HIV-1

E719039

HIV-1 is the primary virus responsible for the global HIV/AIDS pandemic, characterized by its rapid mutation and attack on the human immune system’s CD4+ T cells.

All labels observed (4)

Label Occurrences
HIV 10
HIV-1 canonical 1
HIV-1 reverse transcriptase 1

How this entity was disambiguated

Statements (97)

Predicate Object
instanceOf RNA virus ⓘ
human pathogen ⓘ
lentivirus ⓘ
retrovirus ⓘ
biosafetyLevel BSL-3 pathogen ⓘ
causes AIDS ⓘ
HIV infection ⓘ
diagnosedBy HIV RNA PCR tests ⓘ
HIV antibody tests ⓘ
HIV antigen tests ⓘ
drugTarget entry receptors ⓘ
integrase ⓘ
protease ⓘ
reverse transcriptase ⓘ
encodesProtein Env glycoprotein gp160 ⓘ
Gag polyprotein ⓘ
Nef protein ⓘ
Pol polyprotein ⓘ
Rev protein ⓘ
Tat protein ⓘ
Vif protein ⓘ
Vpr protein ⓘ
Vpu protein ⓘ
gp120 ⓘ
gp41 ⓘ
integrase ⓘ
protease ⓘ
reverse transcriptase ⓘ
entryMechanism fusion with host cell membrane ⓘ
family Retroviridae ⓘ
firstIsolatedBy Luc Montagnier’s team at the Pasteur Institute ⓘ
linked to: Luc Montagnier
firstRecognized early 1980s ⓘ
genomeLength approximately 9.7 kilobases ⓘ
genomeSegmentation non-segmented ⓘ
genomeType single-stranded positive-sense RNA ⓘ
genus Lentivirus ⓘ
groupMHasSubtype A ⓘ
B ⓘ
C ⓘ
D ⓘ
F ⓘ
G ⓘ
H ⓘ
J ⓘ
K ⓘ
hasEnzymeActivity integrase activity ⓘ
protease activity ⓘ
reverse transcriptase activity ⓘ
hasGene env ⓘ
gag ⓘ
nef ⓘ
pol ⓘ
rev ⓘ
tat ⓘ
vif ⓘ
vpr ⓘ
vpu ⓘ
hasGroup M ⓘ
N ⓘ
O ⓘ
P ⓘ
hasProperty causes progressive immune deficiency ⓘ
establishes latent infection ⓘ
high genetic variability ⓘ
high mutation rate ⓘ
hasStructure conical capsid ⓘ
enveloped virion ⓘ
host Homo sapiens ⓘ
immuneSystemEffect depletion of CD4+ T cells ⓘ
impairment of cell-mediated immunity ⓘ
integrationTarget host genome DNA ⓘ
majorPandemicGroup group M ⓘ
notTransmittedBy airborne route ⓘ
casual contact ⓘ
insect bites ⓘ
order Ortervirales ⓘ
parentTaxon Human immunodeficiency virus ⓘ
linked to: HIV-1

Lentivirus ⓘ
linked to: Pararnavirae

Orthoretrovirinae ⓘ
linked to: Retroviridae

Retroviridae ⓘ
primaryCauseOf global HIV/AIDS pandemic ⓘ
replicationSite host cell cytoplasm ⓘ
host cell nucleus ⓘ
subtypeOf HIV ⓘ
linked to: HIV-1
targetsCellType CD4+ T cell ⓘ
dendritic cell ⓘ
macrophage ⓘ
taxonRank species ⓘ
transmissionRoute blood exposure ⓘ
mother-to-child transmission ⓘ
sexual contact ⓘ
sharing of contaminated needles ⓘ
treatment antiretroviral therapy ⓘ
usesCoreceptor CCR5 ⓘ
CXCR4 ⓘ
usesReceptor CD4 ⓘ
zoonoticOrigin chimpanzee SIVcpz ⓘ

How these facts were elicited

Referenced by (13)

Full triples — surface form annotated when it differs from this entity's canonical label.

CD4+ T cells → areTargetedBy → HIV ⓘ
linked to: HIV-1
human adenovirus serotype 26 → usedInVaccineAgainst → HIV ⓘ
linked to: HIV-1
Thomas David Morrison → testedPositiveFor → HIV ⓘ
linked to: HIV-1
Truvada → targets → HIV-1 reverse transcriptase ⓘ
linked to: HIV-1
Vir Biotechnology → hasResearchArea → HIV ⓘ
linked to: HIV-1
A Planet of Viruses → hasSubject → HIV ⓘ
linked to: HIV-1
HIV-1 → parentTaxon → Human immunodeficiency virus ⓘ
linked to: HIV-1
HIV-1 → subtypeOf → HIV ⓘ
linked to: HIV-1
OHAIDP → topic → HIV ⓘ
linked to: HIV-1
World AIDS Day → focusesOn → HIV ⓘ
subject linked to: WAD
linked to: HIV-1