clobazam
E874303
Clobazam is a benzodiazepine medication primarily used as an anticonvulsant to treat certain types of epilepsy, including Lennox-Gastaut syndrome.
All labels observed (1)
| Label | Occurrences |
|---|---|
| clobazam canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10609913 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: clobazam Context triple: [Epidiolex, drugInteractionWith, clobazam]
-
A.
carbamazepine
Carbamazepine is an anticonvulsant and mood-stabilizing drug commonly used to treat epilepsy, trigeminal neuralgia, and bipolar disorder.
-
B.
phenytoin
Phenytoin is an antiepileptic medication commonly used to prevent and control seizures by stabilizing neuronal activity in the brain.
-
C.
Acurenam
Acurenam is a town located in the Centro Sur province of Equatorial Guinea.
-
D.
Bunefer
Bunefer was an ancient Egyptian queen of the late Fourth Dynasty, likely known from her tomb at Giza and associated with the royal family of that period.
-
E.
Cobenzl
Cobenzl is the noble family name of an influential Austrian aristocratic lineage prominent in Habsburg-era diplomacy and politics.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: clobazam Target entity description: Clobazam is a benzodiazepine medication primarily used as an anticonvulsant to treat certain types of epilepsy, including Lennox-Gastaut syndrome.
-
A.
carbamazepine
Carbamazepine is an anticonvulsant and mood-stabilizing drug commonly used to treat epilepsy, trigeminal neuralgia, and bipolar disorder.
-
B.
phenytoin
Phenytoin is an antiepileptic medication commonly used to prevent and control seizures by stabilizing neuronal activity in the brain.
-
C.
Acurenam
Acurenam is a town located in the Centro Sur province of Equatorial Guinea.
-
D.
Bunefer
Bunefer was an ancient Egyptian queen of the late Fourth Dynasty, likely known from her tomb at Giza and associated with the royal family of that period.
-
E.
Cobenzl
Cobenzl is the noble family name of an influential Austrian aristocratic lineage prominent in Habsburg-era diplomacy and politics.
- F. None of above. chosen
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf |
GABAergic drug
ⓘ
anticonvulsant drug ⓘ anxiolytic drug ⓘ benzodiazepine ⓘ |
| bindsTo | GABAA receptor benzodiazepine site ⓘ |
| hasActiveMetabolite | N-desmethylclobazam ⓘ |
| hasATCCode | N03AE01 ⓘ |
| hasBlackBoxWarningUS | risks from concomitant use with opioids ⓘ |
| hasBrandName |
Frisium
ⓘ
Onfi ⓘ |
| hasCASNumber | 22316-47-8 ⓘ |
| hasChemicalClass | 1,5-benzodiazepine ⓘ |
| hasCommonSideEffect |
aggression (especially in children)
ⓘ
ataxia ⓘ constipation ⓘ drooling ⓘ lethargy ⓘ sedation ⓘ somnolence ⓘ |
| hasContraindication |
history of benzodiazepine hypersensitivity
ⓘ
myasthenia gravis ⓘ severe hepatic impairment ⓘ severe respiratory insufficiency ⓘ |
| hasDrugInteraction |
alcohol
ⓘ
opioids ⓘ other CNS depressants ⓘ strong CYP2C19 inhibitors ⓘ |
| hasEliminationHalfLife |
10–50 hours (parent drug)
ⓘ
36–42 hours (N-desmethylclobazam, approximate) ⓘ |
| hasIndication |
Lennox-Gastaut syndrome
ⓘ
adjunctive treatment of seizures ⓘ anxiety disorders (in some countries) ⓘ epilepsy ⓘ |
| hasIUPACName | 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-dione ⓘ |
| hasLegalStatusInUS | prescription only ⓘ |
| hasMechanismOfAction | positive allosteric modulator of GABAA receptor ⓘ |
| hasMolecularFormula | C16H13ClN2O2 ⓘ |
| hasPregnancyCategoryUS | C ⓘ |
| hasRisk |
abuse potential
ⓘ
suicidal ideation (class warning for antiepileptics) ⓘ tolerance with long-term use ⓘ |
| hasRouteOfAdministration |
oral
ⓘ
oral suspension ⓘ tablet ⓘ |
| hasSeriousSideEffect |
dependence
ⓘ
respiratory depression ⓘ withdrawal seizures ⓘ |
| isControlledSubstanceInUS | Schedule IV ⓘ |
| isExcretedBy |
fecal route
ⓘ
renal route ⓘ |
| isMetabolizedBy |
CYP2C19
ⓘ
CYP3A4 ⓘ |
| isPrescriptionOnly | true ⓘ |
| wasApprovedBy |
US Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: clobazam Description of subject: Clobazam is a benzodiazepine medication primarily used as an anticonvulsant to treat certain types of epilepsy, including Lennox-Gastaut syndrome.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.