CD22
E902890
B-cell surface antigen
cell surface glycoprotein
immunoglobulin superfamily protein
inhibitory co-receptor
CD22 is a B-cell–specific surface glycoprotein that functions as an inhibitory co-receptor modulating B cell receptor signaling and immune responses.
All labels observed (3)
How this entity was disambiguated
This entity first appeared as the object of triple T11074462 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CD22 Context triple: [B lymphocytes, express, CD22]
-
A.
CD20 protein
CD20 protein is a cell-surface antigen found primarily on B lymphocytes and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
-
B.
CD46
CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
-
C.
CD3 complex
The CD3 complex is a multi-subunit protein complex associated with the T-cell receptor that is essential for T-cell activation and signal transduction in the immune system.
-
D.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
-
E.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CD22 Target entity description: CD22 is a B-cell–specific surface glycoprotein that functions as an inhibitory co-receptor modulating B cell receptor signaling and immune responses.
-
A.
CD20 protein
CD20 protein is a cell-surface antigen found primarily on B lymphocytes and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
-
B.
CD46
CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
-
C.
CD3 complex
The CD3 complex is a multi-subunit protein complex associated with the T-cell receptor that is essential for T-cell activation and signal transduction in the immune system.
-
D.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
-
E.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
B-cell surface antigen
ⓘ
cell surface glycoprotein ⓘ immunoglobulin superfamily protein ⓘ inhibitory co-receptor ⓘ |
| alternativeName |
Siglec-2
ⓘ
linked to:
CD22
|
| associatedWithDisease |
B-cell non-Hodgkin lymphoma
ⓘ
linked to:
non-Hodgkin lymphoma
acute lymphoblastic leukemia ⓘ chronic lymphocytic leukemia ⓘ rheumatoid arthritis ⓘ systemic lupus erythematosus ⓘ |
| bindsTo |
alpha-2,6-linked sialic acid
ⓘ
sialic acid–containing ligands ⓘ |
| cellularLocation |
B cell surface
ⓘ
plasma membrane ⓘ |
| encodedBy |
CD22 gene
ⓘ
linked to:
CD22
|
| expressedOn |
B cells
ⓘ
mature B cells ⓘ peripheral B cells ⓘ |
| hasAbbreviation | ITIMs ⓘ |
| hasDomain |
cytoplasmic tail
ⓘ
extracellular domain ⓘ transmembrane domain ⓘ |
| hasFeature | immunoreceptor tyrosine-based inhibitory motifs ⓘ |
| involvedIn | endocytosis of bound antibodies or ligands ⓘ |
| ligandRecognizedOn |
glycolipids
ⓘ
glycoproteins ⓘ |
| locatedOnChromosome | human chromosome 19q13.1 ⓘ |
| memberOf |
CD antigen cluster
ⓘ
Siglec family ⓘ |
| modulates | B cell receptor signaling ⓘ |
| negativelyRegulates |
B cell activation
ⓘ
B cell receptor signaling ⓘ |
| notExpressedOn |
NK cells
ⓘ
T cells ⓘ myeloid cells ⓘ |
| orthologFoundIn |
mouse
ⓘ
rat ⓘ |
| participatesIn |
maintenance of B cell tolerance
ⓘ
regulation of immune responses ⓘ |
| phosphorylatedBy |
Src family kinases
ⓘ
Syk kinase ⓘ
linked to:
Syk tyrosine kinase
|
| recruits |
SHP-1 phosphatase
ⓘ
SHP-2 phosphatase ⓘ |
| regulates | calcium signaling in B cells ⓘ |
| targetOf |
CAR T-cell therapies
ⓘ
linked to:
Kymriah
antibody-drug conjugates ⓘ monoclonal antibodies ⓘ |
| usedAs |
diagnostic marker for B-cell malignancies
ⓘ
therapeutic target in B-cell malignancies ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CD22 Description of subject: CD22 is a B-cell–specific surface glycoprotein that functions as an inhibitory co-receptor modulating B cell receptor signaling and immune responses.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: CD22