epidermal growth factor receptor family

E903677

growth factor receptor family protein family receptor tyrosine kinase family

The epidermal growth factor receptor family is a group of closely related receptor tyrosine kinases (including EGFR/HER1, HER2, HER3, and HER4) that regulate cell growth, survival, and differentiation and are key targets in cancer biology and therapy.

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All labels observed (7)

Label	Occurrences
ErbB receptor family	4
EGFR family	3
EGFR/ErbB family of receptor tyrosine kinases	1
ERBB family	1
ERBB receptor family	1
HER receptor family	1
epidermal growth factor receptor family canonical	1

How this entity was disambiguated

This entity first appeared as the object of triple T11074231 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: epidermal growth factor receptor family
Context triple: [HER2 receptor, memberOf, epidermal growth factor receptor family]

A. EGFR
EGFR (epidermal growth factor receptor) is a transmembrane receptor tyrosine kinase that regulates cell growth and survival and is frequently implicated in cancer development and progression.
B. HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
C. EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
D. ERBB3
ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
E. ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: epidermal growth factor receptor family
Target entity description: The epidermal growth factor receptor family is a group of closely related receptor tyrosine kinases (including EGFR/HER1, HER2, HER3, and HER4) that regulate cell growth, survival, and differentiation and are key targets in cancer biology and therapy.

A. EGFR
EGFR (epidermal growth factor receptor) is a transmembrane receptor tyrosine kinase that regulates cell growth and survival and is frequently implicated in cancer development and progression.
B. HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
C. EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
D. ERBB3
ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
E. ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
F. None of above. chosen

Statements (55)

Predicate	Object
instanceOf	growth factor receptor family ⓘ protein family ⓘ receptor tyrosine kinase family ⓘ
activatedBy	epidermal growth factor ⓘ neuregulins ⓘ other EGF-like ligands ⓘ transforming growth factor alpha ⓘ
activationMechanism	ligand-induced dimerization ⓘ
alternativeName	ERBB family ⓘ linked to: epidermal growth factor receptor family HER receptor family ⓘ linked to: epidermal growth factor receptor family
associatedWithDisease	breast cancer ⓘ cancer ⓘ colorectal cancer ⓘ gastric cancer ⓘ glioblastoma ⓘ head and neck squamous cell carcinoma ⓘ non-small cell lung cancer ⓘ ovarian cancer ⓘ
downstreamPathway	JAK-STAT pathway ⓘ PI3K-AKT pathway ⓘ PLCγ-PKC pathway ⓘ RAS-RAF-MEK-ERK pathway ⓘ
encodesProteinType	receptor tyrosine kinase ⓘ
evolutionarilyRelatedTo	vertebrate receptor tyrosine kinases ⓘ
formsComplexWith	heterodimers ⓘ homodimers ⓘ
hasClinicalRelevance	predictive biomarker for targeted therapy ⓘ prognostic biomarker in oncology ⓘ
hasDomain	extracellular ligand-binding domain ⓘ intracellular tyrosine kinase domain ⓘ single-pass transmembrane domain ⓘ
hasMember	EGFR ⓘ ERBB1 ⓘ linked to: EGFR ERBB2 ⓘ ERBB3 ⓘ ERBB4 ⓘ HER1 ⓘ linked to: EGFR HER2 ⓘ linked to: ERBB2 HER3 ⓘ HER4 ⓘ linked to: ERBB4
isTargetOf	antibody-drug conjugates ⓘ monoclonal antibodies ⓘ small-molecule inhibitors ⓘ tyrosine kinase inhibitors ⓘ
locatedIn	plasma membrane ⓘ
molecularAbnormality	activating mutation ⓘ gene amplification ⓘ overexpression ⓘ
participatesIn	cell differentiation regulation ⓘ cell migration regulation ⓘ cell proliferation regulation ⓘ cell survival regulation ⓘ developmental processes ⓘ signal transduction ⓘ
taxonomicScope	metazoans ⓘ

How these facts were elicited