vascular endothelial growth factor A
E823216
Vascular endothelial growth factor A (VEGF-A) is a key signaling protein that promotes the growth of new blood vessels and increases vascular permeability, playing a central role in angiogenesis and various diseases such as cancer and eye disorders.
All labels observed (8)
| Label | Occurrences |
|---|---|
| VEGF-A | 8 |
| VEGF121 | 1 |
| VEGF165 | 1 |
| VEGF189 | 1 |
| VEGF206 | 1 |
| VEGFA gene | 1 |
| vascular endothelial growth factor A canonical | 1 |
| vascular permeability factor | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T9812303 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: vascular endothelial growth factor A Context triple: [aflibercept, targets, vascular endothelial growth factor A]
-
A.
platelet-derived growth factor
Platelet-derived growth factor is a key signaling protein that regulates cell growth, proliferation, and angiogenesis, and plays important roles in wound healing and various pathological conditions such as cancer and fibrosis.
-
B.
aflibercept
Aflibercept is an anti-VEGF biologic drug used primarily to treat neovascular (wet) age-related macular degeneration and other retinal vascular diseases.
-
C.
Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
-
D.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
-
E.
IN-2
IN-2 is the standard postal-style abbreviation used to refer to Indiana's 2nd congressional district in the U.S. House of Representatives.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: vascular endothelial growth factor A Target entity description: Vascular endothelial growth factor A (VEGF-A) is a key signaling protein that promotes the growth of new blood vessels and increases vascular permeability, playing a central role in angiogenesis and various diseases such as cancer and eye disorders.
-
A.
platelet-derived growth factor
Platelet-derived growth factor is a key signaling protein that regulates cell growth, proliferation, and angiogenesis, and plays important roles in wound healing and various pathological conditions such as cancer and fibrosis.
-
B.
aflibercept
Aflibercept is an anti-VEGF biologic drug used primarily to treat neovascular (wet) age-related macular degeneration and other retinal vascular diseases.
-
C.
Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
-
D.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
-
E.
IN-2
IN-2 is the standard postal-style abbreviation used to refer to Indiana's 2nd congressional district in the U.S. House of Representatives.
- F. None of above. chosen
Statements (70)
| Predicate | Object |
|---|---|
| instanceOf |
angiogenic factor
ⓘ
growth factor ⓘ protein ⓘ signaling molecule ⓘ |
| actsOnCellType |
endothelial cell
ⓘ
vascular smooth muscle cell (indirectly) ⓘ |
| associatedWithDisease |
age-related macular degeneration
ⓘ
cancer ⓘ diabetic retinopathy ⓘ neovascular glaucoma ⓘ pre-eclampsia (dysregulated signaling) ⓘ psoriasis ⓘ retinal vein occlusion ⓘ rheumatoid arthritis ⓘ |
| bindsTo |
VEGFR-1
ⓘ
VEGFR-2 ⓘ neuropilin-1 ⓘ neuropilin-2 ⓘ |
| discoveredBy | Napoleone Ferrara ⓘ |
| encodedBy |
VEGFA gene
ⓘ
linked to:
vascular endothelial growth factor A
|
| foundInTaxon | Homo sapiens ⓘ |
| hasAbbreviation |
VEGF-A
ⓘ
linked to:
vascular endothelial growth factor A
|
| hasAlternativeName |
VEGF
ⓘ
vascular permeability factor ⓘ
linked to:
vascular endothelial growth factor A
|
| hasBiologicalProcess |
angiogenesis
ⓘ
endothelial cell migration ⓘ endothelial cell proliferation ⓘ lymphangiogenesis (indirectly) ⓘ tumor angiogenesis ⓘ vascular permeability increase ⓘ vasculogenesis ⓘ wound healing ⓘ |
| hasCellularLocation |
extracellular space
ⓘ
secreted protein ⓘ |
| hasEffect |
increases vascular permeability
ⓘ
promotes blood vessel formation ⓘ promotes endothelial cell survival ⓘ stimulates nitric oxide production ⓘ |
| hasIsoform |
VEGF121
ⓘ
linked to:
vascular endothelial growth factor A
VEGF165 ⓘ
linked to:
vascular endothelial growth factor A
VEGF189 ⓘ
linked to:
vascular endothelial growth factor A
VEGF206 ⓘ
linked to:
vascular endothelial growth factor A
|
| hasMolecularFunction |
growth factor activity
ⓘ
receptor binding ⓘ vascular endothelial growth factor receptor binding ⓘ |
| inducedBy |
HIF-1α
ⓘ
hypoxia ⓘ inflammatory cytokines ⓘ |
| involvedInPathway |
MAPK signaling pathway
ⓘ
PI3K-Akt signaling pathway ⓘ
linked to:
PI3K-AKT signaling pathway
VEGF signaling pathway ⓘ focal adhesion pathway ⓘ |
| locatedOnChromosome | human chromosome 6 ⓘ |
| partOf | vascular endothelial growth factor family ⓘ |
| posttranslationalModification | glycosylation ⓘ |
| regulates |
angiogenic sprouting
ⓘ
endothelial cell survival ⓘ vascular permeability ⓘ |
| secretedBy |
endothelial cell
ⓘ
fibroblast ⓘ macrophage ⓘ platelet ⓘ smooth muscle cell ⓘ tumor cell ⓘ |
| targetOfDrug |
aflibercept
ⓘ
bevacizumab ⓘ
linked to:
Avastin
brolucizumab ⓘ faricimab ⓘ pegaptanib ⓘ ranibizumab ⓘ
linked to:
Lucentis
|
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: vascular endothelial growth factor A Description of subject: Vascular endothelial growth factor A (VEGF-A) is a key signaling protein that promotes the growth of new blood vessels and increases vascular permeability, playing a central role in angiogenesis and various diseases such as cancer and eye disorders.
Referenced by (15)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: vascular endothelial growth factor A
subject linked to:
vascular endothelial growth factor A
linked to: vascular endothelial growth factor A
subject linked to:
vascular endothelial growth factor A
linked to: vascular endothelial growth factor A
subject linked to:
vascular endothelial growth factor A
linked to: vascular endothelial growth factor A
subject linked to:
vascular endothelial growth factor A
linked to: vascular endothelial growth factor A
subject linked to:
vascular endothelial growth factor A
linked to: vascular endothelial growth factor A
subject linked to:
vascular endothelial growth factor A
linked to: vascular endothelial growth factor A
subject linked to:
vascular endothelial growth factor A
linked to: vascular endothelial growth factor A
linked to: vascular endothelial growth factor A
linked to: vascular endothelial growth factor A