multiple system atrophy
E804586
Multiple system atrophy is a rare, progressive neurodegenerative disorder characterized by a combination of autonomic failure, parkinsonism, and/or cerebellar ataxia due to widespread nervous system damage.
All labels observed (2)
| Label | Occurrences |
|---|---|
| multiple system atrophy canonical | 3 |
| Shy–Drager syndrome | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T9524660 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: multiple system atrophy Context triple: [Lewy bodies, associatedWithDisease, multiple system atrophy]
-
A.
Lewy body dementia
Lewy body dementia is a progressive neurodegenerative disorder characterized by cognitive decline, visual hallucinations, fluctuating alertness, and Parkinsonian movement symptoms, caused by abnormal protein deposits called Lewy bodies in the brain.
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B.
Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor symptoms such as tremors, rigidity, and slowed movement, caused by the loss of dopamine-producing neurons in the brain.
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C.
MND
MND is the Ministry of National Defense of the Republic of China, responsible for formulating and executing the country's defense policy and overseeing its armed forces.
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D.
MND
MND is the abbreviated name of South Korea’s Ministry of National Defense, the government body responsible for the country’s military affairs and defense policy.
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E.
Parkinson
"Parkinson" is a long-running British television talk show hosted by journalist and broadcaster Michael Parkinson, renowned for its in-depth celebrity interviews.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: multiple system atrophy Target entity description: Multiple system atrophy is a rare, progressive neurodegenerative disorder characterized by a combination of autonomic failure, parkinsonism, and/or cerebellar ataxia due to widespread nervous system damage.
-
A.
Lewy body dementia
Lewy body dementia is a progressive neurodegenerative disorder characterized by cognitive decline, visual hallucinations, fluctuating alertness, and Parkinsonian movement symptoms, caused by abnormal protein deposits called Lewy bodies in the brain.
-
B.
Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor symptoms such as tremors, rigidity, and slowed movement, caused by the loss of dopamine-producing neurons in the brain.
-
C.
MND
MND is the Ministry of National Defense of the Republic of China, responsible for formulating and executing the country's defense policy and overseeing its armed forces.
-
D.
MND
MND is the abbreviated name of South Korea’s Ministry of National Defense, the government body responsible for the country’s military affairs and defense policy.
-
E.
Parkinson
"Parkinson" is a long-running British television talk show hosted by journalist and broadcaster Michael Parkinson, renowned for its in-depth celebrity interviews.
- F. None of above. chosen
Statements (62)
| Predicate | Object |
|---|---|
| instanceOf |
movement disorder
ⓘ
neurodegenerative disease ⓘ rare disease ⓘ synucleinopathy ⓘ |
| affectsSystem |
autonomic nervous system
ⓘ
linked to:
Autonomic nervous system
central nervous system ⓘ cerebellar system ⓘ extrapyramidal motor system ⓘ |
| hasAbbreviation | MSA ⓘ |
| hasCause | abnormal alpha-synuclein aggregation ⓘ |
| hasClinicalFeature |
REM sleep behavior disorder
ⓘ
linked to:
Parasomnias
autonomic failure ⓘ cerebellar ataxia ⓘ constipation ⓘ dysarthria ⓘ dysphagia ⓘ erectile dysfunction ⓘ gait disturbance ⓘ orthostatic hypotension ⓘ parkinsonism ⓘ postural instability ⓘ pyramidal signs ⓘ stridor ⓘ urinary incontinence ⓘ urinary retention ⓘ |
| hasCourse | progressive ⓘ |
| hasDiagnosticMethod |
autonomic function testing
ⓘ
brain MRI ⓘ clinical evaluation ⓘ |
| hasEpidemiology | rare ⓘ |
| hasFirstDescription | 1960s as Shy–Drager syndrome ⓘ |
| hasImagingFinding |
cerebellar atrophy
ⓘ
hot cross bun sign ⓘ pontine atrophy ⓘ putaminal atrophy ⓘ |
| hasMedianSurvival | 6 to 10 years after symptom onset ⓘ |
| hasNoTreatment | disease-modifying therapy currently unavailable ⓘ |
| hasOnset | adult ⓘ |
| hasPathology |
glial cytoplasmic inclusions
ⓘ
oligodendroglial alpha-synuclein inclusions ⓘ |
| hasPrevalence | approximately 3 to 5 per 100000 people ⓘ |
| hasPrognosis | poor ⓘ |
| hasRiskFactor |
environmental factors not well defined
ⓘ
possible genetic susceptibility ⓘ |
| hasSexRatio | slight male predominance ⓘ |
| hasSubtype |
MSA-C
ⓘ
MSA-P ⓘ
linked to:
MSA
cerebellar type multiple system atrophy ⓘ parkinsonian type multiple system atrophy ⓘ |
| hasSynonym |
Shy–Drager syndrome
ⓘ
linked to:
multiple system atrophy
olivopontocerebellar atrophy ⓘ striatonigral degeneration ⓘ |
| hasTreatment |
autonomic support measures
ⓘ
dopaminergic therapy with limited response ⓘ symptomatic treatment ⓘ |
| hasTreatmentGoal | symptom control ⓘ |
| hasTypicalAgeOfOnset | 50 to 60 years ⓘ |
| isClassifiedAs | orphan disease ⓘ |
| isDistinctFrom |
Parkinson's disease
ⓘ
dementia with Lewy bodies ⓘ pure autonomic failure ⓘ |
| isIncludedIn | atypical parkinsonian syndromes ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: multiple system atrophy Description of subject: Multiple system atrophy is a rare, progressive neurodegenerative disorder characterized by a combination of autonomic failure, parkinsonism, and/or cerebellar ataxia due to widespread nervous system damage.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: multiple system atrophy