Truvada

E409694

HIV medication antiretroviral medication brand-name drug fixed-dose combination drug

Truvada is a prescription antiretroviral medication widely used both to treat HIV infection and as pre-exposure prophylaxis (PrEP) to help prevent HIV in high-risk individuals.

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All labels observed (2)

Label	Occurrences
Truvada canonical	1
emtricitabine and tenofovir disoproxil fumarate	1

How this entity was disambiguated

This entity first appeared as the object of triple T4050927 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: Truvada
Context triple: [Gilead Sciences, product, Truvada]

A. AZT
AZT is the standard time zone used in Azerbaijan, typically four hours ahead of Coordinated Universal Time (UTC+4).
B. Waylivra
Waylivra is a prescription antisense oligonucleotide therapy used to treat familial chylomicronemia syndrome (FCS) by reducing triglyceride levels in the blood.
C. Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
D. Darzalex
Darzalex is a monoclonal antibody drug (daratumumab) used primarily in the treatment of multiple myeloma.
E. Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: Truvada
Target entity description: Truvada is a prescription antiretroviral medication widely used both to treat HIV infection and as pre-exposure prophylaxis (PrEP) to help prevent HIV in high-risk individuals.

A. AZT
AZT is the standard time zone used in Azerbaijan, typically four hours ahead of Coordinated Universal Time (UTC+4).
B. Waylivra
Waylivra is a prescription antisense oligonucleotide therapy used to treat familial chylomicronemia syndrome (FCS) by reducing triglyceride levels in the blood.
C. Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
D. Darzalex
Darzalex is a monoclonal antibody drug (daratumumab) used primarily in the treatment of multiple myeloma.
E. Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
F. None of above. chosen

Statements (48)

Predicate	Object
instanceOf	HIV medication ⓘ antiretroviral medication ⓘ brand-name drug ⓘ fixed-dose combination drug ⓘ
approvedBy	U.S. Food and Drug Administration ⓘ linked to: Food and Drug Administration
ATCCode	J05AR02 ⓘ
boxedWarning	risk of acute exacerbations of hepatitis B after discontinuation ⓘ risk of lactic acidosis and severe hepatomegaly with steatosis ⓘ
commonSideEffect	diarrhea ⓘ headache ⓘ nausea ⓘ
containsDoseStrength	emtricitabine 200 mg ⓘ tenofovir disoproxil fumarate 300 mg ⓘ
contraindication	severe renal impairment ⓘ
developer	Gilead Sciences ⓘ linked to: Gilead Sciences (board member)
dosageForm	tablet ⓘ
drugClass	nucleoside reverse transcriptase inhibitor ⓘ nucleotide reverse transcriptase inhibitor ⓘ
FDAApprovalIndication	pre-exposure prophylaxis to reduce the risk of sexually acquired HIV-1 infection ⓘ treatment of HIV-1 infection in combination with other antiretrovirals ⓘ
FDAApprovalYear	2004 ⓘ
hasActiveIngredient	emtricitabine ⓘ tenofovir disoproxil fumarate ⓘ
hasGenericName	emtricitabine and tenofovir disoproxil fumarate ⓘ linked to: Truvada
hasPatentHolder	Gilead Sciences ⓘ linked to: Gilead Sciences (board member)
indication	post-exposure prophylaxis for HIV (off-label in some settings) ⓘ pre-exposure prophylaxis for HIV-1 (PrEP) ⓘ treatment of HIV-1 infection ⓘ
isGenericAvailable	true ⓘ
isNotEffectiveAgainst	established HIV infection when used alone ⓘ
isOnWHOEML	yes ⓘ
isUsedWith	other antiretroviral agents ⓘ
legalStatusEU	prescription-only ⓘ
legalStatusUS	prescription-only ⓘ
marketingAuthorizationHolder	Gilead Sciences ⓘ linked to: Gilead Sciences (board member)
pregnancyCategoryUS	B (historical classification) ⓘ
prevents	sexual transmission of HIV-1 when used as PrEP with adherence ⓘ
requiresCombinationForTreatment	yes ⓘ
requiresMonitoring	HIV status before and during PrEP ⓘ renal function ⓘ
routeOfAdministration	oral ⓘ
seriousSideEffect	decreased bone mineral density ⓘ renal impairment ⓘ
takenFrequency	once daily ⓘ
targets	HIV-1 reverse transcriptase ⓘ linked to: HIV-1
usedForPopulation	adolescents at high risk of HIV infection (meeting weight and other criteria) ⓘ adults at high risk of HIV infection ⓘ
usedInProgram	HIV prevention programs worldwide ⓘ