Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc

E299919

set of transcription factors

Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc are a set of transcription factors whose forced expression can reprogram differentiated somatic cells into induced pluripotent stem cells.

Try in SPARQL Jump to: Surface forms Disambiguation Statements Elicitation Referenced by

All labels observed (3)

Label	Occurrences
Klf4	1
Oct3/4 maintains pluripotency	1
Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc canonical	1

How this entity was disambiguated

This entity first appeared as the object of triple T2800020 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc
Context triple: [Shinya Yamanaka, notableConcept, Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc]

A. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases
The Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases is a research consortium focused on understanding how cellular stress mechanisms contribute to aging and age-related diseases to develop new therapeutic strategies.
B. Center for Cellular and Molecular Therapeutics
The Center for Cellular and Molecular Therapeutics is a research institute specializing in developing gene and cell-based therapies for pediatric and genetic diseases.
C. Szostak Design
Szostak Design is an architectural firm known for designing prominent cultural and performing arts venues, including the Durham Performing Arts Center in North Carolina.
D. The Language of Life
The Language of Life is a popular science book by geneticist Francis Collins that explains how advances in genomics are transforming medicine and personal health.
E. The Cell
The Cell is a nickname for the Chicago White Sox’s home ballpark, officially known for much of its history as U.S. Cellular Field.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc
Target entity description: Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc are a set of transcription factors whose forced expression can reprogram differentiated somatic cells into induced pluripotent stem cells.

A. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases
The Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases is a research consortium focused on understanding how cellular stress mechanisms contribute to aging and age-related diseases to develop new therapeutic strategies.
B. Center for Cellular and Molecular Therapeutics
The Center for Cellular and Molecular Therapeutics is a research institute specializing in developing gene and cell-based therapies for pediatric and genetic diseases.
C. Szostak Design
Szostak Design is an architectural firm known for designing prominent cultural and performing arts venues, including the Durham Performing Arts Center in North Carolina.
D. The Language of Life
The Language of Life is a popular science book by geneticist Francis Collins that explains how advances in genomics are transforming medicine and personal health.
E. The Cell
The Cell is a nickname for the Chicago White Sox’s home ballpark, officially known for much of its history as U.S. Cellular Field.
F. None of above. chosen

Statements (46)

Predicate	Object
instanceOf	set of transcription factors ⓘ
alsoKnownAs	OSKM factors ⓘ Yamanaka factors ⓘ reprogramming factors ⓘ
associatedWith	embryonic stem cell–like gene expression program ⓘ induced pluripotent stem cells ⓘ
biologicalProcess	cellular reprogramming ⓘ epigenetic reprogramming ⓘ induction of pluripotency ⓘ
cellTypeReprogrammed	human fibroblasts ⓘ mouse fibroblasts ⓘ various somatic cell types ⓘ
componentRole	Klf4 regulates proliferation and self-renewal ⓘ Oct3/4 maintains pluripotency ⓘ linked to: Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc Sox2 maintains pluripotency ⓘ c-Myc promotes proliferation and chromatin remodeling ⓘ
deliveryMethod	Sendai virus vectors ⓘ episomal plasmids ⓘ lentiviral vectors ⓘ mRNA transfection ⓘ non-integrating vectors ⓘ protein transduction ⓘ retroviral vectors ⓘ
discoveredBy	Shinya Yamanaka ⓘ
discoveryYear	2006 ⓘ
function	reprogram differentiated somatic cells into induced pluripotent stem cells ⓘ
hasMember	Klf4 ⓘ linked to: Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc Oct3/4 ⓘ Sox2 ⓘ c-Myc ⓘ
induces	expression of pluripotency-associated genes ⓘ
molecularFunction	DNA-binding transcription factor activity ⓘ
organismContext	Homo sapiens ⓘ Mus musculus ⓘ linked to: house mouse (Mus musculus)
pathway	pluripotency network regulation ⓘ
relatedAward	Nobel Prize in Physiology or Medicine 2012 ⓘ linked to: Nobel Prize in Physiology or Medicine
relatedField	cellular reprogramming research ⓘ regenerative medicine ⓘ stem cell biology ⓘ
risk	genomic instability ⓘ tumorigenesis ⓘ
suppresses	differentiation-associated genes ⓘ
usedFor	disease modeling ⓘ drug screening ⓘ generation of induced pluripotent stem cells ⓘ regenerative medicine research ⓘ

How these facts were elicited

Referenced by (3)

Full triples — surface form annotated when it differs from this entity's canonical label.

Shinya Yamanaka → notableConcept → Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc ⓘ

Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc → hasMember → Klf4 ⓘ

linked to: Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc

Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc → componentRole → Oct3/4 maintains pluripotency ⓘ