benserazide
E804591
antiparkinsonian agent
aromatic L-amino acid decarboxylase inhibitor
peripheral dopa decarboxylase inhibitor
pharmaceutical drug
Benserazide is a peripheral dopa decarboxylase inhibitor used in combination with levodopa to enhance its effectiveness and reduce side effects in the treatment of Parkinson’s disease.
All labels observed (1)
| Label | Occurrences |
|---|---|
| benserazide canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T9524765 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: benserazide Context triple: [levodopa, oftenCombinedWith, benserazide]
-
A.
Benso
Benso is the aristocratic family name of Camillo Benso, Count of Cavour, a leading statesman of the Italian unification.
-
B.
Bunefer
Bunefer was an ancient Egyptian queen of the late Fourth Dynasty, likely known from her tomb at Giza and associated with the royal family of that period.
-
C.
BZD
BZD is the currency code for the Belize dollar, the official monetary unit of Belize.
-
D.
Cobenzl
Cobenzl is the noble family name of an influential Austrian aristocratic lineage prominent in Habsburg-era diplomacy and politics.
-
E.
Panazol
Panazol is a suburban commune in west-central France, located just east of the city of Limoges in the Nouvelle-Aquitaine region.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: benserazide Target entity description: Benserazide is a peripheral dopa decarboxylase inhibitor used in combination with levodopa to enhance its effectiveness and reduce side effects in the treatment of Parkinson’s disease.
-
A.
Benso
Benso is the aristocratic family name of Camillo Benso, Count of Cavour, a leading statesman of the Italian unification.
-
B.
Bunefer
Bunefer was an ancient Egyptian queen of the late Fourth Dynasty, likely known from her tomb at Giza and associated with the royal family of that period.
-
C.
BZD
BZD is the currency code for the Belize dollar, the official monetary unit of Belize.
-
D.
Cobenzl
Cobenzl is the noble family name of an influential Austrian aristocratic lineage prominent in Habsburg-era diplomacy and politics.
-
E.
Panazol
Panazol is a suburban commune in west-central France, located just east of the city of Limoges in the Nouvelle-Aquitaine region.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
antiparkinsonian agent
ⓘ
aromatic L-amino acid decarboxylase inhibitor ⓘ peripheral dopa decarboxylase inhibitor ⓘ pharmaceutical drug ⓘ |
| actsOnEnzyme | dopa decarboxylase ⓘ |
| commonAdverseEffect |
diarrhea
ⓘ
dyskinesia when combined with levodopa ⓘ nausea ⓘ orthostatic hypotension ⓘ vomiting ⓘ |
| contraindication |
concomitant use with non-selective MAO inhibitors
ⓘ
narrow-angle glaucoma ⓘ severe hepatic impairment ⓘ severe renal impairment ⓘ |
| crossesBloodBrainBarrier | no ⓘ |
| developedFor | enhancing levodopa therapy in Parkinson’s disease ⓘ |
| eliminationRoute | renal ⓘ |
| hasATCCode | N04BA02 ⓘ |
| hasBioavailability | low ⓘ |
| hasCASNumber | 322-35-0 ⓘ |
| hasChEMBLID | CHEMBL1082 ⓘ |
| hasChemicalFormula | C10H15N3O5 ⓘ |
| hasDrugBankID | DB01232 ⓘ |
| hasHalfLife | approximately 1.5 hours ⓘ |
| hasIUPACName | (2S)-2-amino-3-hydroxy-N'-[(2S,3R)-2,3,4-trihydroxy-3-(hydroxymethyl)butyl]propanediamide ⓘ |
| hasMolarMass | 257.246 g/mol ⓘ |
| hasPregnancyCategory | C (varies by jurisdiction) ⓘ |
| hasProteinBinding | low ⓘ |
| hasPubChemCID | 2327 ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| hasUNII | P8G79501I4 ⓘ |
| isComponentOf |
Madopar
ⓘ
linked to:
carbidopa
Prolopa ⓘ co-beneldopa ⓘ |
| legalStatusInAustralia | prescription only ⓘ |
| legalStatusInCanada | prescription only ⓘ |
| legalStatusInEuropeanUnion | prescription only ⓘ |
| legalStatusInUnitedStates | not approved ⓘ |
| mechanismOfAction | inhibits peripheral aromatic L-amino acid decarboxylase ⓘ |
| metabolism | hepatic ⓘ |
| primaryEffect |
increases availability of levodopa to the brain
ⓘ
reduces peripheral conversion of levodopa to dopamine ⓘ |
| reducesAdverseEffect |
cardiovascular side effects of levodopa
ⓘ
nausea ⓘ vomiting ⓘ |
| reducesSideEffectsOf | levodopa ⓘ |
| therapeuticUse |
treatment of Parkinson’s disease
ⓘ
treatment of parkinsonism ⓘ |
| usedInCombinationWith | levodopa ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: benserazide Description of subject: Benserazide is a peripheral dopa decarboxylase inhibitor used in combination with levodopa to enhance its effectiveness and reduce side effects in the treatment of Parkinson’s disease.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.