Yamanaka factors
E299917
Yamanaka factors are a set of transcription factors that can reprogram adult somatic cells into induced pluripotent stem cells, revolutionizing regenerative medicine and stem cell research.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Yamanaka factors canonical | 2 |
| Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2799994 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Yamanaka factors Context triple: [Shinya Yamanaka, knownFor, Yamanaka factors]
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A.
DPPA
DPPA is the United Nations department responsible for conflict prevention, peacemaking, and supporting political and peacebuilding efforts worldwide.
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B.
Kashiwara
Kashiwara is a city in Osaka Prefecture, Japan, known as a suburban residential and commercial area within the Kansai region’s rail network.
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C.
Center for Cellular and Molecular Therapeutics
The Center for Cellular and Molecular Therapeutics is a research institute specializing in developing gene and cell-based therapies for pediatric and genetic diseases.
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D.
Cambridge Blood and Stem Cell Biobank
The Cambridge Blood and Stem Cell Biobank is a major research facility that collects, processes, and stores human blood and stem cell samples to support biomedical and translational research.
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E.
The Cell
The Cell is a nickname for the Chicago White Sox’s home ballpark, officially known for much of its history as U.S. Cellular Field.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Yamanaka factors Target entity description: Yamanaka factors are a set of transcription factors that can reprogram adult somatic cells into induced pluripotent stem cells, revolutionizing regenerative medicine and stem cell research.
-
A.
DPPA
DPPA is the United Nations department responsible for conflict prevention, peacemaking, and supporting political and peacebuilding efforts worldwide.
-
B.
Kashiwara
Kashiwara is a city in Osaka Prefecture, Japan, known as a suburban residential and commercial area within the Kansai region’s rail network.
-
C.
Center for Cellular and Molecular Therapeutics
The Center for Cellular and Molecular Therapeutics is a research institute specializing in developing gene and cell-based therapies for pediatric and genetic diseases.
-
D.
Cambridge Blood and Stem Cell Biobank
The Cambridge Blood and Stem Cell Biobank is a major research facility that collects, processes, and stores human blood and stem cell samples to support biomedical and translational research.
-
E.
The Cell
The Cell is a nickname for the Chicago White Sox’s home ballpark, officially known for much of its history as U.S. Cellular Field.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
cell reprogramming factors
ⓘ
set of transcription factors ⓘ |
| alternativeName |
OSKM factors
ⓘ
reprogramming factors ⓘ |
| associatedWithAward |
2012 Nobel Prize in Physiology or Medicine
ⓘ
linked to:
Nobel Prize in Physiology or Medicine
|
| associatedWithField |
developmental biology
ⓘ
epigenetics ⓘ regenerative medicine ⓘ stem cell biology ⓘ |
| biologicalProcess |
cellular reprogramming
ⓘ
maintenance of pluripotency ⓘ regulation of transcription ⓘ |
| componentRole_c-Myc | enhancer of reprogramming efficiency ⓘ |
| componentRole_Klf4 | regulator of proliferation and self-renewal ⓘ |
| componentRole_Oct4 | core pluripotency regulator ⓘ |
| componentRole_Sox2 | pluripotency-associated transcription factor ⓘ |
| deliveryMethod |
episomal plasmids
ⓘ
mRNA transfection ⓘ non-integrating vectors ⓘ protein transduction ⓘ viral vectors ⓘ |
| discoveredBy | Shinya Yamanaka ⓘ |
| discoveryYear | 2006 ⓘ |
| effectOnCell | convert differentiated cells to pluripotent state ⓘ |
| effectOnGeneExpression |
activate pluripotency-associated genes
ⓘ
repress differentiation-associated genes ⓘ |
| firstDescribedIn | mouse fibroblasts ⓘ |
| firstPublicationTitle |
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
ⓘ
linked to:
Yamanaka factors
|
| firstPublicationYear | 2006 ⓘ |
| firstPublishedIn | Cell ⓘ |
| function |
induce pluripotency
ⓘ
reprogram adult somatic cells into induced pluripotent stem cells ⓘ reset epigenetic state of somatic cells ⓘ |
| hasMember |
Klf4
ⓘ
Oct4 ⓘ Sox2 ⓘ c-Myc ⓘ |
| impact |
enabled patient-specific pluripotent stem cells without embryos
ⓘ
revolutionized induced pluripotent stem cell technology ⓘ |
| laterAppliedTo | human somatic cells ⓘ |
| molecularFunction | DNA-binding transcription factor activity ⓘ |
| namedAfter | Shinya Yamanaka ⓘ |
| risk | c-Myc component is oncogenic ⓘ |
| speciesOriginallyTestedIn |
Mus musculus
ⓘ
linked to:
house mouse (Mus musculus)
|
| usedIn |
cell-based therapies research
ⓘ
disease modeling ⓘ drug screening ⓘ generation of induced pluripotent stem cells ⓘ regenerative medicine research ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Yamanaka factors Description of subject: Yamanaka factors are a set of transcription factors that can reprogram adult somatic cells into induced pluripotent stem cells, revolutionizing regenerative medicine and stem cell research.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
Yamanaka factors
→
firstPublicationTitle
→
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
ⓘ
linked to: Yamanaka factors