic variant of the apolipoprotein E gene that significantly increases an individual's susceptibility to late-onset Alzheimer's disease.
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B.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
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C.
AP3A
AP3A is a scholarly journal series publishing peer-reviewed archaeological research under the American Anthropological Association.
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D.
Multi-Ethnic Study of Atherosclerosis
The Multi-Ethnic Study of Atherosclerosis is a long-term, population-based medical research study that investigates the prevalence, progression, and risk factors of cardiovascular disease across diverse ethnic groups in the United States.
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E.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: APOE ε3 allele Target entity description: The APOE ε3 allele is the most common and generally considered the “neutral” variant of the apolipoprotein E gene, associated with average risk for Alzheimer’s disease and typical lipid metabolism compared to other APOE alleles.
-
A.
APOE ε4 allele
The APOE ε4 allele is a genetic variant of the apolipoprotein E gene that significantly increases an individual's susceptibility to late-onset Alzheimer's disease.
-
B.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
C.
AP3A
AP3A is a scholarly journal series publishing peer-reviewed archaeological research under the American Anthropological Association.
-
D.
Multi-Ethnic Study of Atherosclerosis
The Multi-Ethnic Study of Atherosclerosis is a long-term, population-based medical research study that investigates the prevalence, progression, and risk factors of cardiovascular disease across diverse ethnic groups in the United States.
-
E.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
- F. None of above. chosen
Statements (48)
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: APOE ε3 allele Description of subject: The APOE ε3 allele is the most common and generally considered the “neutral” variant of the apolipoprotein E gene, associated with average risk for Alzheimer’s disease and typical lipid metabolism compared to other APOE alleles.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: APOE ε3 allele
linked to: APOE ε3 allele