Eylea
E579609
Eylea is a widely used injectable drug for treating retinal diseases such as wet age-related macular degeneration by inhibiting vascular endothelial growth factor (VEGF).
All labels observed (2)
| Label | Occurrences |
|---|---|
| Eylea canonical | 2 |
| Eylea (aflibercept) | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6251172 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Eylea Context triple: [Regeneron Pharmaceuticals, notableProduct, Eylea]
-
A.
Marico Eye
Marico Eye is a clear natural spring in South Africa that forms the primary headwaters of the Marico River.
-
B.
Reitia
Reitia is an ancient goddess venerated by the Veneti people of northeastern Italy, often linked to writing, healing, and protection.
-
C.
Ocilis
Ocilis is the ancient Roman-era name for the town now known as Medinaceli in Spain.
-
D.
Ochi
Ochi is a mountain located on the Greek island of Euboea, known for its rugged terrain and scenic views over the Aegean Sea.
-
E.
Rendova
Rendova is a volcanic island in the Solomon Islands' Western Province, notable for its rugged terrain, dense rainforest, and role as a World War II military base.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Eylea Target entity description: Eylea is a widely used injectable drug for treating retinal diseases such as wet age-related macular degeneration by inhibiting vascular endothelial growth factor (VEGF).
-
A.
Marico Eye
Marico Eye is a clear natural spring in South Africa that forms the primary headwaters of the Marico River.
-
B.
Reitia
Reitia is an ancient goddess venerated by the Veneti people of northeastern Italy, often linked to writing, healing, and protection.
-
C.
Ocilis
Ocilis is the ancient Roman-era name for the town now known as Medinaceli in Spain.
-
D.
Ochi
Ochi is a mountain located on the Greek island of Euboea, known for its rugged terrain and scenic views over the Aegean Sea.
-
E.
Rendova
Rendova is a volcanic island in the Solomon Islands' Western Province, notable for its rugged terrain, dense rainforest, and role as a World War II military base.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
biologic drug
ⓘ
ophthalmic drug ⓘ pharmaceutical drug ⓘ |
| hasAdverseEffect |
cataract
ⓘ
conjunctival hemorrhage ⓘ endophthalmitis ⓘ eye pain ⓘ increased intraocular pressure ⓘ intraocular inflammation ⓘ retinal detachment ⓘ thromboembolic events ⓘ vitreous detachment ⓘ |
| hasATCCode | S01LA05 ⓘ |
| hasContraindication |
active intraocular inflammation
ⓘ
hypersensitivity to aflibercept ⓘ ocular or periocular infection ⓘ |
| hasDosageForm | solution for injection ⓘ |
| hasGenericName | aflibercept ⓘ |
| hasIndication |
diabetic macular edema
ⓘ
macular edema following retinal vein occlusion ⓘ myopic choroidal neovascularization ⓘ neovascular age-related macular degeneration ⓘ wet age-related macular degeneration ⓘ |
| hasMechanismOfAction |
VEGF-A binding
ⓘ
placental growth factor binding ⓘ vascular endothelial growth factor inhibitor ⓘ |
| hasMolecularType | fusion protein ⓘ |
| hasPharmacologicalClass |
angiogenesis inhibitor
ⓘ
recombinant fusion protein ⓘ |
| hasRegulatoryApproval |
European Medicines Agency
ⓘ
U.S. Food and Drug Administration ⓘ
linked to:
Food and Drug Administration
|
| hasRouteOfAdministration |
intraocular
ⓘ
intravitreal injection ⓘ |
| hasTherapeuticArea |
ophthalmology
ⓘ
retinal vascular disease ⓘ |
| hasYearOfFirstApproval | 2011 ⓘ |
| isAdministeredBy | ophthalmologist ⓘ |
| isAdministeredFrequency |
every 4 weeks during initial phase
ⓘ
every 8 weeks during maintenance phase ⓘ |
| isManufacturedBy | Regeneron Pharmaceuticals ⓘ |
| isMarketedBy |
Bayer
ⓘ
Regeneron Pharmaceuticals ⓘ |
| isUsedFor |
prevention of vision loss
ⓘ
reduction of macular edema ⓘ treatment of retinal diseases ⓘ |
| targets |
VEGF-A
ⓘ
linked to:
vascular endothelial growth factor A
VEGF-B ⓘ placental growth factor ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Eylea Description of subject: Eylea is a widely used injectable drug for treating retinal diseases such as wet age-related macular degeneration by inhibiting vascular endothelial growth factor (VEGF).
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Eylea