microscopic polyangiitis
E902884
Microscopic polyangiitis is a rare autoimmune small-vessel vasculitis that causes inflammation and damage in organs such as the kidneys, lungs, and nerves, often associated with anti-neutrophil cytoplasmic antibodies (ANCA).
All labels observed (1)
| Label | Occurrences |
|---|---|
| microscopic polyangiitis canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074432 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: microscopic polyangiitis Context triple: [CD20 protein, therapeuticArea, microscopic polyangiitis]
-
A.
Wegener's granulomatosis
Wegener's granulomatosis, now more commonly called granulomatosis with polyangiitis, is a rare autoimmune disease characterized by inflammation of blood vessels that can damage organs such as the lungs, kidneys, and upper respiratory tract.
-
B.
PR3-ANCA
PR3-ANCA is an autoantibody directed against proteinase 3 that is strongly associated with granulomatosis with polyangiitis (formerly Wegener's granulomatosis) and used as a key diagnostic marker for this vasculitic disease.
-
C.
Behçet's disease
Behçet's disease is a rare, chronic inflammatory disorder characterized by recurrent mouth and genital ulcers, eye inflammation, and systemic vasculitis affecting multiple organ systems.
-
D.
erythema nodosum
Erythema nodosum is an inflammatory condition characterized by tender red nodules, usually on the shins, often associated with systemic diseases such as infections, autoimmune disorders, and inflammatory bowel disease.
-
E.
Behçet
Behçet is a Turkish surname most notably associated with dermatologist Hulusi Behçet, after whom Behçet's disease is named.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: microscopic polyangiitis Target entity description: Microscopic polyangiitis is a rare autoimmune small-vessel vasculitis that causes inflammation and damage in organs such as the kidneys, lungs, and nerves, often associated with anti-neutrophil cytoplasmic antibodies (ANCA).
-
A.
Wegener's granulomatosis
Wegener's granulomatosis, now more commonly called granulomatosis with polyangiitis, is a rare autoimmune disease characterized by inflammation of blood vessels that can damage organs such as the lungs, kidneys, and upper respiratory tract.
-
B.
PR3-ANCA
PR3-ANCA is an autoantibody directed against proteinase 3 that is strongly associated with granulomatosis with polyangiitis (formerly Wegener's granulomatosis) and used as a key diagnostic marker for this vasculitic disease.
-
C.
Behçet's disease
Behçet's disease is a rare, chronic inflammatory disorder characterized by recurrent mouth and genital ulcers, eye inflammation, and systemic vasculitis affecting multiple organ systems.
-
D.
erythema nodosum
Erythema nodosum is an inflammatory condition characterized by tender red nodules, usually on the shins, often associated with systemic diseases such as infections, autoimmune disorders, and inflammatory bowel disease.
-
E.
Behçet
Behçet is a Turkish surname most notably associated with dermatologist Hulusi Behçet, after whom Behçet's disease is named.
- F. None of above. chosen
Statements (60)
| Predicate | Object |
|---|---|
| instanceOf |
ANCA-associated vasculitis
ⓘ
autoimmune disease ⓘ small-vessel vasculitis ⓘ |
| affects |
arterioles
ⓘ
capillaries ⓘ small blood vessels ⓘ venules ⓘ |
| associatedWith |
MPO-ANCA
ⓘ
anti-neutrophil cytoplasmic antibodies ⓘ p-ANCA ⓘ |
| bodySystemAffected |
kidneys
ⓘ
lungs ⓘ peripheral nervous system ⓘ
linked to:
Peripheral nervous system
skin ⓘ |
| differentialDiagnosis |
Henoch–Schönlein purpura
ⓘ
linked to:
IgA vasculitis
cryoglobulinemic vasculitis ⓘ eosinophilic granulomatosis with polyangiitis ⓘ granulomatosis with polyangiitis ⓘ
linked to:
Wegener's granulomatosis
immune complex vasculitis ⓘ |
| hasCause | autoimmune reaction ⓘ |
| hasComplication |
chronic kidney disease
ⓘ
end-stage renal disease ⓘ pulmonary hemorrhage ⓘ rapidly progressive glomerulonephritis ⓘ respiratory failure ⓘ |
| hasCourse |
chronic relapsing-remitting course
ⓘ
potentially life-threatening ⓘ |
| hasDiagnosticTest |
ANCA testing
ⓘ
chest imaging ⓘ kidney biopsy ⓘ nerve or skin biopsy ⓘ urinalysis ⓘ |
| hasEpidemiology |
affects both sexes
ⓘ
affects middle-aged and older adults ⓘ |
| hasPathology |
crescentic glomerulonephritis
ⓘ
necrotizing vasculitis ⓘ pauci-immune glomerulonephritis ⓘ |
| hasSymptom |
arthralgia
ⓘ
cough ⓘ dyspnea ⓘ fatigue ⓘ fever ⓘ hematuria ⓘ hemoptysis ⓘ mononeuritis multiplex ⓘ myalgia ⓘ palpable purpura ⓘ peripheral neuropathy ⓘ proteinuria ⓘ skin purpura ⓘ weight loss ⓘ |
| medicalCondition | rare disease ⓘ |
| treatedWith |
azathioprine
ⓘ
cyclophosphamide ⓘ glucocorticoids ⓘ methotrexate ⓘ mycophenolate mofetil ⓘ plasmapheresis ⓘ rituximab ⓘ
linked to:
Rituxan
|
| typicallyLacks | granulomatous inflammation ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: microscopic polyangiitis Description of subject: Microscopic polyangiitis is a rare autoimmune small-vessel vasculitis that causes inflammation and damage in organs such as the kidneys, lungs, and nerves, often associated with anti-neutrophil cytoplasmic antibodies (ANCA).
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.