Vabysmo
E822409
angiogenesis inhibitor
bispecific monoclonal antibody
brand name drug
ophthalmic drug
pharmaceutical drug
Vabysmo is the brand name for faricimab, an injectable eye medication used to treat retinal diseases such as neovascular (wet) age-related macular degeneration and diabetic macular edema.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Vabysmo canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T9807310 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Vabysmo Context triple: [faricimab, hasTradeName, Vabysmo]
-
A.
Novaggio
Novaggio is a small municipality in the canton of Ticino in southern Switzerland, known for its scenic hillside setting above Lake Lugano.
-
B.
The Youphoria
The Youphoria is a themed stage at the Tomorrowland electronic dance music festival, known for its immersive design and cutting-edge performances.
-
C.
Waldomore
Waldomore is a historic 19th-century mansion in Clarksburg, West Virginia, known for its Classical Revival architecture and its role as a cultural and archival center for the community.
-
D.
Veklury
Veklury is the brand name for remdesivir, an antiviral medication used primarily to treat COVID-19.
-
E.
Acubens
Acubens is the traditional name of Alpha Cancri, a multiple star system in the constellation Cancer.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Vabysmo Target entity description: Vabysmo is the brand name for faricimab, an injectable eye medication used to treat retinal diseases such as neovascular (wet) age-related macular degeneration and diabetic macular edema.
-
A.
Novaggio
Novaggio is a small municipality in the canton of Ticino in southern Switzerland, known for its scenic hillside setting above Lake Lugano.
-
B.
The Youphoria
The Youphoria is a themed stage at the Tomorrowland electronic dance music festival, known for its immersive design and cutting-edge performances.
-
C.
Waldomore
Waldomore is a historic 19th-century mansion in Clarksburg, West Virginia, known for its Classical Revival architecture and its role as a cultural and archival center for the community.
-
D.
Veklury
Veklury is the brand name for remdesivir, an antiviral medication used primarily to treat COVID-19.
-
E.
Acubens
Acubens is the traditional name of Alpha Cancri, a multiple star system in the constellation Cancer.
- F. None of above. chosen
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
angiogenesis inhibitor
ⓘ
bispecific monoclonal antibody ⓘ brand name drug ⓘ ophthalmic drug ⓘ pharmaceutical drug ⓘ |
| adverseEffect |
conjunctival hemorrhage
ⓘ
eye pain ⓘ increased intraocular pressure ⓘ vitreous floaters ⓘ |
| approvalYear | 2022 ⓘ |
| approvedBy |
U.S. Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
| approvedIn |
European Union
ⓘ
United States ⓘ
linked to:
United States of America
|
| belongsToClass |
anti-VEGF agents
ⓘ
anti-angiopoietin agents ⓘ |
| clinicalTrial |
LUCERNE
ⓘ
RHINE ⓘ TENAYA ⓘ YOSEMITE ⓘ |
| comparedWith | aflibercept ⓘ |
| contraindication |
active intraocular inflammation
ⓘ
ocular or periocular infection ⓘ |
| developedBy |
Genentech
ⓘ
Roche ⓘ |
| hasATCCode | S01LA07 ⓘ |
| hasDosageForm | solution for intravitreal injection ⓘ |
| hasDosingInterval |
every 4 weeks (loading phase)
ⓘ
up to every 16 weeks (maintenance phase, label-dependent) ⓘ |
| hasGenericName | faricimab ⓘ |
| hasINN | faricimab ⓘ |
| hasMechanismOfAction |
inhibits VEGF-A and Ang-2 signaling pathways
ⓘ
reduces pathological ocular neovascularization ⓘ stabilizes retinal vasculature ⓘ |
| indicationPopulation | adults ⓘ |
| legalStatus | prescription only ⓘ |
| marketedBy |
Genentech
ⓘ
Roche ⓘ |
| routeOfAdministration | intravitreal injection ⓘ |
| seriousAdverseEffect |
endophthalmitis
ⓘ
retinal detachment ⓘ |
| targets |
VEGF-A
ⓘ
linked to:
vascular endothelial growth factor A
angiopoietin-2 ⓘ vascular endothelial growth factor A ⓘ |
| therapeuticArea | ophthalmology ⓘ |
| treatsSymptom |
vision impairment due to diabetic macular edema
ⓘ
vision loss due to wet age-related macular degeneration ⓘ |
| usedFor |
diabetic macular edema
ⓘ
macular edema following retinal vein occlusion ⓘ neovascular age-related macular degeneration ⓘ retinal vein occlusion ⓘ wet age-related macular degeneration ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Vabysmo Description of subject: Vabysmo is the brand name for faricimab, an injectable eye medication used to treat retinal diseases such as neovascular (wet) age-related macular degeneration and diabetic macular edema.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.