probenecid
E850001
Probenecid is a uricosuric medication primarily used to treat gout and hyperuricemia and to modify the renal excretion of various drugs.
All labels observed (1)
| Label | Occurrences |
|---|---|
| probenecid canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10214503 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: probenecid Context triple: [methotrexate, interactsWith, probenecid]
-
A.
Fenodyree
Fenodyree is a mythical, goblin-like creature from Alan Garner’s fantasy novel "The Weirdstone of Brisingamen," known for aiding the protagonists with its otherworldly powers and knowledge of the hidden realms.
-
B.
Bunefer
Bunefer was an ancient Egyptian queen of the late Fourth Dynasty, likely known from her tomb at Giza and associated with the royal family of that period.
-
C.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
-
D.
Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
-
E.
Bkeftine
Bkeftine is a village located in the Koura District of northern Lebanon, known for its rural character and olive groves.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: probenecid Target entity description: Probenecid is a uricosuric medication primarily used to treat gout and hyperuricemia and to modify the renal excretion of various drugs.
-
A.
Fenodyree
Fenodyree is a mythical, goblin-like creature from Alan Garner’s fantasy novel "The Weirdstone of Brisingamen," known for aiding the protagonists with its otherworldly powers and knowledge of the hidden realms.
-
B.
Bunefer
Bunefer was an ancient Egyptian queen of the late Fourth Dynasty, likely known from her tomb at Giza and associated with the royal family of that period.
-
C.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
-
D.
Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
-
E.
Bkeftine
Bkeftine is a village located in the Koura District of northern Lebanon, known for its rural character and olive groves.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
gout medication
ⓘ
organic acid ⓘ pharmaceutical drug ⓘ small molecule ⓘ uricosuric agent ⓘ |
| actsOnTarget |
OAT1 transporter
ⓘ
OAT3 transporter ⓘ URAT1 transporter ⓘ |
| hasATCCode | M04AB01 ⓘ |
| hasBioavailability | high oral bioavailability ⓘ |
| hasCASNumber | 57-66-9 ⓘ |
| hasChemicalFormula | C13H19NO4S ⓘ |
| hasDrugInteractionWith |
NSAIDs
ⓘ
aspirin ⓘ methotrexate ⓘ salicylates ⓘ |
| hasEliminationHalfLife | approximately 4 to 12 hours ⓘ |
| hasIUPACName | 4-[(dipropylsulfamoyl)methyl]benzoic acid ⓘ |
| hasMechanismOfAction |
inhibits organic anion transporters in renal proximal tubules
ⓘ
inhibits renal tubular reabsorption of uric acid ⓘ |
| hasMolarMass | 285.36 g/mol ⓘ |
| hasPregnancyCategory | varies by jurisdiction ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| hasTherapeuticUse |
adjunct to antibiotic therapy
ⓘ
prevention of gouty arthritis attacks ⓘ treatment of gout ⓘ treatment of hyperuricemia ⓘ |
| increasesRenalExcretionOf | uric acid ⓘ |
| increasesSerumConcentrationOf | penicillin ⓘ |
| isAdministeredAs | oral tablet ⓘ |
| isContraindicatedIn |
acute gout attack
ⓘ
severe renal impairment ⓘ uric acid kidney stones ⓘ |
| isExcretedBy | kidney ⓘ |
| isIndicatedFor |
chronic gout
ⓘ
hyperuricemia associated with gout ⓘ |
| isListedOn | World Health Organization Model List of Essential Medicines ⓘ |
| isMetabolizedBy | liver ⓘ |
| isProteinBound | high protein binding ⓘ |
| mayCauseAdverseEffect |
gastrointestinal upset
ⓘ
headache ⓘ kidney stones ⓘ rash ⓘ |
| modifiesPharmacokineticsOf |
cephalosporins
ⓘ
penicillin ⓘ
linked to:
penicillins
some antiviral drugs ⓘ |
| wasFirstApprovedIn | 1951 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: probenecid Description of subject: Probenecid is a uricosuric medication primarily used to treat gout and hyperuricemia and to modify the renal excretion of various drugs.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.