interleukin-4 receptor alpha
E1550587
UNEXPLORED
Interleukin-4 receptor alpha is a key immune cell surface receptor subunit that mediates signaling of the cytokines IL-4 and IL-13, playing a central role in allergic inflammation and type 2 immune responses.
All labels observed (2)
| Label | Occurrences |
|---|---|
| IL-4 receptor type I | 1 |
| interleukin-4 receptor alpha canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T22717679 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: interleukin-4 receptor alpha Context triple: [Dupixent, targetsMolecule, interleukin-4 receptor alpha]
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A.
interleukin-4
Interleukin-4 is an immune signaling cytokine that promotes B cell proliferation, differentiation, and antibody class switching, particularly toward IgE production.
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B.
IL-17RA
IL-17RA is a cell surface receptor subunit that mediates signaling for interleukin-17 family cytokines, playing a key role in inflammatory and autoimmune responses.
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C.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
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D.
Janus kinase 1
Janus kinase 1 is a tyrosine kinase enzyme involved in cytokine receptor signaling and immune regulation, making it an important therapeutic target in inflammatory and autoimmune diseases.
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E.
IL-17A
IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: interleukin-4 receptor alpha Target entity description: Interleukin-4 receptor alpha is a key immune cell surface receptor subunit that mediates signaling of the cytokines IL-4 and IL-13, playing a central role in allergic inflammation and type 2 immune responses.
-
A.
interleukin-4
Interleukin-4 is an immune signaling cytokine that promotes B cell proliferation, differentiation, and antibody class switching, particularly toward IgE production.
-
B.
IL-17RA
IL-17RA is a cell surface receptor subunit that mediates signaling for interleukin-17 family cytokines, playing a key role in inflammatory and autoimmune responses.
-
C.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
-
D.
Janus kinase 1
Janus kinase 1 is a tyrosine kinase enzyme involved in cytokine receptor signaling and immune regulation, making it an important therapeutic target in inflammatory and autoimmune diseases.
-
E.
IL-17A
IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
- F. None of above. chosen
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: interleukin-4 receptor alpha