CD340

E902871

CD340 is an alternative name for the human epidermal growth factor receptor 2 (HER2), a cell surface receptor tyrosine kinase often overexpressed in certain aggressive breast and gastric cancers.

All labels observed (1)

Label Occurrences
CD340 canonical 1

How this entity was disambiguated

Statements (47)

Predicate Object
instanceOf cell surface receptor ⓘ
protein ⓘ
receptor tyrosine kinase ⓘ
activatesPathway JAK-STAT signaling pathway ⓘ
MAPK/ERK signaling pathway ⓘ
PI3K-AKT signaling pathway ⓘ
alternativeNameOf ERBB2 ⓘ
HER2 ⓘ
linked to: ERBB2

human epidermal growth factor receptor 2 ⓘ
linked to: ERBB2
associatedWith aggressive breast cancer ⓘ
metastasis ⓘ
poor prognosis in breast cancer ⓘ
poor prognosis in gastric cancer ⓘ
tumor cell proliferation ⓘ
tumor cell survival ⓘ
encodes ERBB2 gene ⓘ
linked to: ERBB2
formsComplexWith EGFR (ERBB1) ⓘ
linked to: EGFR

ERBB3 ⓘ
ERBB4 ⓘ
hasBiologicalProcess cell differentiation ⓘ
cell proliferation ⓘ
epithelial cell development ⓘ
signal transduction ⓘ
hasCDDesignation CD340 ⓘ
hasCellularComponent cell surface ⓘ
plasma membrane ⓘ
hasDomain extracellular ligand-binding domain ⓘ
intracellular tyrosine kinase domain ⓘ
single-pass transmembrane domain ⓘ
hasMolecularFunction protein tyrosine kinase activity ⓘ
transmembrane receptor activity ⓘ
locatedOnChromosome human chromosome 17q12 ⓘ
memberOf EGFR/ErbB family of receptor tyrosine kinases ⓘ
ErbB receptor family ⓘ
organism Homo sapiens ⓘ
overexpressedIn HER2-positive breast cancer ⓘ
HER2-positive gastric cancer ⓘ
targetOf ado-trastuzumab emtansine ⓘ
fam-trastuzumab deruxtecan ⓘ
lapatinib ⓘ
margetuximab ⓘ
neratinib ⓘ
pertuzumab ⓘ
trastuzumab ⓘ
linked to: Herceptin

tucatinib ⓘ
usedAsBiomarkerFor HER2-positive breast cancer ⓘ
HER2-positive gastric cancer ⓘ

How these facts were elicited

Referenced by (1)

Full triples — surface form annotated when it differs from this entity's canonical label.