Lennox-Gastaut syndrome
E278053
Lennox-Gastaut syndrome is a severe, childhood-onset epileptic encephalopathy characterized by multiple types of drug-resistant seizures, cognitive impairment, and abnormal EEG findings.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Lennox-Gastaut syndrome canonical | 6 |
| Lennox–Gastaut syndrome | 3 |
How this entity was disambiguated
This entity first appeared as the object of triple T2523477 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Lennox-Gastaut syndrome Context triple: [CBD, EpidiolexIndication, Lennox-Gastaut syndrome]
-
A.
Dravet syndrome
Dravet syndrome is a rare, severe form of early-onset epilepsy characterized by prolonged, drug-resistant seizures and developmental delays, typically beginning in infancy.
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B.
Huntington's chorea
Huntington's chorea is a hereditary neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms, typically manifesting in mid-adulthood.
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C.
Dyskolos
Dyskolos is an ancient Greek comedy by the playwright Menander, renowned as one of the best-preserved examples of New Comedy.
-
D.
BHD
BHD is the IATA airport code for George Best Belfast City Airport, a major regional airport serving Belfast, Northern Ireland.
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E.
Epidiolex
Epidiolex is a prescription cannabidiol-based medication used to treat certain rare and severe forms of epilepsy.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Lennox-Gastaut syndrome Target entity description: Lennox-Gastaut syndrome is a severe, childhood-onset epileptic encephalopathy characterized by multiple types of drug-resistant seizures, cognitive impairment, and abnormal EEG findings.
-
A.
Dravet syndrome
Dravet syndrome is a rare, severe form of early-onset epilepsy characterized by prolonged, drug-resistant seizures and developmental delays, typically beginning in infancy.
-
B.
Huntington's chorea
Huntington's chorea is a hereditary neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms, typically manifesting in mid-adulthood.
-
C.
Dyskolos
Dyskolos is an ancient Greek comedy by the playwright Menander, renowned as one of the best-preserved examples of New Comedy.
-
D.
BHD
BHD is the IATA airport code for George Best Belfast City Airport, a major regional airport serving Belfast, Northern Ireland.
-
E.
Epidiolex
Epidiolex is a prescription cannabidiol-based medication used to treat certain rare and severe forms of epilepsy.
- F. None of above. chosen
Statements (60)
| Predicate | Object |
|---|---|
| instanceOf |
epilepsy syndrome
ⓘ
epileptic encephalopathy ⓘ neurological disorder ⓘ rare disease ⓘ |
| associatedWith |
autism spectrum features
ⓘ
behavioral disturbances ⓘ injuries from drop attacks ⓘ intellectual disability ⓘ sleep disturbances ⓘ status epilepticus ⓘ |
| belongsToCategory |
developmental and epileptic encephalopathies
ⓘ
generalized epilepsies ⓘ |
| characterizedBy |
abnormal EEG findings
ⓘ
behavioral problems ⓘ cognitive impairment ⓘ developmental delay ⓘ drug-resistant seizures ⓘ multiple seizure types ⓘ |
| hasAbbreviation | LGS ⓘ |
| hasCourse |
chronic
ⓘ
often progressive ⓘ |
| hasEEGPattern |
paroxysmal fast activity in sleep
ⓘ
slow spike-and-wave discharges ⓘ |
| hasEtiology |
central nervous system infections
ⓘ
genetic causes ⓘ hypoxic-ischemic encephalopathy ⓘ may be cryptogenic ⓘ metabolic disorders ⓘ perinatal brain injury ⓘ structural brain abnormalities ⓘ tuberous sclerosis complex ⓘ |
| hasICD10Code | G40.4 ⓘ |
| hasImpactOn |
cognitive development
ⓘ
motor development ⓘ quality of life ⓘ |
| hasOnset | childhood ⓘ |
| hasOrphanetID | ORPHA:2382 ⓘ |
| hasPrognosis | generally poor ⓘ |
| hasSeizureOnsetPattern | frequent daily seizures ⓘ |
| hasTypicalSeizureType |
atonic seizures
ⓘ
atypical absence seizures ⓘ focal seizures ⓘ generalized tonic-clonic seizures ⓘ myoclonic seizures ⓘ tonic seizures ⓘ |
| isOften | treatment-resistant ⓘ |
| namedAfter |
Henri Gastaut
ⓘ
William G. Lennox ⓘ |
| treatedWith |
cannabidiol
ⓘ
clobazam ⓘ corpus callosotomy ⓘ felbamate ⓘ ketogenic diet ⓘ lamotrigine ⓘ rufinamide ⓘ topiramate ⓘ vagus nerve stimulation ⓘ valproate ⓘ |
| typicalAgeOfOnset |
between 1 and 8 years
ⓘ
peak around 3 to 5 years ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Lennox-Gastaut syndrome Description of subject: Lennox-Gastaut syndrome is a severe, childhood-onset epileptic encephalopathy characterized by multiple types of drug-resistant seizures, cognitive impairment, and abnormal EEG findings.
Referenced by (9)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Lennox-Gastaut syndrome
subject linked to:
clobazam
linked to: Lennox-Gastaut syndrome
linked to: Lennox-Gastaut syndrome