human adenovirus serotype 26 (Ad26)

E241391

adenovirus serotype non-replicating viral vector vaccine platform viral vector

Human adenovirus serotype 26 (Ad26) is a non-replicating viral vector commonly used in vaccine development to deliver genetic material encoding target antigens and stimulate an immune response.

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All labels observed (3)

Label	Occurrences
Ad26	1
HAdV-26	1
human adenovirus serotype 26 (Ad26) canonical	1

How this entity was disambiguated

This entity first appeared as the object of triple T2190751 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: human adenovirus serotype 26 (Ad26)
Context triple: [Janssen COVID-19 Vaccine, usesViralVector, human adenovirus serotype 26 (Ad26)]

A. rVSV-ZEBOV
rVSV-ZEBOV is an experimental recombinant vesicular stomatitis virus-based vaccine developed to protect humans against infection by the Zaire strain of the Ebola virus.
B. Immunix
Immunix was a security-focused software company known for developing Linux security technologies, including the precursor to the AppArmor mandatory access control system.
C. Leqembi
Leqembi is an Alzheimer’s disease drug (lecanemab) that targets amyloid-beta plaques to slow cognitive decline in early-stage patients.
D. The O2 complex
The O2 complex is a large entertainment district in London featuring the O2 Arena, cinemas, restaurants, bars, and various leisure and retail facilities housed under the iconic dome structure.
E. Lextran
Lextran is the public bus transit system serving Lexington and surrounding areas in Fayette County, Kentucky.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: human adenovirus serotype 26 (Ad26)
Target entity description: Human adenovirus serotype 26 (Ad26) is a non-replicating viral vector commonly used in vaccine development to deliver genetic material encoding target antigens and stimulate an immune response.

A. rVSV-ZEBOV
rVSV-ZEBOV is an experimental recombinant vesicular stomatitis virus-based vaccine developed to protect humans against infection by the Zaire strain of the Ebola virus.
B. Immunix
Immunix was a security-focused software company known for developing Linux security technologies, including the precursor to the AppArmor mandatory access control system.
C. Leqembi
Leqembi is an Alzheimer’s disease drug (lecanemab) that targets amyloid-beta plaques to slow cognitive decline in early-stage patients.
D. The O2 complex
The O2 complex is a large entertainment district in London featuring the O2 Arena, cinemas, restaurants, bars, and various leisure and retail facilities housed under the iconic dome structure.
E. Lextran
Lextran is the public bus transit system serving Lexington and surrounding areas in Fayette County, Kentucky.
F. None of above. chosen

Statements (48)

Predicate	Object
instanceOf	adenovirus serotype ⓘ non-replicating viral vector ⓘ vaccine platform ⓘ viral vector ⓘ
administrationRegimen	single-dose regimen in some vaccines ⓘ
biosafetyLevel	handled under BSL-2 in laboratory settings ⓘ
boostCompatibility	can be combined with other vector platforms ⓘ
canBeUsedIn	prime-boost vaccination regimens ⓘ
deliveryMethod	intramuscular injection in vaccines ⓘ
developerOfVectorPlatform	Janssen Vaccines ⓘ linked to: Janssen Pharmaceuticals
encodesInCOVID19Vaccine	SARS-CoV-2 spike glycoprotein ⓘ
encodesInVaccines	pathogen-specific antigens ⓘ
family	Adenoviridae ⓘ
genomeStructure	linear DNA genome ⓘ
genomeType	double-stranded DNA virus ⓘ
genus	Mastadenovirus ⓘ
hasSynonym	Ad26 ⓘ linked to: human adenovirus serotype 26 (Ad26) HAdV-26 ⓘ linked to: human adenovirus serotype 26 (Ad26)
host	Homo sapiens ⓘ
immunogenicityProfile	induces neutralizing antibodies to encoded antigen ⓘ induces strong T-cell responses ⓘ
induces	cellular immune response ⓘ humoral immune response ⓘ
isReplicationCompetentInVaccineForm	no ⓘ
isReplicationDefectiveInVaccineForm	yes ⓘ
platformType	viral vector vaccine platform ⓘ
preExistingImmunityInHumans	lower than common adenovirus serotype 5 ⓘ
replicationDefectMechanism	E1 gene deletion ⓘ
safetyFeature	cannot cause disease related to target pathogen ⓘ non-replicating in vaccinated individuals ⓘ
targetCellEntryReceptor	CD46 ⓘ
taxonomicGroup	Human mastadenovirus D ⓘ
tropism	human cells expressing CD46 ⓘ
usedFor	delivery of genetic material encoding antigens ⓘ vaccine development ⓘ
usedInProduct	Ad26.COV2.S ⓘ Ad26.ZEBOV ⓘ Janssen COVID-19 Vaccine ⓘ Zabdeno ⓘ
usedInVaccineAgainst	Ebola virus ⓘ linked to: Ebolavirus HIV ⓘ linked to: HIV-1 SARS-CoV-2 ⓘ Zika virus ⓘ filoviruses ⓘ respiratory syncytial virus ⓘ linked to: respiratory syncytial virus (RSV)
vectorBackboneUsedBy	Janssen COVID-19 Vaccine ⓘ Johnson & Johnson COVID-19 vaccine ⓘ linked to: Janssen COVID-19 Vaccine
vectorType	non-replicating adenoviral vector ⓘ