Mark Ptashne
E97006
Mark Ptashne is an American molecular biologist renowned for his pioneering work on gene regulation and the discovery of how transcription factors control gene expression in phage and eukaryotic systems.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Mark Ptashne canonical | 5 |
| Ptashne | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T778022 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Mark Ptashne Context triple: [James Watson, notableStudent, Mark Ptashne]
-
A.
Phillip A. Sharp
Phillip A. Sharp is an American molecular biologist and Nobel laureate renowned for his discovery of RNA splicing and his long-standing research and leadership at MIT.
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B.
J. Michael Bishop
J. Michael Bishop is an American immunologist and microbiologist who shared the 1989 Nobel Prize in Physiology or Medicine for discovering the cellular origin of retroviral oncogenes, fundamentally advancing cancer biology.
-
C.
Christiane Nüsslein-Volhard
Christiane Nüsslein-Volhard is a German developmental biologist and Nobel Prize laureate renowned for her pioneering work on the genetic control of embryonic development in Drosophila.
-
D.
Christopher Varmus
Christopher Varmus is one of the sons of Nobel Prize–winning American cancer researcher and former NIH director Harold Varmus.
-
E.
Walter Gilbert
Walter Gilbert is an American molecular biologist and Nobel laureate renowned for his pioneering work in DNA sequencing and gene regulation.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Mark Ptashne Target entity description: Mark Ptashne is an American molecular biologist renowned for his pioneering work on gene regulation and the discovery of how transcription factors control gene expression in phage and eukaryotic systems.
-
A.
Phillip A. Sharp
Phillip A. Sharp is an American molecular biologist and Nobel laureate renowned for his discovery of RNA splicing and his long-standing research and leadership at MIT.
-
B.
J. Michael Bishop
J. Michael Bishop is an American immunologist and microbiologist who shared the 1989 Nobel Prize in Physiology or Medicine for discovering the cellular origin of retroviral oncogenes, fundamentally advancing cancer biology.
-
C.
Christiane Nüsslein-Volhard
Christiane Nüsslein-Volhard is a German developmental biologist and Nobel Prize laureate renowned for her pioneering work on the genetic control of embryonic development in Drosophila.
-
D.
Christopher Varmus
Christopher Varmus is one of the sons of Nobel Prize–winning American cancer researcher and former NIH director Harold Varmus.
-
E.
Walter Gilbert
Walter Gilbert is an American molecular biologist and Nobel laureate renowned for his pioneering work in DNA sequencing and gene regulation.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
American scientist
ⓘ
geneticist ⓘ human ⓘ molecular biologist ⓘ |
| academicDegree | PhD in biology ⓘ |
| authorOf |
A Genetic Switch: Phage Lambda and Higher Organisms
ⓘ
Genes and Signals ⓘ |
| awardReceived |
Albert Lasker Award for Basic Medical Research
ⓘ
Genetics Society of America Medal ⓘ Louisa Gross Horwitz Prize ⓘ Massry Prize ⓘ |
| citizenship | United States of America ⓘ |
| educatedAt |
Harvard University
ⓘ
Reed College ⓘ |
| employer |
Harvard University
ⓘ
Memorial Sloan Kettering Cancer Center ⓘ |
| familyName |
Ptashne
ⓘ
linked to:
Mark Ptashne
|
| fieldOfWork |
biochemistry
ⓘ
gene regulation ⓘ molecular biology ⓘ transcriptional regulation ⓘ |
| givenName | Mark ⓘ |
| influenced |
development of molecular genetics of bacteriophages
ⓘ
modern understanding of transcriptional control ⓘ |
| knownFor |
conceptual advances in gene regulatory circuits
ⓘ
demonstrating specific DNA-binding proteins as gene regulators ⓘ discovery of how transcription factors control gene expression ⓘ pioneering work on gene regulation ⓘ research on the Cro protein of bacteriophage lambda ⓘ research on the lambda repressor ⓘ studies of gene regulation in bacteriophage lambda ⓘ studies of gene regulation in eukaryotic systems ⓘ work on transcription factors ⓘ |
| languageSpoken | English ⓘ |
| memberOf |
American Academy of Arts and Sciences
ⓘ
National Academy of Sciences of the United States of America ⓘ
linked to:
National Academy of Sciences
|
| name | Mark Ptashne ⓘ |
| nationality | United States of America ⓘ |
| notableWork | A Genetic Switch: Phage Lambda and Higher Organisms ⓘ |
| occupation |
molecular biologist
ⓘ
research scientist ⓘ university professor ⓘ |
| positionHeld |
Ludwig Chair of Molecular Biology at Memorial Sloan Kettering Cancer Center
ⓘ
professor at Harvard University ⓘ |
| researchFocus |
epigenetic regulation by transcription factors
ⓘ
protein–DNA interactions ⓘ transcription factors in eukaryotes ⓘ transcription factors in phage lambda ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Mark Ptashne Description of subject: Mark Ptashne is an American molecular biologist renowned for his pioneering work on gene regulation and the discovery of how transcription factors control gene expression in phage and eukaryotic systems.
Referenced by (6)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Mark Ptashne