A Genetic Switch: Phage Lambda and Higher Organisms
E426564
"A Genetic Switch: Phage Lambda and Higher Organisms" is a seminal molecular biology book that explains how gene regulation in bacteriophage lambda illuminates fundamental mechanisms of genetic control in more complex organisms.
All labels observed (2)
| Label | Occurrences |
|---|---|
| A Genetic Switch: Phage Lambda and Higher Organisms canonical | 3 |
| A Genetic Switch | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4274180 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: A Genetic Switch: Phage Lambda and Higher Organisms Context triple: [Mark Ptashne, notableWork, A Genetic Switch: Phage Lambda and Higher Organisms]
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A.
From Bacteria to Bach and Back
From Bacteria to Bach and Back is a philosophical work by Daniel Dennett that explores how mind, consciousness, and culture could have evolved from simple biological beginnings through natural selection and cultural evolution.
-
B.
The Language of Life
The Language of Life is a popular science book by geneticist Francis Collins that explains how advances in genomics are transforming medicine and personal health.
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C.
Symbiosis in Cell Evolution
Symbiosis in Cell Evolution is a landmark scientific book by Lynn Margulis that argues complex eukaryotic cells arose through symbiotic mergers of simpler organisms, helping establish the endosymbiotic theory in evolutionary biology.
-
D.
Molecular Biology of the Gene
Molecular Biology of the Gene is a landmark molecular biology textbook, co-authored by James Watson, that helped define and systematize modern understanding of DNA structure, gene function, and genetic regulation.
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E.
Genetics of the Evolutionary Process
Genetics of the Evolutionary Process is a seminal work in evolutionary biology that synthesizes genetic principles with natural selection to explain how evolutionary change occurs within and between populations.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: A Genetic Switch: Phage Lambda and Higher Organisms Target entity description: "A Genetic Switch: Phage Lambda and Higher Organisms" is a seminal molecular biology book that explains how gene regulation in bacteriophage lambda illuminates fundamental mechanisms of genetic control in more complex organisms.
-
A.
From Bacteria to Bach and Back
From Bacteria to Bach and Back is a philosophical work by Daniel Dennett that explores how mind, consciousness, and culture could have evolved from simple biological beginnings through natural selection and cultural evolution.
-
B.
The Language of Life
The Language of Life is a popular science book by geneticist Francis Collins that explains how advances in genomics are transforming medicine and personal health.
-
C.
Symbiosis in Cell Evolution
Symbiosis in Cell Evolution is a landmark scientific book by Lynn Margulis that argues complex eukaryotic cells arose through symbiotic mergers of simpler organisms, helping establish the endosymbiotic theory in evolutionary biology.
-
D.
Molecular Biology of the Gene
Molecular Biology of the Gene is a landmark molecular biology textbook, co-authored by James Watson, that helped define and systematize modern understanding of DNA structure, gene function, and genetic regulation.
-
E.
Genetics of the Evolutionary Process
Genetics of the Evolutionary Process is a seminal work in evolutionary biology that synthesizes genetic principles with natural selection to explain how evolutionary change occurs within and between populations.
- F. None of above. chosen
Statements (45)
| Predicate | Object |
|---|---|
| instanceOf |
book
ⓘ
molecular biology book ⓘ scientific monograph ⓘ |
| aimsTo | connect phage lambda regulation to higher organism gene control ⓘ |
| author | Mark Ptashne ⓘ |
| discusses |
DNA regulatory sequences
ⓘ
allosteric regulation of regulatory proteins ⓘ epigenetic-like memory in phage lambda states ⓘ protein-DNA binding specificity ⓘ |
| educationalUse |
advanced undergraduate genetics courses
ⓘ
graduate-level molecular biology ⓘ |
| explains |
how phage lambda gene regulation works
ⓘ
how simple genetic circuits generate complex behaviors ⓘ molecular mechanisms of transcriptional control ⓘ principles of genetic control applicable to higher organisms ⓘ role of DNA-protein interactions in gene regulation ⓘ |
| field |
gene regulation
ⓘ
genetics ⓘ molecular biology ⓘ |
| focusesOn |
cooperative binding of regulatory proteins
ⓘ
feedback loops in gene regulation ⓘ lysogenic-lytic switch of phage lambda ⓘ operator sites in DNA ⓘ promoters and transcription initiation ⓘ regulatory proteins CI and Cro ⓘ |
| genre |
non-fiction
ⓘ
scientific literature ⓘ |
| hasReputation |
classic text in molecular biology
ⓘ
seminal work in gene regulation ⓘ |
| illustrates |
general principles of regulatory networks
ⓘ
use of bacteriophage lambda as a model system ⓘ |
| influencedField |
development of systems biology concepts
ⓘ
understanding of transcriptional regulation ⓘ |
| language | English ⓘ |
| mainSubject |
bacteriophage lambda
ⓘ
gene regulatory circuits ⓘ genetic switches ⓘ transcriptional regulation ⓘ |
| targetAudience |
biochemistry students
ⓘ
geneticists ⓘ molecular biologists ⓘ researchers interested in gene regulatory networks ⓘ |
| teaches | how quantitative models describe gene regulation ⓘ |
| title | A Genetic Switch: Phage Lambda and Higher Organisms ⓘ |
| usesModelOrganism |
Escherichia coli bacteriophage lambda
ⓘ
linked to:
bacteriophage lambda
|
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: A Genetic Switch: Phage Lambda and Higher Organisms Description of subject: "A Genetic Switch: Phage Lambda and Higher Organisms" is a seminal molecular biology book that explains how gene regulation in bacteriophage lambda illuminates fundamental mechanisms of genetic control in more complex organisms.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
A Genetic Switch: Phage Lambda and Higher Organisms
→
title
→
A Genetic Switch: Phage Lambda and Higher Organisms
ⓘ
linked to: A Genetic Switch: Phage Lambda and Higher Organisms