interleukin-4
E902892
Interleukin-4 is an immune signaling cytokine that promotes B cell proliferation, differentiation, and antibody class switching, particularly toward IgE production.
All labels observed (3)
| Label | Occurrences |
|---|---|
| IL-4 | 1 |
| IL4 gene | 1 |
| interleukin-4 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074491 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: interleukin-4 Context triple: [B lymphocytes, regulatedBy, interleukin-4]
-
A.
IL-17A
IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
-
B.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
-
C.
IL18
IL18 is the ICAO aircraft type designator for the Soviet-era Ilyushin Il-18 long-range turboprop airliner.
-
D.
IN-2
IN-2 is the standard postal-style abbreviation used to refer to Indiana's 2nd congressional district in the U.S. House of Representatives.
-
E.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: interleukin-4 Target entity description: Interleukin-4 is an immune signaling cytokine that promotes B cell proliferation, differentiation, and antibody class switching, particularly toward IgE production.
-
A.
IL-17A
IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
-
B.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
-
C.
IL18
IL18 is the ICAO aircraft type designator for the Soviet-era Ilyushin Il-18 long-range turboprop airliner.
-
D.
IN-2
IN-2 is the standard postal-style abbreviation used to refer to Indiana's 2nd congressional district in the U.S. House of Representatives.
-
E.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
- F. None of above. chosen
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
cytokine
ⓘ
interleukin ⓘ signaling protein ⓘ |
| activates | STAT6 ⓘ |
| actsOnCellType |
B cell
ⓘ
T helper cell ⓘ eosinophil ⓘ macrophage ⓘ mast cell ⓘ |
| associatedWithDisease |
IgE-mediated hypersensitivity
ⓘ
allergic asthma ⓘ allergic rhinitis ⓘ atopic dermatitis ⓘ food allergy ⓘ helminth infection response ⓘ |
| bindsTo |
IL-4 receptor type I
ⓘ
linked to:
interleukin-4 receptor alpha
IL-4/IL-13 receptor type II ⓘ interleukin-4 receptor alpha chain ⓘ |
| chromosomalLocation | human chromosome 5q31.1 ⓘ |
| encodedBy |
IL4 gene
ⓘ
linked to:
interleukin-4
|
| foundInTaxon | Homo sapiens ⓘ |
| hasAlternativeName |
B cell stimulatory factor 1
ⓘ
BSF-1 ⓘ IL-4 ⓘ
linked to:
interleukin-4
|
| hasBiologicalProcess |
B cell differentiation
ⓘ
B cell proliferation ⓘ Th2 cell differentiation ⓘ allergic inflammatory response ⓘ alternative macrophage activation ⓘ antibody class switching to IgE ⓘ antibody class switching to IgG1 (in mice) ⓘ eosinophil recruitment ⓘ regulation of IgE production ⓘ regulation of Th1/Th2 balance ⓘ regulation of immune response ⓘ regulation of macrophage activation ⓘ |
| hasLength | 129 amino acids (mature human IL-4) ⓘ |
| hasMolecularFunction |
cytokine activity
ⓘ
growth factor activity ⓘ |
| hasStructure | four-helix bundle cytokine fold ⓘ |
| hasSubcellularLocation | extracellular space ⓘ |
| isSecretedProtein | true ⓘ |
| isTargetOfDrug |
dupilumab
ⓘ
linked to:
Dupixent
pascolizumab ⓘ pitrakinra ⓘ |
| secretedByCellType |
NKT cell
ⓘ
Th2 cell ⓘ basophil ⓘ eosinophil ⓘ mast cell ⓘ |
| signalsThroughPathway | JAK-STAT signaling pathway ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: interleukin-4 Description of subject: Interleukin-4 is an immune signaling cytokine that promotes B cell proliferation, differentiation, and antibody class switching, particularly toward IgE production.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: interleukin-4
linked to: interleukin-4