PR3-ANCA
E465982
PR3-ANCA is an autoantibody directed against proteinase 3 that is strongly associated with granulomatosis with polyangiitis (formerly Wegener's granulomatosis) and used as a key diagnostic marker for this vasculitic disease.
All labels observed (1)
| Label | Occurrences |
|---|---|
| PR3-ANCA canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4771165 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: PR3-ANCA Context triple: [Wegener's granulomatosis, hasBiomarker, PR3-ANCA]
-
A.
Wegener's granulomatosis
Wegener's granulomatosis, now more commonly called granulomatosis with polyangiitis, is a rare autoimmune disease characterized by inflammation of blood vessels that can damage organs such as the lungs, kidneys, and upper respiratory tract.
-
B.
SLE
SLE is a commuter rail service operating along the Connecticut shoreline, connecting towns between New London and New Haven.
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C.
SLE
SLE is a mid-level trim package for GMC vehicles that typically adds upgraded comfort, convenience, and appearance features over the base model.
-
D.
SLE
SLE is the three-letter ISO 3166-1 alpha-3 country code assigned to Sierra Leone.
-
E.
JIA
JIA is the professional organization representing architects in Japan, responsible for promoting architectural standards, education, and cultural exchange in the field.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: PR3-ANCA Target entity description: PR3-ANCA is an autoantibody directed against proteinase 3 that is strongly associated with granulomatosis with polyangiitis (formerly Wegener's granulomatosis) and used as a key diagnostic marker for this vasculitic disease.
-
A.
Wegener's granulomatosis
Wegener's granulomatosis, now more commonly called granulomatosis with polyangiitis, is a rare autoimmune disease characterized by inflammation of blood vessels that can damage organs such as the lungs, kidneys, and upper respiratory tract.
-
B.
SLE
SLE is a mid-level trim package for GMC vehicles that typically adds upgraded comfort, convenience, and appearance features over the base model.
-
C.
SLE
SLE is the three-letter ISO 3166-1 alpha-3 country code assigned to Sierra Leone.
-
D.
SLE
SLE is a commuter rail service operating along the Connecticut shoreline, connecting towns between New London and New Haven.
-
E.
JIA
JIA is the professional organization representing architects in Japan, responsible for promoting architectural standards, education, and cultural exchange in the field.
- F. None of above. chosen
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf | autoantibody ⓘ |
| abbreviationOf | proteinase 3 antineutrophil cytoplasmic antibody ⓘ |
| antibodyClass | IgG ⓘ |
| antigenLocation |
azurophilic granules of neutrophils
ⓘ
monocyte lysosomes ⓘ |
| antigenType | serine protease ⓘ |
| associatedWithAntigen | PR3 ⓘ |
| associatedWithClinicalFeature |
necrotizing granulomatous inflammation
ⓘ
necrotizing vasculitis of small to medium vessels ⓘ |
| associatedWithDisease |
ANCA-associated vasculitis
ⓘ
Wegener's granulomatosis ⓘ granulomatosis with polyangiitis ⓘ
linked to:
Wegener's granulomatosis
systemic small-vessel vasculitis ⓘ |
| associatedWithOrganInvolvement |
kidneys
ⓘ
lower respiratory tract ⓘ upper respiratory tract ⓘ |
| associatedWithPrognosis | relapse risk in ANCA-associated vasculitis ⓘ |
| belongsToField |
clinical immunology
ⓘ
nephrology ⓘ rheumatology ⓘ |
| biologicalRole | pathogenic autoantibody in some models of vasculitis ⓘ |
| clinicalRelevance |
high specificity for granulomatosis with polyangiitis
ⓘ
supports diagnosis in compatible clinical context ⓘ |
| contrastedWith | MPO-ANCA ⓘ |
| detectedBy |
enzyme-linked immunosorbent assay
ⓘ
indirect immunofluorescence ⓘ |
| fullName | proteinase 3 antineutrophil cytoplasmic antibody ⓘ |
| hasAlternativeName | c-ANCA to proteinase 3 ⓘ |
| hasHigherPrevalenceIn | granulomatosis with polyangiitis compared to microscopic polyangiitis ⓘ |
| hasImmunofluorescencePattern |
c-ANCA
ⓘ
cytoplasmic ANCA pattern ⓘ |
| isSubtypeOf |
ANCA
ⓘ
antineutrophil cytoplasmic antibody ⓘ |
| laboratoryTestType | autoantibody test ⓘ |
| measuredIn |
plasma
ⓘ
serum ⓘ |
| standardizedIn | international ANCA testing guidelines ⓘ |
| targetAntigen | proteinase 3 ⓘ |
| targetLocation | neutrophil cytoplasmic granules ⓘ |
| usedAs |
diagnostic marker
ⓘ
serologic marker ⓘ |
| usedFor |
disease classification in vasculitis
ⓘ
monitoring disease activity in some patients ⓘ |
| usedIn | classification criteria for ANCA-associated vasculitis ⓘ |
| usedInDiagnosisOf |
ANCA-associated vasculitis
ⓘ
granulomatosis with polyangiitis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: PR3-ANCA Description of subject: PR3-ANCA is an autoantibody directed against proteinase 3 that is strongly associated with granulomatosis with polyangiitis (formerly Wegener's granulomatosis) and used as a key diagnostic marker for this vasculitic disease.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.