Lewy body dementia
E248332
Lewy body dementia is a progressive neurodegenerative disorder characterized by cognitive decline, visual hallucinations, fluctuating alertness, and Parkinsonian movement symptoms, caused by abnormal protein deposits called Lewy bodies in the brain.
All labels observed (5)
| Label | Occurrences |
|---|---|
| Lewy body dementia canonical | 2 |
| Lewy body disease | 1 |
| Parkinson disease dementia | 1 |
| Parkinson's disease dementia | 1 |
| dementia with Lewy bodies | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2232557 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Lewy body dementia Context triple: [Robin Williams, diagnosedWith, Lewy body dementia]
-
A.
Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor symptoms such as tremors, rigidity, and slowed movement, caused by the loss of dopamine-producing neurons in the brain.
-
B.
Lewy bodies
Lewy bodies are abnormal aggregates of the protein alpha-synuclein that accumulate inside neurons and are characteristic of Parkinson’s disease and related neurodegenerative disorders.
-
C.
Alzheimer's disease
Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes, and is the most common cause of dementia in older adults.
-
D.
Huntington's chorea
Huntington's chorea is a hereditary neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms, typically manifesting in mid-adulthood.
-
E.
MCI-Shirley
MCI-Shirley is a medium- and minimum-security state prison for men located in Shirley, Massachusetts.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Lewy body dementia Target entity description: Lewy body dementia is a progressive neurodegenerative disorder characterized by cognitive decline, visual hallucinations, fluctuating alertness, and Parkinsonian movement symptoms, caused by abnormal protein deposits called Lewy bodies in the brain.
-
A.
Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor symptoms such as tremors, rigidity, and slowed movement, caused by the loss of dopamine-producing neurons in the brain.
-
B.
Lewy bodies
Lewy bodies are abnormal aggregates of the protein alpha-synuclein that accumulate inside neurons and are characteristic of Parkinson’s disease and related neurodegenerative disorders.
-
C.
Alzheimer's disease
Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes, and is the most common cause of dementia in older adults.
-
D.
Huntington's chorea
Huntington's chorea is a hereditary neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms, typically manifesting in mid-adulthood.
-
E.
MCI-Shirley
MCI-Shirley is a medium- and minimum-security state prison for men located in Shirley, Massachusetts.
- F. None of above. chosen
Statements (72)
| Predicate | Object |
|---|---|
| instanceOf |
dementia
ⓘ
neurodegenerative disease ⓘ progressive brain disorder ⓘ synucleinopathy ⓘ |
| affects |
brain
ⓘ
cerebral cortex ⓘ subcortical structures ⓘ |
| hasAlternativeName |
dementia with Lewy bodies
ⓘ
linked to:
Lewy body dementia
|
| hasBiomarker |
abnormal alpha-synuclein pathology
ⓘ
reduced dopamine transporter uptake in basal ganglia ⓘ |
| hasCause |
Lewy bodies
ⓘ
abnormal alpha-synuclein aggregation ⓘ abnormal protein deposits in the brain ⓘ |
| hasComorbidity |
Alzheimer-type amyloid plaques
ⓘ
neurofibrillary tangles ⓘ |
| hasCoreFeature |
REM sleep behavior disorder
ⓘ
fluctuating cognition with pronounced variations in attention and alertness ⓘ recurrent visual hallucinations ⓘ spontaneous parkinsonism ⓘ |
| hasCourse | progressive ⓘ |
| hasDiagnosticCriterion | dementia plus core clinical features ⓘ |
| hasOnset | insidious ⓘ |
| hasPathology |
Lewy neurites
ⓘ
linked to:
Lewy bodies
cortical Lewy bodies ⓘ
linked to:
Lewy bodies
subcortical Lewy bodies ⓘ |
| hasPrognosis |
chronic
ⓘ
life-shortening ⓘ |
| hasRiskFactor |
Parkinson disease
ⓘ
linked to:
Parkinson's disease
REM sleep behavior disorder ⓘ advanced age ⓘ family history of Lewy body disease ⓘ male sex ⓘ |
| hasSymptom |
Parkinsonian motor symptoms
ⓘ
REM sleep behavior disorder ⓘ anxiety ⓘ apathy ⓘ autonomic dysfunction ⓘ bradykinesia ⓘ cognitive decline ⓘ constipation ⓘ daytime sleepiness ⓘ delusions ⓘ dementia ⓘ depression ⓘ disorganized speech ⓘ fluctuating alertness ⓘ fluctuating cognition ⓘ impaired attention ⓘ impaired executive function ⓘ orthostatic hypotension ⓘ paranoia ⓘ postural instability ⓘ resting tremor ⓘ rigidity ⓘ sensitivity to antipsychotic medications ⓘ urinary incontinence ⓘ visual hallucinations ⓘ visuospatial impairment ⓘ |
| hasTreatment |
cholinesterase inhibitors
ⓘ
clonazepam for REM sleep behavior disorder ⓘ levodopa for parkinsonism ⓘ melatonin for REM sleep behavior disorder ⓘ |
| hasTreatmentConsideration |
avoid typical antipsychotics when possible
ⓘ
use low-dose atypical antipsychotics with caution ⓘ |
| hasTypicalAgeOfOnset | over 60 years ⓘ |
| isAssociatedWith |
Alzheimer disease pathology
ⓘ
Parkinson disease dementia ⓘ
linked to:
Parkinson's disease
|
| isClassifiedBy |
DSM-5
ⓘ
ICD-10 ⓘ
linked to:
International Classification of Diseases
|
| isDistinctFrom |
Alzheimer disease
ⓘ
linked to:
Alzheimer's disease
Parkinson disease dementia ⓘ
linked to:
Lewy body dementia
|
| wasFirstDescribedBy | Kenji Kosaka ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Lewy body dementia Description of subject: Lewy body dementia is a progressive neurodegenerative disorder characterized by cognitive decline, visual hallucinations, fluctuating alertness, and Parkinsonian movement symptoms, caused by abnormal protein deposits called Lewy bodies in the brain.
Referenced by (6)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Lewy body dementia
linked to: Lewy body dementia
linked to: Lewy body dementia
linked to: Lewy body dementia
subject linked to:
Mayor Tom Kane