Src family kinases
E888596
Src family kinases are a group of non-receptor tyrosine kinases that regulate key cellular processes such as proliferation, differentiation, survival, and migration, and are often implicated in cancer and immune signaling.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Src family kinases canonical | 3 |
| Src family kinases Lck and Fyn | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10837750 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Src family kinases Context triple: [Bruton tyrosine kinase, activatedBy, Src family kinases]
-
A.
ABC subfamily B
ABC subfamily B is a group of ATP-binding cassette (ABC) transporters that typically function as membrane proteins involved in the translocation of various molecules across cellular membranes and often contribute to multidrug resistance.
-
B.
PKC
PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
-
C.
PKC
PKC is the IATA airport code for Petropavlovsk-Kamchatsky Airport, a major air gateway to Russia’s Kamchatka Peninsula.
-
D.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
E.
SYK
SYK is the stock ticker symbol for Stryker Corporation, a major U.S.-based medical technology company specializing in surgical equipment, orthopedics, and related healthcare products.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Src family kinases Target entity description: Src family kinases are a group of non-receptor tyrosine kinases that regulate key cellular processes such as proliferation, differentiation, survival, and migration, and are often implicated in cancer and immune signaling.
-
A.
ABC subfamily B
ABC subfamily B is a group of ATP-binding cassette (ABC) transporters that typically function as membrane proteins involved in the translocation of various molecules across cellular membranes and often contribute to multidrug resistance.
-
B.
PKC
PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
-
C.
PKC
PKC is the IATA airport code for Petropavlovsk-Kamchatsky Airport, a major air gateway to Russia’s Kamchatka Peninsula.
-
D.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
E.
SYK
SYK is the stock ticker symbol for Stryker Corporation, a major U.S.-based medical technology company specializing in surgical equipment, orthopedics, and related healthcare products.
- F. None of above. chosen
Statements (87)
| Predicate | Object |
|---|---|
| instanceOf |
non-receptor tyrosine kinase family
ⓘ
protein family ⓘ |
| associatedWith |
autoimmune diseases
ⓘ
bone resorption ⓘ cancer ⓘ inflammatory diseases ⓘ leukemia ⓘ lymphoma ⓘ osteoporosis ⓘ solid tumors ⓘ |
| biologicalProcess |
B cell receptor signaling pathway
ⓘ
T cell receptor signaling pathway ⓘ cell adhesion ⓘ cell differentiation ⓘ cell migration ⓘ cell proliferation ⓘ cell survival ⓘ cytoskeletal organization ⓘ growth factor receptor signaling pathway ⓘ immune receptor signaling pathway ⓘ integrin-mediated signaling pathway ⓘ signal transduction ⓘ |
| catalyzes | protein tyrosine phosphorylation ⓘ |
| cellularLocation |
cytoplasm
ⓘ
perinuclear region ⓘ plasma membrane ⓘ |
| discoveredIn | context of Rous sarcoma virus research ⓘ |
| evolutionarilyConservedIn |
metazoans
ⓘ
vertebrates ⓘ |
| hasConservedMotif |
DFG motif in activation loop
ⓘ
HRD motif in catalytic loop ⓘ |
| hasConservedResidue |
C-terminal regulatory tyrosine residue
ⓘ
catalytic lysine in kinase domain ⓘ |
| hasDomain |
C-terminal regulatory tail
ⓘ
N-terminal myristoylation motif ⓘ SH2 domain ⓘ SH3 domain ⓘ protein tyrosine kinase domain ⓘ unique N-terminal region ⓘ |
| hasMember |
BLK
ⓘ
BRK ⓘ CHK ⓘ CSK ⓘ FGR ⓘ FRK ⓘ FYN ⓘ HCK ⓘ LCK ⓘ LYN ⓘ MATK ⓘ PTK6 ⓘ SRC ⓘ SRMS ⓘ YES1 ⓘ YRK ⓘ |
| inhibitedBy |
PP2 (experimental inhibitor)
ⓘ
SU6656 (experimental inhibitor) ⓘ bosutinib ⓘ dasatinib ⓘ
linked to:
Sprycel
ponatinib ⓘ saracatinib ⓘ |
| molecularFunction |
ATP binding
ⓘ
non-receptor protein tyrosine kinase activity ⓘ |
| nameDerivedFrom |
Rous sarcoma virus Src oncogene
ⓘ
linked to:
RNA tumor viruses
|
| pathwayInvolvement |
EGFR signaling pathway
ⓘ
PDGFR signaling pathway ⓘ VEGFR signaling pathway ⓘ adaptive immune signaling pathways ⓘ focal adhesion signaling pathway ⓘ innate immune signaling pathways ⓘ oncogenic signaling pathways ⓘ platelet activation pathways ⓘ |
| positivelyRegulates |
MAPK signaling pathway
ⓘ
PI3K-AKT signaling pathway ⓘ RAS signaling pathway ⓘ |
| postTranslationalModification |
N-terminal myristoylation
ⓘ
N-terminal palmitoylation (subset of members) ⓘ serine/threonine phosphorylation ⓘ tyrosine phosphorylation ⓘ |
| regulatedBy |
C-terminal Src kinase
ⓘ
CSK ⓘ SH2 domain intramolecular interaction ⓘ SH3 domain intramolecular interaction ⓘ binding of activated receptors ⓘ phosphorylation of C-terminal tyrosine ⓘ protein tyrosine phosphatases ⓘ |
| subClassOf | tyrosine kinase family ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Src family kinases Description of subject: Src family kinases are a group of non-receptor tyrosine kinases that regulate key cellular processes such as proliferation, differentiation, survival, and migration, and are often implicated in cancer and immune signaling.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Src family kinases