aromatic L-amino acid decarboxylase

E804593

decarboxylase enzyme pyridoxal phosphate–dependent enzyme

Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.

Try in SPARQL Jump to: Surface forms Disambiguation Statements Elicitation Referenced by

All labels observed (3)

Label	Occurrences
DOPA decarboxylase	1
L-dopa decarboxylase	1
aromatic L-amino acid decarboxylase canonical	1

How this entity was disambiguated

This entity first appeared as the object of triple T9524772 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: aromatic L-amino acid decarboxylase
Context triple: [levodopa, metabolizedBy, aromatic L-amino acid decarboxylase]

A. levodopa
Levodopa is a cornerstone medication for managing Parkinson’s disease symptoms by replenishing the brain’s depleted dopamine levels.
B. ase
"ase" is the ISO 639-3 language code assigned to American Sign Language, the primary sign language used by Deaf communities in the United States and parts of Canada.
C. GABA
GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system, crucial for reducing neuronal excitability and regulating muscle tone and anxiety.
D. Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
E. MAO
MAO is a contemporary art gallery and exhibition space in Oxford, England, known for showcasing innovative modern and contemporary art.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: aromatic L-amino acid decarboxylase
Target entity description: Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.

A. levodopa
Levodopa is a cornerstone medication for managing Parkinson’s disease symptoms by replenishing the brain’s depleted dopamine levels.
B. ase
"ase" is the ISO 639-3 language code assigned to American Sign Language, the primary sign language used by Deaf communities in the United States and parts of Canada.
C. GABA
GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system, crucial for reducing neuronal excitability and regulating muscle tone and anxiety.
D. Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
E. MAO
MAO is a contemporary art gallery and exhibition space in Oxford, England, known for showcasing innovative modern and contemporary art.
F. None of above. chosen

Statements (50)

Predicate	Object
instanceOf	decarboxylase ⓘ enzyme ⓘ pyridoxal phosphate–dependent enzyme ⓘ
associatedWithDisease	Parkinson's disease ⓘ aromatic L-amino acid decarboxylase deficiency ⓘ dopamine-serotonin deficiency syndrome ⓘ
catalyzesReaction	5-hydroxy-L-tryptophan + H+ → serotonin + CO2 ⓘ L-DOPA + H+ → dopamine + CO2 ⓘ L-phenylalanine + H+ → phenethylamine + CO2 ⓘ L-tryptophan + H+ → tryptamine + CO2 ⓘ L-tyrosine + H+ → tyramine + CO2 ⓘ
cellularLocation	cytosol ⓘ
chromosomalLocationOfGene	human chromosome 7p12.2 ⓘ
encodedByGene	DDC gene ⓘ
formsComplex	homodimer ⓘ
foundInOrganism	Homo sapiens ⓘ Mus musculus ⓘ linked to: house mouse (Mus musculus) Rattus norvegicus ⓘ linked to: Norway rat (Rattus norvegicus)
foundInTissue	brain ⓘ pancreatic islets ⓘ peripheral nervous system ⓘ
hasCofactor	pyridoxal 5'-phosphate ⓘ
hasECNumber	4.1.1.28 ⓘ
hasEnzymeClassification	lyase ⓘ
hasEnzymeCommissionClass	carboxy-lyases ⓘ
hasSynonym	AADC ⓘ DDC ⓘ DOPA decarboxylase ⓘ linked to: aromatic L-amino acid decarboxylase L-dopa decarboxylase ⓘ linked to: aromatic L-amino acid decarboxylase aromatic L-amino-acid decarboxylase ⓘ
isTargetOfDrug	benserazide ⓘ carbidopa ⓘ methyldopa ⓘ
molecularFunction	aromatic-L-amino-acid decarboxylase activity ⓘ
participatesIn	catecholamine biosynthetic process ⓘ dopamine biosynthetic process ⓘ monoamine neurotransmitter biosynthetic process ⓘ serotonin biosynthetic process ⓘ
product	carbon dioxide ⓘ dopamine ⓘ phenethylamine ⓘ serotonin ⓘ tryptamine ⓘ tyramine ⓘ
requires	pyridoxal phosphate ⓘ
substrate	5-hydroxy-L-tryptophan ⓘ L-DOPA ⓘ L-phenylalanine ⓘ L-tryptophan ⓘ L-tyrosine ⓘ

How these facts were elicited

Referenced by (3)

Full triples — surface form annotated when it differs from this entity's canonical label.

levodopa → metabolizedBy → aromatic L-amino acid decarboxylase ⓘ

aromatic L-amino acid decarboxylase → hasSynonym → DOPA decarboxylase ⓘ

linked to: aromatic L-amino acid decarboxylase

aromatic L-amino acid decarboxylase → hasSynonym → L-dopa decarboxylase ⓘ