GNAI3 gene (for Gαi3 in humans)

E876997

protein-coding gene

The GNAI3 gene encodes the Gαi3 alpha subunit of heterotrimeric G proteins in humans, a key regulator of inhibitory G protein–coupled receptor signaling pathways that modulate intracellular second messengers such as cAMP.

Try in SPARQL Jump to: Surface forms Disambiguation Statements Elicitation Referenced by

All labels observed (4)

Label	Occurrences
G protein subunit alpha i3	1
GNAI-3	1
GNAI3 gene (for Gαi3 in humans) canonical	1
Gαi3	1

How this entity was disambiguated

This entity first appeared as the object of triple T10610035 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: GNAI3 gene (for Gαi3 in humans)
Context triple: [Gi protein, encodedBy, GNAI3 gene (for Gαi3 in humans)]

A. GNAI2 gene (for Gαi2 in humans)
The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
B. Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
C. GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
D. ABCG2 gene
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
E. Gi-coupled GPCR
A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: GNAI3 gene (for Gαi3 in humans)
Target entity description: The GNAI3 gene encodes the Gαi3 alpha subunit of heterotrimeric G proteins in humans, a key regulator of inhibitory G protein–coupled receptor signaling pathways that modulate intracellular second messengers such as cAMP.

A. GNAI2 gene (for Gαi2 in humans)
The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.
B. Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
C. GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
D. ABCG2 gene
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
E. Gi-coupled GPCR
A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
F. None of above. chosen

Statements (48)

Predicate	Object
instanceOf	protein-coding gene ⓘ
associatedWith	auriculocondylar syndrome ⓘ craniofacial developmental disorders ⓘ
belongsToFamily	G alpha i/o family ⓘ linked to: Gi protein
belongsToPathway	Gi-coupled GPCR signaling pathway ⓘ inhibition of adenylate cyclase pathway ⓘ
encodes	G protein subunit alpha i3 ⓘ linked to: GNAI3 gene (for Gαi3 in humans) Gαi3 ⓘ linked to: GNAI3 gene (for Gαi3 in humans)
expressedIn	human brain ⓘ human heart ⓘ human immune cells ⓘ human kidney ⓘ
hasAlias	GNAI-3 ⓘ linked to: GNAI3 gene (for Gαi3 in humans) Gi alpha-3 ⓘ Gαi3 ⓘ
hasGeneID	NCBI Gene:2773 ⓘ
hasGeneProduct	UniProt:P08754 ⓘ
hasHGNCID	HGNC:4395 ⓘ
hasMolecularFunction	GTP binding ⓘ GTPase activity ⓘ signal transducer activity ⓘ
hasOrtholog	mouse Gnai3 ⓘ rat Gnai3 ⓘ
inhibits	adenylate cyclase ⓘ
interactsWith	GNB1 ⓘ GNG2 ⓘ RGS proteins ⓘ adenylate cyclase isoforms ⓘ
involvedIn	GTP-dependent protein signaling ⓘ chemokine receptor signaling pathway ⓘ regulation of intracellular cAMP levels ⓘ signal transduction ⓘ
locatedIn	Homo sapiens ⓘ
locatedOnChromosome	human chromosome 1 ⓘ
negativelyRegulates	cAMP biosynthetic process ⓘ
participatesIn	G protein–coupled receptor signaling pathway ⓘ heterotrimeric G protein signaling pathway ⓘ inhibitory G protein–coupled receptor signaling ⓘ
positivelyRegulates	MAPK cascade via GPCR signaling ⓘ
productInstanceOf	G protein alpha subunit ⓘ Gi alpha subunit ⓘ heterotrimeric G protein alpha subunit ⓘ
regulatedBy	G protein–coupled receptors ⓘ
regulates	adenylate cyclase activity ⓘ cyclic AMP signaling ⓘ
subcellularLocation	cytoplasm ⓘ inner leaflet of plasma membrane ⓘ plasma membrane ⓘ