lamotrigine
E874311
Lamotrigine is an anticonvulsant medication primarily used to treat epilepsy and bipolar disorder by stabilizing neuronal activity and reducing the frequency of seizures or mood episodes.
All labels observed (1)
| Label | Occurrences |
|---|---|
| lamotrigine canonical | 4 |
How this entity was disambiguated
This entity first appeared as the object of triple T10609987 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: lamotrigine Context triple: [Dravet syndrome, hasContraindicatedDrug, lamotrigine]
-
A.
carbamazepine
Carbamazepine is an anticonvulsant and mood-stabilizing drug commonly used to treat epilepsy, trigeminal neuralgia, and bipolar disorder.
-
B.
phenytoin
Phenytoin is an antiepileptic medication commonly used to prevent and control seizures by stabilizing neuronal activity in the brain.
-
C.
Lyrica
Lyrica is a prescription medication (pregabalin) commonly used to treat nerve pain, fibromyalgia, and certain types of seizures.
-
D.
Lamotrek
Lamotrek is a small atoll in the Federated States of Micronesia known for its traditional seafaring culture and navigational expertise.
-
E.
Acurenam
Acurenam is a town located in the Centro Sur province of Equatorial Guinea.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: lamotrigine Target entity description: Lamotrigine is an anticonvulsant medication primarily used to treat epilepsy and bipolar disorder by stabilizing neuronal activity and reducing the frequency of seizures or mood episodes.
-
A.
carbamazepine
Carbamazepine is an anticonvulsant and mood-stabilizing drug commonly used to treat epilepsy, trigeminal neuralgia, and bipolar disorder.
-
B.
phenytoin
Phenytoin is an antiepileptic medication commonly used to prevent and control seizures by stabilizing neuronal activity in the brain.
-
C.
Lyrica
Lyrica is a prescription medication (pregabalin) commonly used to treat nerve pain, fibromyalgia, and certain types of seizures.
-
D.
Lamotrek
Lamotrek is a small atoll in the Federated States of Micronesia known for its traditional seafaring culture and navigational expertise.
-
E.
Acurenam
Acurenam is a town located in the Centro Sur province of Equatorial Guinea.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
anticonvulsant drug
ⓘ
antiepileptic drug ⓘ mood stabilizer ⓘ pharmaceutical drug ⓘ |
| administeredBy | oral route ⓘ |
| approvedForMedicalUseIn | 1994 in the United States ⓘ |
| availableAs |
chewable dispersible tablets
ⓘ
extended-release tablets ⓘ immediate-release tablets ⓘ |
| belongsToClass | phenyltriazines ⓘ |
| clearanceIncreasedBy | enzyme-inducing antiepileptic drugs ⓘ |
| commonAdverseEffect |
dizziness
ⓘ
headache ⓘ insomnia ⓘ nausea ⓘ rash ⓘ |
| contraindicatedIn | known hypersensitivity to lamotrigine ⓘ |
| developedBy | GlaxoSmithKline ⓘ |
| discoveredIn | 1980s ⓘ |
| entersBreastMilk | true ⓘ |
| excretedBy | kidneys ⓘ |
| hasATCCode | N03AX09 ⓘ |
| hasBioavailability | approximately 98 percent ⓘ |
| hasCASNumber | 84057-84-1 ⓘ |
| hasChemicalFormula | C9H7Cl2N5O ⓘ |
| hasEliminationHalfLife | approximately 25 hours in adults ⓘ |
| hasIUPACName | 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine ⓘ |
| hasProteinBinding | approximately 55 percent ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| legalStatus | prescription-only medicine ⓘ |
| mechanismOfAction |
blocks voltage-gated sodium channels
ⓘ
inhibits glutamate release ⓘ reduces excitatory neurotransmission ⓘ stabilizes neuronal membranes ⓘ |
| metabolizedBy | hepatic glucuronidation ⓘ |
| passesPlacenta | true ⓘ |
| pregnancyCategory | varies by jurisdiction ⓘ |
| requires | slow dose titration ⓘ |
| riskIncreasedBy | coadministration with valproate ⓘ |
| seriousAdverseEffect |
Stevens–Johnson syndrome
ⓘ
drug reaction with eosinophilia and systemic symptoms ⓘ toxic epidermal necrolysis ⓘ |
| usedFor |
Lennox–Gastaut syndrome
ⓘ
linked to:
Lennox-Gastaut syndrome
bipolar disorder ⓘ epilepsy ⓘ focal seizures ⓘ generalized tonic-clonic seizures ⓘ maintenance treatment of bipolar I disorder ⓘ prevention of depressive episodes in bipolar disorder ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: lamotrigine Description of subject: Lamotrigine is an anticonvulsant medication primarily used to treat epilepsy and bipolar disorder by stabilizing neuronal activity and reducing the frequency of seizures or mood episodes.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.