Lewy bodies
E229729
Lewy bodies are abnormal aggregates of the protein alpha-synuclein that accumulate inside neurons and are characteristic of Parkinson’s disease and related neurodegenerative disorders.
All labels observed (5)
| Label | Occurrences |
|---|---|
| Lewy bodies canonical | 4 |
| Lewy body | 1 |
| Lewy body pathology | 1 |
| Lewy neurites | 1 |
| cortical Lewy bodies | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2033063 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Lewy bodies Context triple: [Parkinson's disease, hasBiomarker, Lewy bodies]
-
A.
Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor symptoms such as tremors, rigidity, and slowed movement, caused by the loss of dopamine-producing neurons in the brain.
-
B.
Huntington's chorea
Huntington's chorea is a hereditary neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms, typically manifesting in mid-adulthood.
-
C.
MCI-Shirley
MCI-Shirley is a medium- and minimum-security state prison for men located in Shirley, Massachusetts.
-
D.
Virchow–Robin spaces
Virchow–Robin spaces are perivascular, fluid-filled spaces that surround blood vessels as they penetrate the brain, visible on neuroimaging and often associated with various neurological conditions.
-
E.
ALS
ALS (amyotrophic lateral sclerosis) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord, leading to muscle weakness, paralysis, and ultimately respiratory failure.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Lewy bodies Target entity description: Lewy bodies are abnormal aggregates of the protein alpha-synuclein that accumulate inside neurons and are characteristic of Parkinson’s disease and related neurodegenerative disorders.
-
A.
Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor symptoms such as tremors, rigidity, and slowed movement, caused by the loss of dopamine-producing neurons in the brain.
-
B.
Huntington's chorea
Huntington's chorea is a hereditary neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms, typically manifesting in mid-adulthood.
-
C.
MCI-Shirley
MCI-Shirley is a medium- and minimum-security state prison for men located in Shirley, Massachusetts.
-
D.
Virchow–Robin spaces
Virchow–Robin spaces are perivascular, fluid-filled spaces that surround blood vessels as they penetrate the brain, visible on neuroimaging and often associated with various neurological conditions.
-
E.
ALS
ALS (amyotrophic lateral sclerosis) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord, leading to muscle weakness, paralysis, and ultimately respiratory failure.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
intracytoplasmic inclusion
ⓘ
neuropathological hallmark ⓘ pathological protein aggregate ⓘ |
| associatedWith | synucleinopathies ⓘ |
| associatedWithDisease |
Lewy body disease
ⓘ
linked to:
Lewy body dementia
Parkinson's disease ⓘ Parkinson's disease dementia ⓘ
linked to:
Lewy body dementia
REM sleep behavior disorder ⓘ dementia with Lewy bodies ⓘ multiple system atrophy ⓘ |
| associatedWithSymptom |
autonomic dysfunction
ⓘ
cognitive impairment ⓘ fluctuating cognition ⓘ parkinsonism ⓘ visual hallucinations ⓘ |
| characteristicOf |
Parkinson's disease
ⓘ
dementia with Lewy bodies ⓘ |
| classifiedAs | intraneuronal inclusion body ⓘ |
| composedOf |
alpha-synuclein
ⓘ
lipids ⓘ membranous organelle remnants ⓘ neurofilament proteins ⓘ ubiquitin ⓘ |
| discoveredBy | Friedrich Heinrich Lewy ⓘ |
| firstDescribedIn | 1912 ⓘ |
| foundIn |
amygdala
ⓘ
autonomic nervous system ⓘ central nervous system ⓘ cerebral cortex ⓘ locus coeruleus ⓘ neurons ⓘ substantia nigra ⓘ |
| hasMorphology |
dense core with pale halo
ⓘ
eosinophilic cytoplasmic inclusion ⓘ |
| locatedInCellularRegion |
neuronal cytoplasm
ⓘ
neuronal soma ⓘ |
| mayOccurIn | neuronal processes ⓘ |
| namedAfter | Friedrich Heinrich Lewy ⓘ |
| partOf |
Lewy body pathology
ⓘ
linked to:
Lewy bodies
|
| pathologicalRole |
neuronal death
ⓘ
neuronal dysfunction ⓘ |
| proteinComponent |
misfolded alpha-synuclein
ⓘ
phosphorylated alpha-synuclein ⓘ |
| relatedToProcess |
impaired proteostasis
ⓘ
neurodegeneration ⓘ protein aggregation ⓘ |
| stainsWith |
alpha-synuclein immunohistochemistry
ⓘ
eosin ⓘ hematoxylin and eosin ⓘ ubiquitin immunohistochemistry ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Lewy bodies Description of subject: Lewy bodies are abnormal aggregates of the protein alpha-synuclein that accumulate inside neurons and are characteristic of Parkinson’s disease and related neurodegenerative disorders.
Referenced by (8)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Lewy bodies
linked to: Lewy bodies
linked to: Lewy bodies
linked to: Lewy bodies