alpha-synuclein

E804584

neuronal protein protein

Alpha-synuclein is a neuronal protein whose abnormal aggregation is a hallmark of Parkinson’s disease and related synucleinopathies.

Try in SPARQL Jump to: Surface forms Disambiguation Statements Elicitation Referenced by

All labels observed (3)

Label	Occurrences
SNCA gene	1
alpha-synuclein canonical	1
non-Aβ component of Alzheimer disease amyloid	1

How this entity was disambiguated

This entity first appeared as the object of triple T9524645 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: alpha-synuclein
Context triple: [Lewy bodies, composedOf, alpha-synuclein]

A. Lewy bodies
Lewy bodies are abnormal aggregates of the protein alpha-synuclein that accumulate inside neurons and are characteristic of Parkinson’s disease and related neurodegenerative disorders.
B. SOD1
SOD1 is a gene encoding the antioxidant enzyme superoxide dismutase 1, whose mutations are a major known cause of familial amyotrophic lateral sclerosis (ALS).
C. TDP-43 proteinopathy
TDP-43 proteinopathy is a neurodegenerative condition characterized by abnormal aggregation and mislocalization of the TDP-43 protein, commonly implicated in disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
D. Lewy body dementia
Lewy body dementia is a progressive neurodegenerative disorder characterized by cognitive decline, visual hallucinations, fluctuating alertness, and Parkinsonian movement symptoms, caused by abnormal protein deposits called Lewy bodies in the brain.
E. survival motor neuron protein
Survival motor neuron protein is an essential cellular protein required for the maintenance and function of motor neurons, whose deficiency leads to spinal muscular atrophy.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: alpha-synuclein
Target entity description: Alpha-synuclein is a neuronal protein whose abnormal aggregation is a hallmark of Parkinson’s disease and related synucleinopathies.

A. Lewy bodies
Lewy bodies are abnormal aggregates of the protein alpha-synuclein that accumulate inside neurons and are characteristic of Parkinson’s disease and related neurodegenerative disorders.
B. SOD1
SOD1 is a gene encoding the antioxidant enzyme superoxide dismutase 1, whose mutations are a major known cause of familial amyotrophic lateral sclerosis (ALS).
C. TDP-43 proteinopathy
TDP-43 proteinopathy is a neurodegenerative condition characterized by abnormal aggregation and mislocalization of the TDP-43 protein, commonly implicated in disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
D. Lewy body dementia
Lewy body dementia is a progressive neurodegenerative disorder characterized by cognitive decline, visual hallucinations, fluctuating alertness, and Parkinsonian movement symptoms, caused by abnormal protein deposits called Lewy bodies in the brain.
E. survival motor neuron protein
Survival motor neuron protein is an essential cellular protein required for the maintenance and function of motor neurons, whose deficiency leads to spinal muscular atrophy.
F. None of above. chosen

Statements (50)

Predicate	Object
instanceOf	neuronal protein ⓘ protein ⓘ
aggregationState	forms amyloid fibrils ⓘ forms oligomers ⓘ
alsoKnownAs	NACP ⓘ PARK1 protein ⓘ non-Aβ component of Alzheimer disease amyloid ⓘ linked to: alpha-synuclein α-synuclein ⓘ
aminoAcidLength	140 amino acids ⓘ
associatedWithDisease	Parkinson's disease ⓘ dementia with Lewy bodies ⓘ multiple system atrophy ⓘ synucleinopathies ⓘ
bindsTo	phospholipid membranes ⓘ synaptic vesicles ⓘ
cellularLocation	cytosol ⓘ presynaptic terminal ⓘ synaptic vesicle membrane ⓘ
encodedBy	SNCA gene ⓘ linked to: alpha-synuclein
expressedIn	central nervous system ⓘ neurons ⓘ
foundInOrganism	Homo sapiens ⓘ
geneticVariantAssociatedWithDisease	A30P mutation ⓘ A53T mutation ⓘ E46K mutation ⓘ G51D mutation ⓘ H50Q mutation ⓘ SNCA gene duplication ⓘ SNCA gene triplication ⓘ
inclusionBodyComponentOf	Lewy bodies ⓘ glial cytoplasmic inclusions in multiple system atrophy ⓘ
misfoldingConsequence	impairment of autophagy-lysosomal pathway ⓘ impairment of proteasome function ⓘ mitochondrial dysfunction ⓘ neuronal toxicity ⓘ
molecularWeight	~14 kDa ⓘ
normalFunction	SNARE complex assembly modulation ⓘ regulation of neurotransmitter release ⓘ regulation of synaptic vesicle trafficking ⓘ
pathologicalFeature	forms Lewy bodies ⓘ forms Lewy neurites ⓘ
postTranslationalModification	nitration ⓘ phosphorylation at serine-129 ⓘ truncation ⓘ ubiquitination ⓘ
structureProperty	adopts alpha-helical structure upon membrane binding ⓘ intrinsically disordered in solution ⓘ
subcellularProcessInvolvedIn	dopamine neurotransmission ⓘ synaptic plasticity ⓘ
toxicForm	soluble oligomers ⓘ

How these facts were elicited

Referenced by (3)

Full triples — surface form annotated when it differs from this entity's canonical label.

Lewy bodies → composedOf → alpha-synuclein ⓘ

alpha-synuclein → encodedBy → SNCA gene ⓘ

linked to: alpha-synuclein

alpha-synuclein → alsoKnownAs → non-Aβ component of Alzheimer disease amyloid ⓘ