ERBB2
E261825
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
All labels observed (10)
| Label | Occurrences |
|---|---|
| ERBB2 canonical | 4 |
| ERBB receptor family | 1 |
| ERBB2 gene | 1 |
| ERBB2 proto-oncogene | 1 |
| ERBB2 receptor tyrosine kinase | 1 |
| HER-2/neu | 1 |
| HER2 | 1 |
| Receptor tyrosine-protein kinase erbB-2 | 1 |
| human epidermal growth factor receptor 2 | 1 |
| p185HER2 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2370975 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: ERBB2 Context triple: [Herceptin, antibodyTarget, ERBB2]
-
A.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
-
B.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
-
C.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
-
D.
AACR2
AACR2 (Anglo-American Cataloguing Rules, Second Edition) is a widely used library cataloging standard that provides rules for describing and accessing library materials in online and card catalogs.
-
E.
Herceptin
Herceptin is a targeted monoclonal antibody drug used primarily to treat HER2-positive breast cancer by blocking the HER2 receptor on cancer cells.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: ERBB2 Target entity description: ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
-
A.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
-
B.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
C.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
-
D.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
-
E.
AACR2
AACR2 (Anglo-American Cataloguing Rules, Second Edition) is a widely used library cataloging standard that provides rules for describing and accessing library materials in online and card catalogs.
- F. None of above. chosen
Statements (70)
| Predicate | Object |
|---|---|
| instanceOf |
human gene
ⓘ
protein-coding gene ⓘ proto-oncogene ⓘ receptor tyrosine kinase ⓘ |
| activationMechanism | heterodimerization with other ERBB receptors ⓘ |
| associatedWithDisease |
HER2-positive breast cancer
ⓘ
bladder cancer ⓘ breast cancer ⓘ colorectal cancer ⓘ endometrial cancer ⓘ gastric adenocarcinoma ⓘ gastric cancer ⓘ gastroesophageal junction cancer ⓘ lung cancer ⓘ ovarian cancer ⓘ salivary gland carcinoma ⓘ |
| biologicalProcess |
cell differentiation
ⓘ
cell proliferation ⓘ epidermal growth factor receptor signaling pathway ⓘ phosphorylation ⓘ protein autophosphorylation ⓘ regulation of cell growth ⓘ signal transduction ⓘ |
| cellularComponent |
cell surface
ⓘ
integral component of membrane ⓘ plasma membrane ⓘ |
| clinicalBiomarkerFor | selection of anti-HER2 therapy ⓘ |
| encodes |
HER2 protein
ⓘ
linked to:
HER2 receptor
NEU proto-oncogene protein ⓘ
linked to:
HER2 receptor
Receptor tyrosine-protein kinase erbB-2 ⓘ
linked to:
ERBB2
|
| ensemblId | ENSG00000141736 ⓘ |
| entrezGeneId | 2064 ⓘ |
| formsHeterodimerWith |
EGFR (ERBB1)
ⓘ
linked to:
EGFR
ERBB3 ⓘ ERBB4 ⓘ |
| genomicAlteration |
gene amplification
ⓘ
overexpression ⓘ |
| hasDomain |
extracellular ligand-binding domain
ⓘ
intracellular tyrosine kinase domain ⓘ single-pass transmembrane domain ⓘ |
| hasSynonym |
CD340
ⓘ
ERBB2 oncogene ⓘ ERBB2 proto-oncogene ⓘ
linked to:
ERBB2
ERBB2 receptor tyrosine kinase ⓘ
linked to:
ERBB2
HER2 ⓘ
linked to:
ERBB2
NEU ⓘ p185HER2 ⓘ
linked to:
ERBB2
|
| locatedOnChromosome | chromosome 17 ⓘ |
| locatedOnChromosomeArm | 17q12 ⓘ |
| memberOf |
EGFR family
ⓘ
linked to:
epidermal growth factor receptor family
ERBB receptor family ⓘ
linked to:
epidermal growth factor receptor family
|
| molecularFunction |
ATP binding
ⓘ
protein heterodimerization activity ⓘ protein tyrosine kinase activity ⓘ |
| organism | Homo sapiens ⓘ |
| overexpressedIn |
HER2-positive breast tumors
ⓘ
some gastric tumors ⓘ |
| pathway |
ERBB signaling pathway
ⓘ
MAPK signaling pathway ⓘ PI3K-AKT signaling pathway ⓘ |
| receptorType | ligand-less co-receptor ⓘ |
| therapeuticTargetOf |
ado-trastuzumab emtansine (T-DM1)
ⓘ
fam-trastuzumab deruxtecan ⓘ lapatinib ⓘ neratinib ⓘ pertuzumab ⓘ trastuzumab ⓘ
linked to:
Herceptin
tucatinib ⓘ |
| uniprotId | P04626 ⓘ |
| usedIn | molecular subtyping of breast cancer ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: ERBB2 Description of subject: ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
Referenced by (13)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: ERBB2
linked to: ERBB2
linked to: ERBB2
linked to: ERBB2
linked to: ERBB2
linked to: ERBB2
linked to: ERBB2